A Randomized Trial of Generic Versus Tailored Interventions to Increase Colorectal Cancer Screening Among Intermediate Risk Siblings

  • Sharon L. Manne
  • Elliot J. Coups
  • Arnold Markowitz
  • Neal J. Meropol
  • Daniel Haller
  • Paul B. Jacobsen
  • Lina Jandorf
  • Susan K. Peterson
  • Samuel Lesko
  • Steven Pilipshen
  • Gary Winkel
Original Article



Individuals with a sibling who has had colorectal cancer diagnosed before age 61 are at increased risk for colorectal cancer and may derive particular benefit from screening. Tailored interventions may increase participation in appropriate colorectal cancer screening.


This study evaluated the efficacy of two tailored interventions and a generic print intervention.


Participant siblings (N = 412) who were not up-to-date with colorectal cancer screening were randomly assigned to receive either a generic print pamphlet, a tailored print pamphlet, or a tailored print pamphlet and tailored counseling call. Colorectal cancer screening 6 months after the baseline interview was the outcome measure.


Results indicated that colorectal cancer screening adherence increased among intermediate risk siblings enrolled in all three intervention groups. Participants in both tailored intervention groups reported having colorectal cancer screening at significantly higher rates than participants in the generic print group. The increase in colorectal cancer screening in the tailored print and counseling call group was not significantly higher than that achieved by the tailored print alone. Decisional balance partially mediated treatment effects. Tailored behavioral interventions are effective methods for increasing screening adherence but telephone counseling did not add significantly to treatment effects.


Colorectal cancer screening Tailored interventions Intermediate risk siblings 


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Copyright information

© The Society of Behavioral Medicine 2009

Authors and Affiliations

  • Sharon L. Manne
    • 1
  • Elliot J. Coups
    • 1
  • Arnold Markowitz
    • 2
  • Neal J. Meropol
    • 1
  • Daniel Haller
    • 3
  • Paul B. Jacobsen
    • 4
  • Lina Jandorf
    • 5
  • Susan K. Peterson
    • 6
  • Samuel Lesko
    • 7
  • Steven Pilipshen
    • 8
  • Gary Winkel
    • 9
  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.The Hospital of the University of PennsylvaniaPhiladelphiaUSA
  4. 4.Moffitt Cancer CenterTampaUSA
  5. 5.Mount Sinai School of MedicineNew YorkUSA
  6. 6.The University of Texas M.D. Anderson Cancer CenterHoustonUSA
  7. 7.Northeast Regional Cancer InstituteScrantonUSA
  8. 8.Colorectal Surgical Associates of New JerseyShrewsburyUSA
  9. 9.City University of New YorkNew YorkUSA

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