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Helicobacter pylori au Burundi : première évaluation de la prévalence en endoscopie et de l’éradication

Helicobacter pylori in Burundi: first assessment of prevalence in endoscopy and eradication

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Journal Africain d'Hépato-Gastroentérologie

Résumé

But

L’éradication de l’Helicobacter pylori (H. pylori) aboutit à la cicatrisation des lésions gastroduodénales et permet d’éviter l’évolution vers l’adénocarcinome gastrique et le lymphome du MALT. Le but de l’étude était d’évaluer la prévalence de H. pylori chez les personnes fréquentant les structures de soins et l’efficacité des antibiotiques disponibles dans notre pays pour son éradication.

Méthodes

Étude prospective randomisée ayant inclus des patients qui ont subit une endoscopie digestive haute avec recherche de H. pylori. Son diagnostic et le contrôle de son éradication ont été faits sur des biopsies gastriques par un test direct à l’uréase, le He-Py Test Gold®.

Résultats

Au total 257 patients ont été inclus. La prévalence de H. pylori était estimée à 70,8%. Le taux d’éradication de H. pylori était de 18,7% par l’association Oméprazole 20 mg + Métronidazole 500 mg + Amoxicilline 1000 mg (OMA) toutes les 12 heures pendant une durée de 7 jours. Il était de 59,3% par le même schéma OMA pendant 10 jours et de 84,6% par le schéma Oméprazole 20 mg + Clarithromycine 500 mg + Amoxicilline 1000 mg (OCA) toutes les 12 heures pendant une durée de 10 jours.

Conclusion

La prévalence de H. pylori est élevée dans notre pays. Le taux de son éradication avec le métronidazole est très bas. Un usage réglementé de la clarithromycine devait être instauré pour préserver son efficacité qui est encore élevée.

Abstract

Aim

The Helicobacter pylori (H. pylori) eradication induces the healing of gastroduodenal lesions and avoids the evolution into a gastric adenocarcinoma or into a mucosa-associated lymphoid tissue (MALT) lymphoma. The aim of the study was to determine the prevalence of H. pylori among patients attending medical cares and the efficiency of antibiotics accessible in our country for its eradication.

Methods

This is a randomized prospective study which included patients who underwent upper endoscopy with a research of H. pylori. The diagnosis and the assessment of H. pylori eradication have been made on gastric biopsies by a rapid urease test, the He-Py Test Gold®.

Results

A total of 257 patients have been included. The prevalence of H. pylori was estimated to 70,8%. The rate of H. pylori eradication was 18,7% by the regimen of Omeprazole 20 mg + Metronidazole 500 mg + Amoxicilline 1000 mg (OMA) twice a day during 7 days. It was 59,3% by the OMA 10 days and 84,6% by the regimen of Omeprazole 20 mg + Clarithromycine 500 mg + Amoxicillin 1000 mg (OCA) twice a day during 10 days.

Conclusion

The prevalence of H. pylori is high in our country. The rate of its eradication with the metronidazole is very low. A coordinated use of clarithromycine should be initiated in our country to protect its efficiency, which seems to be high.

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Authors and Affiliations

  1. Centre hospitalo-universitaire de Kamenge, Bujumbura, Burundi

    R. Ntagirabiri, S. Harerimana, F. Makuraza, E. Ndirahisha, H. Kaze & A. Moibeni

  2. Centre des maladies du tube digestif et du foie « CEMADIF », Bujumbura, Burundi

    R. Ntagirabiri & H. Kaze

Authors
  1. R. Ntagirabiri
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  2. S. Harerimana
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  3. F. Makuraza
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  4. E. Ndirahisha
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  5. H. Kaze
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  6. A. Moibeni
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Corresponding author

Correspondence to R. Ntagirabiri.

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Ntagirabiri, R., Harerimana, S., Makuraza, F. et al. Helicobacter pylori au Burundi : première évaluation de la prévalence en endoscopie et de l’éradication. J Afr Hepato Gastroenterol 8, 217–222 (2014). https://doi.org/10.1007/s12157-014-0567-3

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  • DOI: https://doi.org/10.1007/s12157-014-0567-3

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