Oncology Reviews

, Volume 1, Issue 4, pp 225–232 | Cite as

Role of CD1A and HSP60 in the antitumoral response of oesophageal cancer

  • Simona Corrao
  • Giampiero La Rocca
  • Rita Anzalone
  • Lorenzo Marasà
  • Felicia Farina
  • Giovanni Zummo
  • Francesco CappelloEmail author


Oesophageal cancer (OC) is one of the most common and severe forms of tumor. A wider knowledge of molecular mechanisms which lead to a normal epithelium becoming a neoplasm may reveal new strategies to improve treatment and outcome of this disease.

In this review, we report recent findings concerning molecular events which take place during carcinogenesis of the oesophagus. In particular, we focus on the role of two molecules, CD1a and Hsp60, which are overexpressed in oesophageal and many other types of tumor. Both molecules may present tumor antigens and promote in situ the stimulation of an antitumoral immune activity. We suggest there is a synergistic action between these molecules. Further knowledge about their intracellular pathways and extracellular roles may help develop new antitumoral tools for OC.

Key words

Immune response Dendritic cells Chaperonopathies Chaperonotherapy 


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Copyright information

© Springer 2008

Authors and Affiliations

  • Simona Corrao
    • 1
  • Giampiero La Rocca
    • 1
  • Rita Anzalone
    • 1
  • Lorenzo Marasà
    • 1
  • Felicia Farina
    • 1
  • Giovanni Zummo
    • 1
  • Francesco Cappello
    • 1
    Email author
  1. 1.Dipartimento di Medicina Sperimentale, Sezione di Anatomia UmanaUniversità di PalermoPalermoItaly

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