Oncology Reviews

, Volume 1, Issue 1, pp 53–64 | Cite as

Advances in diffuse malignant peritoneal mesothelioma

  • Tristan D. Yan
  • Raffit Hassan
  • Laura Welch
  • Paul H. Sugarbaker


Malignant mesothelioma is a highly aggressive neoplasm. The incidence of malignant mesothelioma is increasing worldwide. Diffuse malignant peritoneal mesothelioma (DMPM) represents one-fourth of all mesotheliomas. Association of asbestos exposure with DMPM has been observed, especially in males. A great majority of patients present with abdominal pain and distension, caused by accumulation of tumors and ascitic fluid. In the past, DMPM was considered a pre-terminal condition; therefore attracted little attention. Patients invariably died from their disease within a year. Recently, several prospective trials have demonstrated median survival of 40 to 90 months and 5-year survival of 30% to 60% after the combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy. This improvement in survival has prompted new searches into the medical science related to DMPM, a disease previously ignored as uninteresting. This review article focuses on the key advances in the epidemiology, diagnosis, staging, treatments and prognosis of DMPM that have occurred in the past decade.

Key words

Peritoneal mesothelioma Asbestos Cytoreductive surgery Peritonectomy Intraperitoneal chemotherapy Mesothelin Doxorubicin Cisplatin Pemetrexed 


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Copyright information

© Springer 2007

Authors and Affiliations

  • Tristan D. Yan
    • 1
  • Raffit Hassan
    • 2
  • Laura Welch
    • 3
  • Paul H. Sugarbaker
    • 1
  1. 1.Peritoneal Surface Malignancy Program, Washington Cancer InstituteWashington Hospital CenterWashington, DCUSA
  2. 2.Laboratory of Molecular Biology, Center for Cancer Research, National Cancer InstituteNational Institute of HealthBethesdaUSA
  3. 3.Center to Protect Worker’s RightsSilver SpringUSA

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