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Feasibility of whole-body 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography angiography using continuous bed motion in patients with vascular disease: a pilot study

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Abstract

Objective

Positron emission tomography (PET) angiography is a promising PET imaging method for vessel evaluation. With advances in PET technologies, PET angiography of the whole body is now possible using continuous bed motion (CBM) mode. This study aimed to evaluate the image quality for depicting the aorta and main branches and the diagnostic performance of whole-body PET angiography in patients with vascular disease.

Methods

We retrospectively identified 12 consecutive patients who underwent whole-body 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET angiography in CBM mode. Whole-body PET angiography was performed between 20 and 45 s after administering [18F]FDG using CBM from the neck to the pelvis. The visibility of whole-body PET angiography was assessed for the 24 segments in three regions per patient using a 4-point grading scale (1, unacceptable; 2, poor; 3, good; 4, excellent), and grades 3 and 4 were considered diagnostic. The diagnostic accuracy of whole-body PET angiography for detecting vascular abnormalities was calculated using contrast-enhanced CT as a reference standard.

Results

We evaluated 285 segments from 12 patients, and overall, 170/285 segments (60%) were considered diagnostic throughout the whole body, including 96/117 (82%), 22/72 (31%), and 52/96 (54%) segments in the neck-to-chest region, abdominal region, and pelvic region, respectively. The sensitivity, specificity, and accuracy of whole-body PET angiography for detecting vascular abnormalities were 75.9%, 98.8%, and 96.5%, respectively.

Conclusions

Whole-body PET angiography showed a better image quality for the neck-to-chest and pelvic regions in this setting, although it provided limited information on the vessels in the abdominal region.

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Abbreviations

3D:

Three-dimensional

CBM:

Continuous bed motion

CTA:

Computed tomography angiography

[18F]FDG:

2-Deoxy-2-[18F]fluoro-d-glucose

[18F]FEC:

[18F]fluoroethylcholine

GCA:

Giant cell arteritis

MRA:

Magnetic resonance angiography

PET:

Positron emission tomography

RNA:

Radionuclide angiography

TAK:

Takayasu arteritis

References

  1. Miyamae T, Fujioka M, Tsubogo Y, Tonariya Y, Dohi Y, Akashi Y, et al. Detection of a large arteriovenous fistula between the internal Iliac vessels by radionuclide angiography. J Nucl Med. 1979;20:36–8.

    CAS  PubMed  Google Scholar 

  2. Garty I, Siplovich L, Horowitz J, Miron D, Verstandig A, Dharan M. Radionuclide blood pool scintigraphy in a child with intestinal arteriovenous malformation (juvenile angiodysplasia). A case report and review of the literature. Eur J Nucl Med. 1991;18:992–5. https://doi.org/10.1007/BF00180422.

    Article  CAS  PubMed  Google Scholar 

  3. Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K. Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology. 1990;175:621–8. https://doi.org/10.1148/radiology.175.3.2343107.

    Article  CAS  PubMed  Google Scholar 

  4. van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, et al. Post-contrast acute kidney injury—part 1: definition, clinical features, incidence, role of contrast medium and risk factors: recommendations for updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol. 2018;28:2845–55. https://doi.org/10.1007/s00330-017-5246-5.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bernstine H, Braun M, Yefremov N, Lamash Y, Carmi R, Stern D, et al. FDG PET/CT early dynamic blood flow and late standardized uptake value determination in hepatocellular carcinoma. Radiology. 2011;260:503–10. https://doi.org/10.1148/radiol.11102350.

    Article  PubMed  Google Scholar 

  6. Schierz JH, Opfermann T, Steenbeck J, Lopatta E, Settmacher U, Stallmach A, et al. Early dynamic 18F-FDG PET to detect hyperperfusion in hepatocellular carcinoma liver lesions. J Nucl Med. 2013;54:848–54. https://doi.org/10.2967/jnumed.112.113936.

    Article  CAS  PubMed  Google Scholar 

  7. Drescher R, Freesmeyer M. PET angiography: application of early dynamic PET/CT to the evaluation of arteries. AJR Am J Roentgenol. 2013;201:908–11. https://doi.org/10.2214/AJR.12.10438.

    Article  PubMed  Google Scholar 

  8. Drescher R, Freesmeyer M. F-18 fluorodeoxyglucose PET angiography of the abdominal arteries: evaluation of image quality and comparison with contrast-enhanced CT. Ann Nucl Med. 2015;29:198–205. https://doi.org/10.1007/s12149-014-0930-x.

    Article  CAS  PubMed  Google Scholar 

  9. Freesmeyer M, Drescher R. F-18 choline PET angiography of the pelvic arteries: evaluation of image quality and comparison with contrast-enhanced CT. Clin Imaging. 2015;39:437–41. https://doi.org/10.1016/j.clinimag.2014.08.007.

    Article  PubMed  Google Scholar 

  10. Shiga T, Morimoto Y, Kubo N, Katoh N, Katoh C, Takeuchi W, et al. A new PET scanner with semiconductor detectors enables better identification of intratumoral inhomogeneity. J Nucl Med. 2009;50:148–55. https://doi.org/10.2967/jnumed.108.054833.

    Article  PubMed  Google Scholar 

  11. Osborne DR, Acuff S, Cruise S, Syed M, Neveu M, Stuckey A, et al. Quantitative and qualitative comparison of continuous bed motion and traditional step and shoot PET/CT. Am J Nucl Med Mol Imaging. 2015;5:56–64.

    PubMed  Google Scholar 

  12. Schatka I, Weiberg D, Reichelt S, Owsianski-Hille N, Derlin T, Berding G, et al. A randomized, double-blind, crossover comparison of novel continuous bed motion versus traditional bed position whole-body PET/CT imaging. Eur J Nucl Med Mol Imaging. 2016;43:711–7. https://doi.org/10.1007/s00259-015-3226-z.

    Article  PubMed  Google Scholar 

  13. Norikane T, Yamamoto Y, Takami Y, Mitamura K, Matsumoto K, Maeda Y, et al. Whole-body PET angiography on semiconductor PET/CT. J Nucl Cardiol. 2022;29:885–8. https://doi.org/10.1007/s12350-021-02708-5.

    Article  PubMed  Google Scholar 

  14. Norikane T, Yamamoto Y, Arai-Okuda H, Dobashi H, Nishiyama Y. Pulmonary vasculitis on dual-phase 18F-FDG PET/CT in SAPHO syndrome. Clin Nucl Med. 2022;47:e411–3. https://doi.org/10.1097/RLU.0000000000004104.

    Article  PubMed  Google Scholar 

  15. Norikane T, Yamamoto Y, Takami Y, Mitamura K, Matsumoto K, Maeda Y, et al. Combination of whole body [18F]FDG PET angiography and PET/CT for giant cell arteritis. Eur J Nucl Med Mol Imaging. 2022;49:779–80. https://doi.org/10.1007/s00259-021-05532-8.

    Article  PubMed  Google Scholar 

  16. Viera AJ, Garrett JM. Understanding interobserver agreement: the kappa statistic. Fam Med. 2005;37:360–3.

    PubMed  Google Scholar 

  17. Awai K, Hatcho A, Nakayama Y, Kusunoki S, Liu D, Hatemura M, et al. Simulation of aortic peak enhancement on MDCT using a contrast material flow phantom: feasibility study. AJR Am J Roentgenol. 2006;186:379–85. https://doi.org/10.2214/AJR.04.1591.

    Article  PubMed  Google Scholar 

  18. Lee CH, Goo JM, Lee HJ, Kim KG, Im JG, Bae KT, et al. Determination of optimal timing window for pulmonary artery MDCT angiography. AJR Am J Roentgenol. 2007;188:313–7. https://doi.org/10.2214/AJR.06.0078.

    Article  PubMed  Google Scholar 

  19. Freesmeyer M, Drescher R, Roth J, Gühne F, Seifert P. Bilateral pulmonary thromboembolism detected by PET angiography in a patient with contraindications for contrast agent imaging. Heart Lung Circ. 2019;28:e96–8. https://doi.org/10.1016/j.hlc.2018.11.011.

    Article  PubMed  Google Scholar 

  20. Norikane T, Yamamoto Y, Takami Y, Mitamura K, Arai-Okuda H, Nishiyama Y. One-stop shopping 18F-FDG PET/CT in a patient with vascular type Behçet’s disease. Eur J Nucl Med Mol Imaging. 2019;46:1578–80. https://doi.org/10.1007/s00259-019-04293-9.

    Article  PubMed  Google Scholar 

  21. Frood R, McDermott G, Scarsbrook A. Respiratory-gated PET/CT for pulmonary lesion characterisation-promises and problems. Br J Radiol. 2018;91:20170640. https://doi.org/10.1259/bjr.20170640.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Lee JH, Ryu CW, Kim SM, Kim EJ, Choi WS. Usefulness of biphasic contrast injection in multidetector CT of the head and neck: a comparison with monophasic contrast injection. J Korean Soc Radiol. 2012;67:85–92. https://doi.org/10.3348/jksr.2012.67.2.85.

    Article  Google Scholar 

  23. Hsieh CC, Zeng AB, Chen CH, Jhou ZY, Wang CH, Yang YL, et al. A practical biphasic contrast media injection protocol strongly enhances the aorta and pulmonary artery simultaneously using a single CT angiography scan. BMC Med Imaging. 2021;21:160. https://doi.org/10.1186/s12880-021-00691-4.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Hayashida T, Sueyoshi E, Sakamoto I, Uetani M, Chiba K. PET features of aortic diseases. AJR Am J Roentgenol. 2010;195:229–33. https://doi.org/10.2214/AJR.09.3952.

    Article  PubMed  Google Scholar 

  25. Soussan M, Nicolas P, Schramm C, Katsahian S, Pop G, Fain O, et al. Management of large-vessel vasculitis with FDG-PET: a systematic literature review and meta-analysis. Medicine. 2015;94:e622. https://doi.org/10.1097/MD.0000000000000622.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Rosenbaum D, Millon A, Fayad ZA. Molecular imaging in atherosclerosis: FDG PET. Curr Atheroscler Rep. 2012;14:429–37. https://doi.org/10.1007/s11883-012-0264-x.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Moragas Solanes M, Andreu Magarolas M, Martín Miramon JC, Caresia Aróztegui AP, Monteagudo Jiménez M, Oliva Morera JC, et al. Comparative study of 18F-FDG PET/CT and CT angiography in detection of large vessel vasculitis. Rev Esp Med Nucl Imagen Mol. 2019;38:280–9. https://doi.org/10.1016/j.remn.2019.03.002.

    Article  CAS  PubMed  Google Scholar 

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Funding

This research was partially supported by the emerging research fund of the Kagawa University Research Promotion Program 2021 and 2022 (22K0C006).

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-Cho, Kita-Gun, Kagawa, 761-0793, Japan

    Takashi Norikane, Yuka Yamamoto, Yasukage Takami, Mitsumasa Murao, Yuri Manabe, Masashi Imajo & Yoshihiro Nishiyama

  2. Department of Clinical Radiology, Kagawa University Hospital, Kita-Gun, Kagawa, Japan

    Akihiro Oishi & Yukito Maeda

  3. Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-Gun, Kagawa, Japan

    Hiroaki Dobashi

Authors
  1. Takashi Norikane
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  2. Yuka Yamamoto
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  3. Yasukage Takami
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  4. Mitsumasa Murao
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Correspondence to Takashi Norikane.

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All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Norikane, T., Yamamoto, Y., Takami, Y. et al. Feasibility of whole-body 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography angiography using continuous bed motion in patients with vascular disease: a pilot study. Ann Nucl Med 37, 381–389 (2023). https://doi.org/10.1007/s12149-023-01835-y

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