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Brown tumors in nuclear medicine: a systematic review

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Abstract

Brown tumors (BT) are abnormal bone-repair processes and a consequence of hyperparathyroidism. The diagnosis of these lytic lesions in nuclear medicine, while a challenge, is not so rare, because functional imaging is used both in the management of cancer and hyperparathyroidism. The main objective of this review is to summarize the knowledge and the evidence concerning BT and the different imaging modalities in nuclear medicine. A systematic review was performed in Embase, PubMed and Google Scholar from 2005 to 2022. We included articles describing BT in the following imaging modalities: [18F]-fluorodeoxyglucose PET/CT, [18F]-fluorocholine or [11C]-fluorocholine PET/CT, [99mTc]-Sestamibi scintigraphy, bone scan, [18F]-sodium fluoride PET/CT, [68Ga]-FAPI PET/CT; [68Ga]-DOTATATE PET/CT; [11C]-methionine PET/CT. For each modality, appearance, avidity for radiotracer, available quantitative parameters and imaging evolution after parathyroidectomy were collected and analyzed. Fifty-two articles were included for a total of 392 BT lesions. If the diagnosis of BT is evoked on a known lesion, performing a [18F]-fluorocholine PET/CT imaging seems the most appropriate. In [18F]-fluorodeoxyglucose, [18F]-fluorocholine, [18F]-sodium fluoride PET/CT and bone scan, BT can mimic metastatic disease. BT uptakes appear reversible after parathyroidectomy, with a more or less rapid decrease depending on the imaging modality used.

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Data Availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Fraser WD. Hyperparathyroidism. Lancet. 2009;374:145–58. https://doi.org/10.1016/S0140-6736(09)60507-9.

    Article  CAS  PubMed  Google Scholar 

  2. Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism. Lancet. 2018;391:168–78. https://doi.org/10.1016/S0140-6736(17)31430-7.

    Article  CAS  PubMed  Google Scholar 

  3. Bilezikian JP, Silverberg SJ, Shane E, Parisien M, Dempster DW. Characterization and evaluation of asymptomatic primary hyperparathyroidism. J Bone Miner Res. 1991. https://doi.org/10.1002/jbmr.5650061419.

    Article  PubMed  Google Scholar 

  4. Choi JH, Kim KJ, Lee YJ, Kim SH, Kim SG, Jung KY, et al. Primary hyperparathyroidism with extensive brown tumors and multiple fractures in a 20-year-old woman. Endocrinol Metab. 2015;30:614–9. https://doi.org/10.3803/EnM.2015.30.4.614.

    Article  CAS  Google Scholar 

  5. Jafari-Pozve N, Ataie-Khorasgani M, Jafari-Pozve S, Ataie-Khorasgani M. Maxillofacial brown tumors in secondary hyperparathyroidism: a case report and literature review. J Res Med Sci. 2014;19:1099–1102.

    PubMed  PubMed Central  Google Scholar 

  6. Salaün PY, Abgral R, Malard O, Querellou-Lefranc S, Quere G, Wartski M, et al. Good clinical practice recommendations for the use of PET/CT in oncology. Eur J Nucl Med Mol Imaging. 2020;47:28–50. https://doi.org/10.1007/s00259-019-04553-8.

    Article  PubMed  Google Scholar 

  7. Treglia G, Piccardo A, Imperiale A, Strobel K, Kaufmann PA, Prior JO, et al. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2019;46:751–65. https://doi.org/10.1007/s00259-018-4123-z.

    Article  CAS  PubMed  Google Scholar 

  8. Petranović Ovčariček P, Giovanella L, Carrió Gasset I, Hindié E, Huellner MW, Luster M, et al. The EANM practice guidelines for parathyroid imaging. Eur J Nucl Med Mol Imaging. 2021;48:2801–22. https://doi.org/10.1007/s00259-021-05334-y.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2020. https://doi.org/10.1136/bmj.n71.

    Article  PubMed  Google Scholar 

  10. Fuat Yapar A, Aydin M, Reyhan M, Bal N, Yapar Z, Altun Yologlu N. Simultaneous visualization of a mandibular brown tumor with a large parathyroid adenoma on Tc-99m MIBI imaging. Clin Nucl Med. 2005;30:433–5.

    Article  PubMed  Google Scholar 

  11. Van Baardwijk A, De Jong J, Arens A, Thimister P, Verseput G, Kremer B, et al. False-positive FDG-PET scan due to brown tumours. Eur J Nucl Med Mol Imaging. 2006;33:393–4. https://doi.org/10.1007/s00259-005-1979-5.

    Article  PubMed  Google Scholar 

  12. Al-Makhzomi M, Sathekge M, Seynaeve MP, Nicolaij D, Maes A. PET/CT-positive brown tumour-a potentially misleading finding in the evaluation of a patient for malignant primary tumour or metastases. SA J Radiol. 2007;11:103–4.

    Article  Google Scholar 

  13. Diamanti-Kandarakis E, Livadas S, Tseleni-Balafouta S, Lyberopoulos K, Tantalaki E, Palioura H, et al. Brown tumor of the fibula: unusual presentation of an uncommon manifestation. Report of a case and review of the literature. Endocrine. 2007;32:345–9. https://doi.org/10.1007/s12020-008-9035-4.

    Article  CAS  PubMed  Google Scholar 

  14. Kemps B, Quarles Van Ufford H, Creyghton W, De Haas M, Baarslag HJ, Borel Rinkes I, et al. Brown tumors simulating metastases on FDG PET in a patient with parathyroid carcinoma. Eur J Nucl Med Mol Imaging. 2008;35:850. https://doi.org/10.1007/s00259-007-0712-y.

    Article  PubMed  Google Scholar 

  15. Hermoye A, Malghem J, Lecouvet F, Goffin E, Lonneux M, Lhommel R. F-18 FDG PET/CT as a noninvasive diagnostic and follow-up tool in brown tumors due to secondary hyperparathyroidism. Clin Nucl Med. 2009;34:330–2.

    Article  PubMed  Google Scholar 

  16. Ruggeri RM, Calamoneri E, Russo A, Sindoni A, Mondello B, Monaco M, et al. Supra-acetabular brown tumor due to primary hyperparathyroidism associated with chronic renal failure. Sci World J. 2010;10:799–805. https://doi.org/10.1100/tsw.2010.86.

    Article  Google Scholar 

  17. Meng Z, He Q, Shi T, Tian W, Xu W, Tan J. A hidden parathyroid adenoma behind a thyroid autonomous nodule causing multiple brown tumors advantages of tomography imaging over planar imaging. Clin Nucl Med. 2012;37:775–7.

    Article  PubMed  Google Scholar 

  18. Sager S, Halac M, Aliyev A, Oztürk T. Positron emission tomography/computed tomography imaging of brown tumors mimicking multiple skeletal metastases in patient with primary hyperparathyroidism. Indian J Endocrinol Metab. 2012;16:850. https://doi.org/10.4103/2230-8210.100682.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Bernal P, Ucros G, Mejia A. Mediastinal parathyroid adenoma and brown tumors. World J Nucl Med. 2012;11:39. https://doi.org/10.4103/1450-1147.98748.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Nagaraj C, Oommen R, Jacob PM, Irodi A. Solitary phalangeal brown tumour in primary hyperparathyroidism: report of a rare presentation. Indian J Nucl Med. 2012;27:107–10. https://doi.org/10.4103/0972-3919.110700.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Teodorczyk J, Cytawa W, Brockhuis B, Lass P. Case report advanced, lately diagnosed primary hyperparathyroidism in a patient mistakenly treated for multiple bone metastasis. A case report and review of the literature. Adv Palliat Med. 2012;11:77–82.

    Google Scholar 

  22. Heimburger C, Andres E, Rust E, Ghiura C, Dakayi Nono C, Hassler S, et al. Morpho-functional imaging in a patient with hyperparathyroidism and multifocal maxillary brown tumor. Rev Med Internet. 2013;34:377–81. https://doi.org/10.1016/j.revmed.2013.02.007.

    Article  CAS  Google Scholar 

  23. Asa S, Yilmaz S, Kaya R, Saǧer S, Halac M, Kabasakal L. Imaging of multiple brown tumors both in FDG (18F) and 68Ga DOTA-TATE PET/CT studies. Rev Esp Med Nucl Imagen Mol. 2013;32:404–5. https://doi.org/10.1016/j.remn.2013.05.004.

    Article  CAS  PubMed  Google Scholar 

  24. Rauch M, Perez-Bouza A, Strunk H. Brown tumors: a pitfall in PET-CT diagnosis. RoFo Fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgeb Verfahren. 2013;185:770–1. https://doi.org/10.1055/s-0033-1335515.

    Article  CAS  Google Scholar 

  25. Uslu L, Arzu C, Sait S, Teksöz S, Halaç M. Preoperative and postoperative 18 FDG PET/CT and bone scintigraphy images in a patient with parathyroid adenoma. Clin Nucl Med. 2013;38:456–8.

    Article  PubMed  Google Scholar 

  26. Zhang J, Wang H, Tian W, He Q, Zhu M. Brown tumor of the rib as a first presentation of primary hyperparathyroidism: report of three cases and literature review. Thorac Cancer. 2013;4:474–8. https://doi.org/10.1111/1759-7714.12045.

    Article  PubMed  Google Scholar 

  27. Guy MS, Jacob C, Mcdonald SD, Dowdy YG, Kardan A. 18F-FDG PET/CT metabolic variability in functioning oncocytic parathyroid adenoma with brown tumors. Clin Nucl Med. 2014;39:393–5.

    Article  PubMed  Google Scholar 

  28. Kerstens MN, De Vries R, Plukker JTM, Slart RHJA, Dullaart RPF. Multiple skeletal lesions on FDG PET in severe primary hyperparathyroidism. Eur J Nucl Med Mol Imaging. 2014;41:182–3. https://doi.org/10.1007/s00259-013-2509-5.

    Article  CAS  PubMed  Google Scholar 

  29. Wang X, Wang M, Zhang J, Zhu Y, Zhu M, Gao H, et al. Humeral brown tumor as first presentation of primary hyperparathyroidism caused by ectopic parathyroid adenomas: report of two cases and review of literature. Int J Clin Exp Pathol. 2014;7:7094–9.

    PubMed  PubMed Central  Google Scholar 

  30. Kara Gedik G, Yavas O, Karabagli P. Differential diagnosis between secondary and tertiary hyperparathyroidism in a case of a giant-cell and brown tumor containing mass. Findings by 99mTc-MDP, 18F-FDG PET/CT and 99mTc-MIBI scans. Artic Hell J Nucl Med. 2014;17:214–7. https://doi.org/10.1967/s002449910147.

    Article  Google Scholar 

  31. Andersen KF, Albrecht-Beste E. Brown tumors due to primary hyperparathyroidism in a patient with parathyroid carcinoma mimicking skeletal metastases on 18F-FDG PET/CT. Diagnostics. 2015;5:290–3. https://doi.org/10.3390/diagnostics5030290.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Win AZ, Aparici CM. NaF18-PET/CT imaging of secondary hyperparathyroidism. Nucl Med Mol Imaging. 2010;2015(49):331–2. https://doi.org/10.1007/s13139-015-0319-3.

    Article  Google Scholar 

  33. Raubenheimer EJ, Noffke CE, Mohamed A. Expansive jaw lesions in chronic kidney disease: review of the literature and a report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:340–5. https://doi.org/10.1016/j.oooo.2014.11.002.

    Article  PubMed  Google Scholar 

  34. Phulsunga R, Parghane R, Kanojia R, Gochhait D, Sood A, Bhattacharya A, et al. Multiple brown tumors caused by a parathyroid adenoma mimicking metastatic bone disease from giant cell tumor. World J Nucl Med. 2016;15:56. https://doi.org/10.4103/1450-1147.167598.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Basaran Y, Ince S, Alagoz E, Meric C, Taslipinar A. An unusual presentation of primary hyperparathyroidism: multiple brown tumors and coexisting thyroid carcinoma. Rev Esp Med Nucl Imagen Mol. 2016;35:321–4. https://doi.org/10.1016/j.remn.2016.02.005.

    Article  CAS  PubMed  Google Scholar 

  36. García JR, Moro FJA, Bassa P, Soler M, Llinares E, Riera E. Brown tumors due to secondary hyperparathyroidism detected by 11C-choline PET/CT. Rev Esp Med Nucl Imagen Mol. 2016;35:209–10.

    PubMed  Google Scholar 

  37. Gahier Penhoat M, Drui D, Ansquer C, Mirallie E, Maugars Y, Guillot P. Contribution of 18-FDG PET/CT to brown tumor detection in a patient with primary hyperparathyroidism. Jt Bone Spine. 2017;84:209–12. https://doi.org/10.1016/j.jbspin.2016.06.007.

    Article  Google Scholar 

  38. Schnyder MA, Stolzmann P, Huber GF, Schmid C. A patient with a history of breast cancer and multiple bone lesions: a case report. J Med Case Rep. 2017. https://doi.org/10.1186/s13256-017-1296-1.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA. Benign bone conditions that may be FDG-avid and mimic malignancy. Semin Nucl Med. 2017;47:322–51. https://doi.org/10.1053/j.semnuclmed.2017.02.004.

    Article  PubMed  Google Scholar 

  40. Panagopoulos A, Tatani I, Kourea HP, Kokkalis ZT, Panagopoulos K, Megas P. Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report. J Med Case Rep. 2018. https://doi.org/10.1186/s13256-018-1723-y.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Amini Nezhad F, Payab M, Nayebandi S, Hasani-Ranjbar S. Jaw tumor in recurrent primary hyperparathyroidism: a case report. Int J Surg Case Rep. 2018;52:54–8. https://doi.org/10.1016/j.ijscr.2018.09.035.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Zhang-Yin J, Gaujoux S, Delbot T, Gauthé M, Talbot JN. 18F-fluorocholine PET/CT imaging of brown tumors in a patient with severe primary hyperparathyroidism. Clin Nucl Med. 2019;44:971–4. https://doi.org/10.1097/RLU.0000000000002814.

    Article  PubMed  Google Scholar 

  43. Tsushima Y, Sun S, Via MA. Brown tumors secondary to parathyroid carcinoma masquerading as skeletal metastases on 18F-FDG PET/CT: a case report. AACE Clin Case Rep. 2019;5:e230–2. https://doi.org/10.4158/ACCR-2018-0633.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Sen AE, Aydin Z, Kaya B, Sahin O. A benign pathology mimicking multiple bone metastasis on F-18 FDG-PET/CT: brown tumor. Selcuk Tip Derg. 2019;4:267–70. https://doi.org/10.30733/std.2019.01081.

    Article  Google Scholar 

  45. Bal J, Goel G, Tiwari A, Chawla M, Dougall P, Chaturvedi H. Case report—primary hyperparathyroidism with Brown tumors masquerading skeletal metastases—role of functional imaging in diagnosis and management. J Clin Transl Endocrinol Case Rep. 2019. https://doi.org/10.1016/j.jecr.2019.100054.

    Article  Google Scholar 

  46. Xie C, Tsakok M, Taylor N, Partington K. Imaging of brown tumours: a pictorial review. Insights Imaging. 2019. https://doi.org/10.1186/s13244-019-0757-z.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Graf C, Huellner M, Tschopp O, Bode-Lesniewska B, Schmid C. 18F-NaF-PET/CT in patients with primary hyperparathyroidism and brown tumors. J Bone Miner Metab. 2020;38:299–309. https://doi.org/10.1007/s00774-019-01059-z.

    Article  CAS  PubMed  Google Scholar 

  48. Kolodziej M, Saracyn M, Brodowska-Kania D, Niemczyk S, Kaminski G. The use of PET/CT with 11C-methionine for the diagnosis of a patient with renal hyperparathyroidism. Endocr Abstr. 2020;70(AEP161):112.

    Google Scholar 

  49. Xu B, Yu J, Lu Y, Han B. Primary hyperparathyroidism presenting as a brown tumor in the mandible: a case report. BMC Endocr Disord. 2020. https://doi.org/10.1186/s12902-019-0480-2.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Gosavi S, Kaur H, Gandhi P. Multifocal osteolytic lesions of jaw as a road map to diagnosis of brown tumor of hyperparathyroidism: a rare case report with review of literature. J Oral Maxillofac Pathol. 2020;24:S59-66. https://doi.org/10.4103/jomfp.JOMFP_319_19.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Pang Y, Shang Q, Meng T, Chen H. [68Ga]Ga-FAPI PET/CT imaging of brown tumors in a patient with primary hyperparathyroidism. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05648-x.

    Article  PubMed  Google Scholar 

  52. Al-Rasheed U, Barakat F, Al-Ibraheem A. Metabolic and functional imaging employment in the differentiation of brown tumors from bone metastases in a case of primary papillary thyroid cancer and parathyroid adenoma: case report. J Egypt Natl Canc Inst. 2021. https://doi.org/10.1186/s43046-021-00089-x.

    Article  PubMed  Google Scholar 

  53. Holzgreve A, Fabritius MP, Knösel T, Mittlmeier LM, Rübenthaler J, Tiling R, et al. Molecular imaging with 18f-fdg pet/ct and99mTc-MIBI SPECT/CT in osteitis fibrosa cystica generalisata. Diagnostics. 2021. https://doi.org/10.3390/diagnostics11081355.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Ilyicheva EA, Bersenev GA, Griroryev EG. The case of late diagnosis of giant parathyroid adenoma in combination with fibrocystic osteitis and brown tumor of the upper jaw: a case report. Probl Endokrinol (Mosk). 2021;67:49–56. https://doi.org/10.14341/PROBL12713.

    Article  PubMed  Google Scholar 

  55. Geysen A, Van Laere K, Verscuren R. Detection of unexpected brown tumors due to hyperparathyroidism diagnosed by 18F-FDG PET/CT. Clin Nucl Med. 2021;46:E16–7. https://doi.org/10.1097/RLU.0000000000003380.

    Article  PubMed  Google Scholar 

  56. Park PSU, Raynor WY, Sun Y, Werner TJ, Rajapakse CS, Alavi A. 18F-sodium fluoride pet as a diagnostic modality for metabolic, autoimmune, and osteogenic bone disorders: Cellular mechanisms and clinical applications. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22126504.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Diacinti D, Cipriani C, Biamonte F, Pepe J, Colangelo L, Kripa E, et al. Imaging technologies in the differential diagnosis and follow-up of brown tumor in primary hyperparathyroidism: Case report and review of the literature. Bone Rep. 2021. https://doi.org/10.1016/j.bonr.2020.100745.

    Article  PubMed  Google Scholar 

  58. Yamaga E, Fujioka T, Asakage T, Miura K, Tateishi U. 18F-FDG-detected Brown tumor confined to the maxillary bone with parathyroid adenoma. Clin Nucl Med. 2022;47:236–8. https://doi.org/10.1097/rlu.0000000000003897.

    Article  PubMed  Google Scholar 

  59. Yao X, Ou X. A case of brown tumor on 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT. Clin Nucl Med. 2022;47:88–9. https://doi.org/10.1097/RLU.0000000000003887.

    Article  PubMed  Google Scholar 

  60. Mazurek A, Dziuk M, Witkowska-Patena E, Chudzinski W, Piszczek S, Gizewska A, et al. The utility of 18F-fluorocholine PET/CT in the imaging of parathyroid adenomas. Endokrynol Pol. 2022;73:43–8. https://doi.org/10.5603/EP.a2021.0107.

    Article  CAS  PubMed  Google Scholar 

  61. Zhong Y, Huang Y, Luo J, Ye Y. Misdiagnosis of brown tumour caused by primary hyperparathyroidism: a case report with literature review. BMC Endocr Disord. 2022. https://doi.org/10.1186/s12902-022-00971-2.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Franco M, Bendini JC, Albano L, Barrillon D, Cassuto E, Bracco J. Radiographic follow-up of a phalangeal brown tumor. Radiology. 2002;131:339–40.

    Google Scholar 

  63. Doppman JL, Marx S, Spiegel A, Brown E, Downs R, Brennan MF, et al. Diagnostic radiology differential diagnosis of brown tumor vs. cystic osteitis by arteriography and computed tomography 1. Jt Bone Spine. 2002;69:506–10.

    Google Scholar 

  64. Takeshita T, Takeshita K, Abe S, Takami H, Imamura T, Furui S. Brown tumor with fluid-fluid levels in a patient with primary hyperparathyroidism: radiological findings. Radiat Med Med Imaging Radiat Oncol. 2006;24:631–4. https://doi.org/10.1007/s11604-006-0068-4.

    Article  Google Scholar 

  65. Jacquet-Francillon N, Granjon D, Casteillo F, Prévot N, Habouzit V. Incidental detection of a small cell lung cancer by 18F-choline PET/CT performed for recurrent hyperparathyroidism after parathyroidectomy. Clin Nucl Med. 2021;46:e109–11. https://doi.org/10.1097/RLU.0000000000003246.

    Article  PubMed  Google Scholar 

  66. Jacquet-Francillon N, Morelec I, Germain N, Prades J-M, Habouzit V, Mariat C, et al. Performance of quantitative measurements in [18 F]fluorocholine positron emission tomography/computed tomography for parathyroid imaging (P2TH study). Front Med. 2022. https://doi.org/10.3389/fmed.2022.956580.

    Article  Google Scholar 

  67. Macedo F, Ladeira K, Pinho F, Saraiva N, Bonito N, Pinto L, et al. Bone metastases: an overview. Oncol Rev. 2017. https://doi.org/10.4081/oncol.2017.321.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Migliorini F, Maffulli N, Trivellas A, Eschweiler J, Tingart M, Driessen A. Bone metastases: a comprehensive review of the literature. Mol Biol Rep. 2020;47:6337–45. https://doi.org/10.1007/s11033-020-05684-0.

    Article  CAS  PubMed  Google Scholar 

  69. Goltzman D. Osteolysis and cancer. J Clin Invest. 2001;107:1219–20. https://doi.org/10.1172/JCI13073.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Weng WW, Dong MJ, Zhang J, Yang J, Xu Q, Zhu YJ, et al. A systematic review of MRI, scintigraphy, FDG-PET and PET/CT for diagnosis of multiple myeloma related bone disease—which is best? Asian Pac J Cancer Prev. 2014;15:9879–84. https://doi.org/10.7314/APJCP.2014.15.22.9879.

    Article  PubMed  Google Scholar 

  71. Sachpekidis C, Hillengass J, Goldschmidt H, Wagner B, Haberkorn U, Kopka K, et al. Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation. Eur J Nucl Med Mol Imaging. 2017;44:50–62. https://doi.org/10.1007/s00259-016-3502-6.

    Article  CAS  PubMed  Google Scholar 

  72. Nanni C, Zamagni E, Cavo M, Rubello D, Tacchetti P, Pettinato C, et al. 11C-choline vs. 18F-FDG PET/CT in assessing bone involvement in patients with multiple myeloma. World J Surg Oncol. 2007. https://doi.org/10.1186/1477-7819-5-68.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Li M, Peng Z, Liu Q, Sun J, Yao S, Liu QI. Value of 11C-choline PET/CT for lung cancer diagnosis and the relation between choline metabolism and proliferation of cancer cells. Oncol Rep. 2013;29:205–11. https://doi.org/10.3892/or.2012.2099.

    Article  CAS  PubMed  Google Scholar 

  74. Rejnmark L, Ejlsmark-Svensson H. Effects of PTH and PTH hypersecretion on bone: a clinical perspective. Curr Osteoporos Rep. 2020;18:103–14. https://doi.org/10.1007/s11914-020-00574-7.

    Article  PubMed  Google Scholar 

  75. Crowe S, Cresswell K, Robertson A, Huby G, Avery A, Sheikh A. The case study approach. BMC Med Res Methodol. 2011. https://doi.org/10.1186/1471-2288-11-100.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Dwan K, Gamble C, Williamson PR, Kirkham JJ. Systematic review of the empirical evidence of study publication bias and outcome reporting bias—an updated review. PLoS ONE. 2013. https://doi.org/10.1371/journal.pone.0066844.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Nuclear Medicine Department, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Hopital Lyon Sud, 165 Chemin du Grand Revoyet, 69495, Pierre-Bénite, France

    Nicolas Jacquet-Francillon

  2. Department of Nuclear Medicine, University Hospital of Saint-Etienne, Saint-Étienne, France

    Nathalie Prevot

  3. Univ Jean Monnet, INSERM, U 1059 Sainbiose, 42023, Saint-Étienne, France

    Nathalie Prevot

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Jacquet-Francillon, N., Prevot, N. Brown tumors in nuclear medicine: a systematic review. Ann Nucl Med 37, 255–270 (2023). https://doi.org/10.1007/s12149-023-01832-1

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