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Radiological predictive factors on preoperative multimodality imaging are related to Oncotype DX recurrence score in estrogen-positive/human epidermal growth factor receptor 2-negative invasive breast cancer: a cross-sectional study

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Abstract

Objective

The Oncotype DX (ODX) estimates the 10-year risk of metastasis or recurrence of breast cancer and indicates whether chemotherapy is likely to be effective; however, the high cost of this test may limit its use for patients. The aim of this study was to evaluate the potential of preoperative imaging using mammography (MMG), ultrasonography (US), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and positron emission tomography/computed tomography (PET/CT) metabolic parameters in predicting the ODX recurrence score (ODXRS), which prognosticates estrogen receptor-positive (ER +)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer.

Methods

This retrospective study was conducted on 51 patients with ER+/ HER2− early-stage breast cancer with preoperative images available. Surgical specimens were sent for ODX assay and the ODXRS was categorized as low (<18) or intermediate/high (≥18). MMG/US findings were classified according to BI-RADS categories. For MRI analysis, tumor growth orientation was evaluated in addition to morphological assessment in BI-RADS. For PET/CT analysis, standardized uptake value (SUV) of the tumor were measured. Patient, tumor, and image characteristics were compared between the two groups, and predictors of the low ODXRS group were determined by logistic regression analysis. Two-sided P values less than 0.05 were considered statistically significant.

Results

Thirty-two (63%) and 19 (37%) patients were categorized as low and intermediate/high ODXRS, respectively. On univariate analysis, nuclear grade, tumor margin, and tumor growth orientation on MRI, and SUVmax on PET/CT were significantly associated with a low ODXRS. Multivariate analysis revealed that tumor growth orientation perpendicular to the Cooper’s ligament on MRI (P = 0.031) and a low SUVmax on PET/CT (P = 0.016) were independent prognostic factors for a low ODXRS. As a predictor of low ODXRS, the receiver operating characteristic (ROC) analysis of the SUVmax showed that using 3.0 as the optimal cut-off value has a sensitivity and specificity of 94.4% and 73.0%, respectively, with an area under the curve (AUC) of 0.923.

Conclusions

The combination of perpendicular tumor growth orientation to Cooper’s ligaments on MRI and a low SUVmax on PET/CT may predict a low ODXRS.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

Funding

No funding was received for this study.

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Authors and Affiliations

  1. Department of Surgery II, School of Medicine, Tokyo Women’s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Hiroko Tsukada, Eiichiro Noguchi & Takahiro Okamoto

  2. Department of Diagnostic Radiology, Keio University School of Medicine, 35, Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan

    Jitsuro Tsukada

  3. Department of Surgery, Yokohama Shinmidori General Hospital, 1726-7, Tokaichiba-cho, Midori-ku, Yokohama-shi, Kanagawa, 226-0025, Japan

    Tetsuya Ochi

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  1. Hiroko Tsukada
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  2. Jitsuro Tsukada
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  5. Takahiro Okamoto
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Tsukada, H., Tsukada, J., Ochi, T. et al. Radiological predictive factors on preoperative multimodality imaging are related to Oncotype DX recurrence score in estrogen-positive/human epidermal growth factor receptor 2-negative invasive breast cancer: a cross-sectional study. Ann Nucl Med 36, 853–864 (2022). https://doi.org/10.1007/s12149-022-01767-z

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  • DOI: https://doi.org/10.1007/s12149-022-01767-z

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