Skip to main content
SpringerLink
Log in

Evaluation of pleural lesions after pleurodesis with OK-432 by fluorodeoxyglucose-positron emission tomography/CT

  • Short Communication
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Objective

This study aimed to determine changes in FDG-PET/CT after pleurodesis with OK-432 and to investigate differences in the changes between non-malignant and malignant lesions.

Methods

Study participants were 17 patients with a history of malignant chest disease who underwent FDG-PET/CT after pleurodesis using OK-432 and in whom pleural lesions were determined to be non-malignant (n = 8) or malignant (n = 9). FDG uptake (SUVmax) was counted on all pleural lesions. CT findings (CT attenuation, shape) of pleural lesions with increased FDG uptake were evaluated.

Results

The number of patients with increased FDG uptake in the pleura differed significantly between the non-malignant group (3/8) and malignant group (9/9) (p < 0.01) The mean SUVmax of non-malignant lesions with increased FDG uptake was 2.3 ± 0.7 vs. 6.2 ± 2.2 in malignant lesions, for a significant difference (p < 0.01). The mean CT attenuation of lesions was 36 ± 11 HU in the non-malignant group and 34 ± 14 HU in the malignant group, a difference that was not significant (p = 0.91). There was a significant difference in nodular and linear shapes between non-malignant and malignant lesions (p < 0.01). All non-malignant lesions were linear.

Conclusions

Positive FDG uptake was shown in non-malignant pleural lesions as well as in malignant pleural lesions after pleurodesis using OK-432. Combined analysis of FDG accumulation and CT morphology is helpful to distinguish between benign and malignant lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Bethune N. Pleural poudrage: new technique for the deliberate production of pleural adhesion as preliminary to lobectomy. J Thorac Surg. 1935;4:251.

    Article  Google Scholar 

  2. Shaw P, Agarwal R. Pleurodesis for malignant pleural effusions. Cochrane Database Syst Rev. 2004;1:CD002916.

    Google Scholar 

  3. Yoshida K, Sugiura T, Takifuji N, Kawahara M, Matsui K, Kudoh S, et al. Randomized phase II trial of three intrapleural therapy regimens for the management of malignant pleural effusion in previously untreated non-small cell lung cancer: JCOG 9515. Lung Cancer. 2007;58(3):362–8.

    Article  Google Scholar 

  4. How CH, Tsai TM, Kuo SW, Huang PM, Hsu HH, Lee JM, et al. Chemical pleurodesis for prolonged postoperative air leak in primary spontaneous pneumothorax. J Formos Med Assoc. 2014;113(5):284–90.

    Article  CAS  Google Scholar 

  5. Bar-Shalom R, Yefremov N, Guralnik L, Gaitini D, Frenkel A, Kuten A, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med. 2003;44(8):1200–9.

    PubMed  Google Scholar 

  6. Narayanaswamy S, Kamath S, Williams M. CT appearances of talc pleurodesis. Clin Radiol. 2007;62(3):233–7.

    Article  CAS  Google Scholar 

  7. Peek H, van der Bruggen W, Limonard G. Pleural FDG uptake more than a decade after talc pleurodesis. Case Rep Med. 2009;2009:650864.

    Article  Google Scholar 

  8. Kwek BH, Aquino SL, Fischman AJ. Fluorodeoxyglucose positron emission tomography and CT after talc pleurodesis. Chest. 2004;125(6):2356–60.

    Article  Google Scholar 

  9. Ahmadzadehfar H, Palmedo H, Strunk H, Biersack HJ, Habibi E, Ezziddin S. False positive 18F-FDG-PET/CT in a patient after talc pleurodesis. Lung Cancer. 2007;58(3):418–21.

    Article  Google Scholar 

  10. Genestreti G, Moretti A, Piciucchi S, Giovannini N, Galassi R, Scarpi E, et al. FDG PET/CT response evaluation in malignant pleural mesothelioma patients treated with talc pleurodesis and chemotherapy. J Cancer. 2012;3:241–5.

    Article  Google Scholar 

  11. Kennedy L, Harley RA, Sahn SA, Strange C. Talc slurry pleurodesis. Pleural fluid and histologic analysis. Chest. 1995;107(6):1707–12.

    Article  CAS  Google Scholar 

  12. Kim BS, Kang H, Park JG. Pleural changes after talc pleurodesis in patients with underlying malignancy: comparison with recurrent malignant pleural lesions on CT and fluorodeoxyglucose-positron emission tomography/CT. J Korean Soc Radiol. 2014;70(1):35–41.

    Article  Google Scholar 

  13. Duysinx BC, Larock MP, Nguyen D, Corhay JL, Bury T, Hustinx R, et al. 18F-FDG PET imaging in assessing exudative pleural effusions. Nucl Med Commun. 2006;27(12):971–6.

    Article  Google Scholar 

  14. Muta F, Takamori S, Matsuo T, Iwasaki Y, Yoshiyama K, Shirouzu K. Changes in the pleural cavity by pleurodesis using talc or OK-432: an experimental study. Surg Today. 2011;41(1):111–4.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Miki Nishimori, Rika Yoshimatsu, Hitomi Iwasa, Kana Miyatake, Noriko Nitta & Takuji Yamagami

  2. Division of Thoracic Surgery, Department of Surgery, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Takashi Anayama

Authors
  1. Miki Nishimori
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rika Yoshimatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hitomi Iwasa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kana Miyatake
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Noriko Nitta
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takashi Anayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takuji Yamagami
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rika Yoshimatsu.

Ethics declarations

Conflicts of interest

The authors have no conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nishimori, M., Yoshimatsu, R., Iwasa, H. et al. Evaluation of pleural lesions after pleurodesis with OK-432 by fluorodeoxyglucose-positron emission tomography/CT. Ann Nucl Med 34, 793–798 (2020). https://doi.org/10.1007/s12149-020-01508-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12149-020-01508-0

Keywords

Search

Navigation