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Quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw: a preliminary study using volume-based parameters, comparison with chronic osteomyelitis

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Abstract

Objective

To investigate the quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw (MRONJ) using volume-based parameters.

Methods

Thirteen patients with mandibular lesions (nine MRONJ and four chronic osteomyelitis) underwent SPECT/CT acquisition at 4 h after injection of technetium 99m hydroxymethylene diphosphonate. Then, reconstruction of the acquired data and underwent voxel-based quantitative analysis using GI-BONE software. The parameters of the quantitative manner, such as maximum standardized uptake value (SUVmax), peak SUV (SUVpeak), mean SUV (SUVmean), metabolic bone volume (MBV) and total bone uptake (TBU), were compared for the mandibular lesions. Statistical analyses for the quantitative parameters of mandibular lesions were performed by Mann–Whitney U test. A p value lower than 0.05 was considered as statistically significant.

Results

Then, reconstruction of these quantitative parameters, SUVmax (10.16 ± 0.96), SUVpeak (7.95 ± 0.88), SUVmean (5.90 ± 0.86) and TBU (94.22 ± 57.44) for chronic osteomyelitis were significantly higher than those for MRONJ [5.50 ± 2.47 (p = 0.020), 4.10 ± 1.85 (p = 0.011), 2.74 ± 1.07 (p = 0.006) and 29.88 ± 15.46 (p = 0.034), respectively].

Conclusions

SUVmax, SUVpeak, SUVmean and TBU derived from bone SPECT/CT and voxel-based quantitative parameters may be useful for the evaluation of mandibular lesions, such as MRONJ and chronic osteomyelitis.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant number JP 18K09754.

Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan

    Ichiro Ogura & Hiroo Toshima

  2. Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

    Eizaburo Kobayashi

  3. Advanced Research Center, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

    Ken Nakahara

  4. Department of Life Science Dentistry, The Nippon Dental University, Niigata, Japan

    Kensuke Igarashi

  5. Department of Histology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

    Maiko Haga-Tsujimura

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  1. Ichiro Ogura
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  2. Eizaburo Kobayashi
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  3. Ken Nakahara
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  4. Kensuke Igarashi
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  5. Maiko Haga-Tsujimura
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  6. Hiroo Toshima
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Corresponding author

Correspondence to Ichiro Ogura.

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The authors declare that they have no conflict of interests.

Ethics approval

All the procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

All the patients gave their informed consent and the study was approved by the Ethics Committee of The Nippon Dental University School of Life Dentistry at Niigata, Japan (approved no. ECNG-R-318).

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Ogura, I., Kobayashi, E., Nakahara, K. et al. Quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw: a preliminary study using volume-based parameters, comparison with chronic osteomyelitis. Ann Nucl Med 33, 776–782 (2019). https://doi.org/10.1007/s12149-019-01390-5

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  • DOI: https://doi.org/10.1007/s12149-019-01390-5

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