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Evaluation of the effects of chemotherapy on brain glucose metabolism in children with Hodgkin’s lymphoma

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Abstract

Objective

Chemobrain is a recently proposed pathological entity. 18F-FDG PET/CT can show objective abnormalities to explain brain disorders caused by chemotherapy, although no study has investigated these phenomena in children to date. The main objective of the present study was to examine quantitatively the effects of chemotherapy on brain metabolism in a homogeneous population of children treated for Hodgkin's lymphoma using 18F-FDG PET/CT.

Methods

In this retrospective study, we included 20 children, newly diagnosed with Hodgkin’s lymphoma, who underwent 18F-FDG PET/CT at initial staging and at least one PET/CT in follow-up. The SPM12 software provided t-maps to show the difference in metabolism between these PET/CTs. The statistical maps were analyzed with xjView software to identify the brain regions associated with the clusters detected.

Results

Altered glucose metabolism was found in the frontal, cingular, and temporoinsular regions after two cycles of chemotherapy. Results in children were compared to a group of 35 adults. For the same statistical threshold, the extent and depth of the metabolic alterations were less in the adult group than in children.

Conclusions

18F-FDG PET/CT is useful in providing objective data to explain brain disorders caused by chemotherapy. This could lead to better care and should be compared to neuropsychological test results.

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Abbreviations

PET:

Positon emission tomography

CT:

Computed tomography

FDG:

Fluorodesoxyglucose

IQ:

Intelligence quotient

OEPA:

Vincristine, etoposide, prednisone and doxorubicin

ABVD:

Doxorubicin, bleomycin, vinblastine and dacarbazine

BEACOPP:

Bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisone

OSEM:

Ordered-subsets expectation maximization

MNI:

Montreal Neurological Institute

FWHM:

Full width at half maximum

FWE:

Family-wise error

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Authors and Affiliations

  1. Service de Biophysique Et de Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, 1, Avenue Molière, 67098, Strasbourg Cedex 09, France

    Alban Tauty, Izzie Jacques Namer & Caroline Bund

  2. ICube Université de Strasbourg/CNRS UMR 7357, Strasbourg, France

    Vincent Noblet, Izzie Jacques Namer & Caroline Bund

  3. Service D’Onco-hématologie Pédiatrique, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France

    Catherine Paillard

  4. Service d’Onco-hématologie, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France

    Luc-Matthieu Fornecker

  5. Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France

    Vincent Noblet, Catherine Paillard & Izzie Jacques Namer

Authors
  1. Alban Tauty
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  2. Vincent Noblet
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  3. Catherine Paillard
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  4. Luc-Matthieu Fornecker
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  5. Izzie Jacques Namer
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  6. Caroline Bund
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Correspondence to Caroline Bund.

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Tauty, A., Noblet, V., Paillard, C. et al. Evaluation of the effects of chemotherapy on brain glucose metabolism in children with Hodgkin’s lymphoma. Ann Nucl Med 33, 564–569 (2019). https://doi.org/10.1007/s12149-019-01363-8

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  • DOI: https://doi.org/10.1007/s12149-019-01363-8

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