Annals of Nuclear Medicine

, Volume 32, Issue 4, pp 281–287 | Cite as

Comparison of choline influx from dynamic 18F-Choline PET/CT and clinicopathological parameters in prostate cancer initial assessment

  • Xavier Palard-Novello
  • Anne-Lise Blin
  • David Bourhis
  • Etienne Garin
  • Pierre-Yves Salaün
  • Anne Devillers
  • Solène Querellou
  • Patrick Bourguet
  • Florence Le Jeune
  • Hervé Saint-Jalmes
Original Article



The aim of the study was to compare the kinetic analysis of 18F-labeled choline (FCH) uptake with static analysis and clinicopathological parameters in patients with newly diagnosed prostate cancer (PC).

Materials and methods

Sixty-one patients were included. PSA was performed few days before FCH PET/CT. Gleason scoring (GS) was collected from systematic sextant biopsies. FCH PET/CT consisted in a dual phase: early pelvic list-mode acquisition (from 0 to10 min post-injection) and late whole-body acquisition (60 min post-injection). PC volume of interest was drawn using an adaptative thresholding (40% of the maximal uptake) on the late acquisition and projected onto an early static frame of 10 min and each of the 20 reconstructed frames of 30 s. Kinetic analysis was performed using an imaging-derived plasma input function. Early kinetic parameter (K1 as influx) and static parameters (early SUVmean, late SUVmean, and retention index) were extracted and compared to clinicopathological parameters.


K1 was significantly, but moderately correlated with early SUVmean (r = 0.57, p < 0.001) and late SUVmean (r = 0.43, p < 0.001). K1, early SUVmean, and late SUVmean were moderately correlated with PSA level (respectively, r = 0.36, p = 0.004; r = 0.67, p < 0.001; r = 0.51, p < 0.001). Concerning GS, K1 was higher for patients with GS ≥ 4 + 3 than for patients with GS < 4 + 3 (median value 0.409 vs 0.272 min− 1, p < 0.001). No significant difference was observed for static parameters.


FCH influx index K1 seems to be related to GS and could be a non-invasive tool to gain further information concerning tumor aggressiveness.


18F-Choline Positron emission tomography Prostate cancer Kinetic analysis 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© The Japanese Society of Nuclear Medicine 2018

Authors and Affiliations

  • Xavier Palard-Novello
    • 1
    • 2
    • 3
  • Anne-Lise Blin
    • 1
    • 3
  • David Bourhis
    • 4
  • Etienne Garin
    • 1
    • 2
    • 5
  • Pierre-Yves Salaün
    • 4
    • 6
    • 7
  • Anne Devillers
    • 2
  • Solène Querellou
    • 4
    • 6
    • 7
  • Patrick Bourguet
    • 1
  • Florence Le Jeune
    • 1
    • 2
    • 8
  • Hervé Saint-Jalmes
    • 1
    • 2
    • 3
  1. 1.University of Rennes 1RennesFrance
  2. 2.Department of Nuclear MedicineCentre Eugène MarquisRennesFrance
  3. 3.UMR1099 INSERMRennesFrance
  4. 4.Department of Nuclear MedicineCentre Hospitalier UniversitaireBrestFrance
  5. 5.UMR 1241 INSERMRennesFrance
  6. 6.University of Bretagne OccidentaleBrestFrance
  7. 7.EA 3878BrestFrance
  8. 8.EA 4712RennesFrance

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