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18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging

Annals of Nuclear Medicine volume 32, pages 256–263 (2018)Cite this article

Abstract

Objective

Recently, a benzofuran derivative for the imaging of β-amyloid plaques, 5-(5-(2-(2-(2-18F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- N-methylpyridin-2-amine (18F-FPYBF-2) has been validated as a tracer for amyloid imaging and it was found that 18F-FPYBF-2 PET/CT is a useful and reliable diagnostic tool for the evaluation of AD (Higashi et al. Ann Nucl Med, https://doi.org/10.1007/s12149-018-1236-1, 2018). The aim of this study was to assess the biodistribution and radiation dosimetry of diagnostic dosages of 18F-FPYBF-2 in normal healthy volunteers as a first-in-man study.

Methods

Four normal healthy volunteers (male: 3, female: 1; mean age: 40 ± 17; age range 25–56) were included and underwent 18F-FPYBF-2 PET/CT study for the evaluation of radiation exposure and pharmacokinetics. A 10-min dynamic PET/CT scan of the body (chest and abdomen) was performed at 0–10 min and a 15-min whole-body static scan was performed six times after the injection of 18F-FPYBF-2. After reconstructing PET and CT image data, individual organ time–activity curves were estimated by fitting volume of interest data from the dynamic scan and whole-body scans. The OLINDA/EXM version 2.0 software was used to determine the whole-body effective doses.

Results

Dynamic PET imaging demonstrated that the hepatobiliary and renal systems were the principal pathways of clearance of 18F-FPYBF-2. High uptake in the liver and the gall bladder, the stomach, and the kidneys were demonstrated, followed by the intestines and the urinary bladder. The ED for the adult dosimetric model was estimated to be 8.48 ± 1.25 µSv/MBq. The higher absorbed doses were estimated for the liver (28.98 ± 12.49 and 36.21 ± 15.64 µGy/MBq), the brain (20.93 ± 4.56 and 23.05 ± 5.03µ Gy/MBq), the osteogenic cells (9.67 ± 1.67 and 10.29 ± 1.70 µGy/MBq), the small intestines (9.12 ± 2.61 and 11.12 ± 3.15 µGy/MBq), and the kidneys (7.81 ± 2.62 and 8.71 ± 2.90 µGy/MBq) for male and female, respectively.

Conclusions

The ED for the adult dosimetric model was similar to those of other agents used for amyloid PET imaging. The diagnostic dosage of 185–370 MBq of 18F-FPYBF-2 was considered to be acceptable for administration in patients as a diagnostic tool for the evaluation of AD.

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Acknowledgements

This work was supported by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for Next Generation World-Leading Researchers (NEXT Program, LS060),” initiated by the Council for Science and Technology Policy (CSTP).

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Authors and Affiliations

  1. Shiga Medical Center Research Institute, Moriyama, Japan

    Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Chio Okuyama, Yoshihiko Kishibe, Masaaki Takahashi & Hiroshi Yamauchi

  2. Dept. of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan

    Ryuichi Nishii, Tatsuya Higashi & Koichi Ishizu

  3. Dept. of Geriatric Medicine, Shiga General Hospital, Moriyama, Japan

    Tomoko Okina, Norio Suzuki & Hiroshi Hasegawa

  4. Kawasaki Memorial Hospital, Kawasaki, Japan

    Yasuhiro Nagahama

  5. Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Koichi Ishizu

  6. Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan

    Naoya Oishi

  7. Dept. of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan

    Hiroyuki Kimura

  8. Dept. of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    Hiroyuki Watanabe, Masahiro Ono & Hideo Saji

Authors
  1. Ryuichi Nishii
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  2. Tatsuya Higashi
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  3. Shinya Kagawa
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  6. Masaaki Takahashi
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  7. Tomoko Okina
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  10. Yasuhiro Nagahama
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  11. Koichi Ishizu
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  12. Naoya Oishi
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  13. Hiroyuki Kimura
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  14. Hiroyuki Watanabe
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  15. Masahiro Ono
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  16. Hideo Saji
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  17. Hiroshi Yamauchi
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Corresponding author

Correspondence to Tatsuya Higashi.

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Conflict of interest

No potential conflicts of interest were disclosed with regard to this study.

Additional information

This study is registered in UMIN Clinical Trials Registry (UMIN-CTR) as UMIN study ID: UMIN000010304, UMIN000012297, and UMIN000012299.

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Nishii, R., Higashi, T., Kagawa, S. et al. 18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging. Ann Nucl Med 32, 256–263 (2018). https://doi.org/10.1007/s12149-018-1240-5

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  • DOI: https://doi.org/10.1007/s12149-018-1240-5

Keywords

  • Alzheimer disease
  • Amyloid imaging
  • Normal healthy volunteers
  • Positron emission tomography
  • Biodistributtion
  • Radiation dosimetry
  • OLINDA/EXM