Annals of Nuclear Medicine

, Volume 32, Issue 3, pp 197–205 | Cite as

Relationship between collateral circulation and myocardial viability of 18F-FDG PET/CT subtended by chronic total occluded coronary arteries

  • Wei Dong
  • Jianan Li
  • Hongzhi Mi
  • Xiantao Song
  • Jian Jiao
  • Quan Li
Original Article



To analyze the relationship between the collateral flow of coronary chronic total occlusion (CTO) and myocardial viability detected by 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging.


A prospective analysis of 104 patients diagnosed by coronary angiography. All patients underwent resting myocardial perfusion imaging and PET/CT within 1 week. The collateral circulation was graded with Rentrop classification as no or poor collateral circulation in 16 CTO vessels, moderate collateral circulation in 34 CTO vessels, and good collateral circulation in 69 CTO vessels. Myocardial viability was determined with myocardial perfusion imaging and PET. The patterns were interpreted as mismatch, match and normal perfusion and 18F-FDG uptake.


There was no significant correlation between the severity and extent of perfusion defect, myocardial viability and collateral circulation grade. The myocardial viability was normal in mild and moderate hypokinetic regions and decreased in severe hypokinetic and akinesis–dyskinesis regions. The presence of collateral circulation was a sensitive (89%) but not a specific (31%) sign of myocardial viability.


In patients with CTO, collateral circulation does not seem to be an effective way for predicting myocardial viability. Further analysis of PET patterns of viable myocardium is needed to guide further revascularization and predict functional improvement and survival benefit.


18F-fluorodeoxyglucose Chronic total occlusion Positron emission tomography Collateral circulation Myocardial viability 



We are grateful to Feng Wang for their excellent technical support. The work described here has not been submitted anywhere else for potential publication.


Capital Clinical Characteristics Application Study (Z161100000516139). Beijing LiSheng Cardiovascular Health Foundation Pilot Fund Project (LHJJ20158521).

Compliance with ethical standards

Conflict of interest

No potential conflicts of interest were disclosed.


  1. 1.
    Sianos G, Werner GS, Galassi AR, Papafaklis MI, Escaned J, Hildick-Smith D, et al. Recanalisation of chronic total coronary occlusions: 2012 consensus document from the Euro CTO club. EuroIntervention. 2012;8:139 – 45.CrossRefPubMedGoogle Scholar
  2. 2.
    Fefer P, Knudtson ML, Cheema AN, Galbraith PD, Osherov AB, Yalonetsky S,et al. Current perspectives on coronary chronic total occlusions: the Canadian multicenter chronic total occlusions registry. J Am Coll Cardiol. 2012;59:991–7.CrossRefPubMedGoogle Scholar
  3. 3.
    Jeroudi OM, Alomar ME, Michael TT, El Sabbagh A, Patel VG, Mogabgab O, et al. Prevalence and management of coronary chronic total occlusions in a tertiary veterans affairs hospital. Catheter Cardiovasc Interv. 2014;84:637–43.CrossRefPubMedGoogle Scholar
  4. 4.
    Shah BN, Khattar RS, Senior R. The hibernating myocardium: current concepts, diagnostic dilemmas, and clinical challenges in the post-STICH era. Eur Heart J. 2013,34:1323–36.CrossRefPubMedGoogle Scholar
  5. 5.
    Kolh P, Windecker S, Alfonso F, Collet JP, Cremer J, Falk V, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: the Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI).Eur. J Cardiothorac Surg. 2014;46:517–92.CrossRefGoogle Scholar
  6. 6.
    Inaba Y, Chen JA, Bergmann SR. Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: a meta-analysis. J Nucl Cardiol, 2010;17:646–54.CrossRefPubMedGoogle Scholar
  7. 7.
    Werner GS, Ferrari M, Heinke S, Kuethe F, Surber R, Richartz BM, et al. Angiographic assessment of collateral connections in comparison with invasively determined collateral function in chronic coronary occlusions. Circulation. 2003;107:1972–7.CrossRefPubMedGoogle Scholar
  8. 8.
    Klocke FJ, Baird MG, Lorell BH, Bateman TM, Messer JV, Berman DS, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging–executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging. Circulation. 2003;108:1404–18.CrossRefPubMedGoogle Scholar
  9. 9.
    Safley DM, Koshy S, Grantham JA, Bybee KA, House JA, Kennedy KF, et al. Changes in myocardial ischemic burden following percutaneous coronary intervention of chronic total occlusions. Catheter Cardiovasc Interv. 2011;78:337 – 43.PubMedGoogle Scholar
  10. 10.
    Judkins MP. Selective coronary arteriography. I. A percutaneous transfemoral technic. Radiology. 1967;89:815–24.CrossRefPubMedGoogle Scholar
  11. 11.
    Rentrop KP, Cohen M, Blanke H, Phillips RA. Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol. 1985;5:587–92.CrossRefPubMedGoogle Scholar
  12. 12.
    Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical. Cardiol Am Heart Assoc Circ. 2002;105:539–42.Google Scholar
  13. 13.
    Fukai M, Ii M, Nakakoji T, Kawakatsu M, Nariyama J, Yokota N, et al. Angiographically demonstrated coronary collaterals predict residual viable myocardium in patients with chronic myocardial infarction: a regional metabolic study. J Cardiol. 2000;35:103–11.PubMedGoogle Scholar
  14. 14.
    Suero JA, Marso SP, Jones PG, Laster SB, Huber KC, Giorgi LV, et al. Procedural outcomes and long-term survival among patients undergoing percutaneous coronary intervention of a chronic total occlusion in native coronary arteries: a 20-year experience. J Am Coll Cardiol. 2001;38:409–14.CrossRefPubMedGoogle Scholar
  15. 15.
    Kumbasar D, Akyurek O, Dincer I, Atmaca Y, Kiliçkap M, Erol C,et al. Good collaterals predict viable myocardium. Angiology. 2007;58:550–5.CrossRefPubMedGoogle Scholar
  16. 16.
    Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999;100:1992–2002.CrossRefPubMedGoogle Scholar
  17. 17.
    Koszegi Z, Maes A, Piessens J, Van de Werf F, Mortelmans L. Segmental comparison between coronary angiography and positron emission tomography reveal slow predictive value of epicardial flow for viability. Eur Heart J. 1998;19:959–67.CrossRefPubMedGoogle Scholar
  18. 18.
    Al-Mohammad A, Norton MY, Welch AE, Walton S. Characterization of viability, scarring and hibernation of the myocardium supplied by epicardial coronary arteries with low flow grades. Nucl Med Commun. 2017;38:657–65.CrossRefPubMedGoogle Scholar
  19. 19.
    Di Carli M, Sherman T, Khanna S, Davidson M, Rokhsar S, Hawkins R,et al. Myocardial viability in asynergic regions subtended by occluded coronary arteries: relation to the status of collateral flow in patients with chronic coronary artery disease. J Am Coll Cardiol. 1994;23:860–8.CrossRefPubMedGoogle Scholar
  20. 20.
    Seiler C. The human collateral coronary circulation. Eur J Clin Invest. 2010;40:465–76.CrossRefPubMedGoogle Scholar
  21. 21.
    Arani DT, Greene DG, Bunnell IL, Smith GL, Klocke FJ. Reductions in coronary flow under resting conditions in collateral-dependent myocardium of patients with complete occlusion of the left anterior descending coronary artery. J Am Coll Cardiol. 1984;3:668–74.CrossRefPubMedGoogle Scholar
  22. 22.
    Galassi AR, Werner GS, Tomasello SD, Azzarelli S, Capodanno D, Barrano G, et al. Prognostic value of exercise myocardial scintigraphy in patients with coronary chronic total occlusions. J Interv Cardiol. 2010;23:139–48.CrossRefPubMedGoogle Scholar
  23. 23.
    Werner GS, Surber R, Ferrari M, Fritzenwanger M, Figulla HR. The functional reserve of collaterals supplying long-term chronic total coronary occlusions in patients without prior myocardial infarction. Eur Heart J. 2006;27:2406–2.CrossRefPubMedGoogle Scholar
  24. 24.
    Aboul-Enein F, Kar S, Hayes SW, Sciammarella M, Abidov A, Makkar R,et al. Influence of angiographic collateral circulation on myocardial perfusion in patients with chronic total occlusion of a single coronary artery and no prior myocardial infarction. J Nucl Med. 2004;45:950–5.PubMedGoogle Scholar
  25. 25.
    Muehling O, Jerosch-Herold M, Cyran C, Huber A, Schoenberg S, Reiser M, et al. Assessment of collateralized myocardium with cardiac magnetic resonance (CMR): transmural extent of infarction but not angiographic collateral vessel filling determines regional function and perfusion in collateral-dependent myocardium. Int J Cardiol. 2007;120:38–44.CrossRefPubMedGoogle Scholar
  26. 26.
    Vyssoulis G, Kyriakidis M, Karpanou E, Kyriakidis C, Sfikakis P, Barbetseas J, et al. A prospective angiographic study of the coronary collateral circulation in coronary arterial disease. Int J Cardiol. 1990;27:187 – 91.CrossRefPubMedGoogle Scholar

Copyright information

© The Japanese Society of Nuclear Medicine 2018

Authors and Affiliations

  1. 1.Department of Nuclear Medicine, Beijing Anzhen HospitalCapital Medical UniversityBeijingChina
  2. 2.Department of Cardiology, Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

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