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A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [18F]THK5351 and [11C]PIB

Annals of Nuclear Medicine volume 31, pages 563–569 (2017)Cite this article

Abstract

Purpose

To suppress partial volume effect (PVE) in brain PET, there have been many algorithms proposed. However, each methodology has different property due to its assumption and algorithms. Our aim of this study was to investigate the difference among partial volume correction (PVC) method for tau and amyloid PET study.

Methods

We investigated two of the most commonly used PVC methods, Müller-Gärtner (MG) and geometric transfer matrix (GTM) and also other three methods for clinical tau and amyloid PET imaging. One healthy control (HC) and one Alzheimer’s disease (AD) PET studies of both [18F]THK5351 and [11C]PIB were performed using a Eminence STARGATE scanner (Shimadzu Inc., Kyoto, Japan). All PET images were corrected for PVE by MG, GTM, Labbé (LABBE), Regional voxel-based (RBV), and Iterative Yang (IY) methods, with segmented or parcellated anatomical information processed by FreeSurfer, derived from individual MR images. PVC results of 5 algorithms were compared with the uncorrected data.

Results

In regions of high uptake of [18F]THK5351 and [11C]PIB, different PVCs demonstrated different SUVRs. The degree of difference between PVE uncorrected and corrected depends on not only PVC algorithm but also type of tracer and subject condition.

Conclusion

Presented PVC methods are straight-forward to implement but the corrected images require careful interpretation as different methods result in different levels of recovery.

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Acknowledgements

This study was supported by research funds from GE Healthcare and Grants-in-Aid of Scientific research (C) (No. 15K08687), Grant-in-Aid for Scientific Research (B) (No. 15H04900) and Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control) (No. 26117003) from the Ministry of Education, Culture, Sports, Science and Technology, Japanese Government.

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Affiliations

  1. Department of Medical Physics, Tohoku University Graduate School of Medicine, Sendai, Japan

    Miho Shidahara, Senri Oyama & Kohsuke Gonda

  2. Division of Cyclotron, Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan

    Miho Shidahara, Shoichi Watanuki & Manabu Tashiro

  3. A*STAR-NUS Clinical Imaging Research Centre, Singapore, Singapore

    Benjamin A. Thomas

  4. Institute of Nuclear Medicine, University College London, London, UK

    Benjamin A. Thomas

  5. Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

    Nobuyuki Okamura

  6. Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan

    Masanobu Ibaraki & Keisuke Matsubara

  7. Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan

    Yoichi Ishikawa, Ren Iwata & Shozo Furumoto

  8. Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan

    Kazuhiko Yanai

  9. Division of Radiation Protection and Safety Control, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan

    Hiroshi Watabe

Authors
  1. Miho Shidahara
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  2. Benjamin A. Thomas
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  3. Nobuyuki Okamura
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  4. Masanobu Ibaraki
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  5. Keisuke Matsubara
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  6. Senri Oyama
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  7. Yoichi Ishikawa
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  9. Ren Iwata
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  10. Shozo Furumoto
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  11. Manabu Tashiro
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  12. Kazuhiko Yanai
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  13. Kohsuke Gonda
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  14. Hiroshi Watabe
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Corresponding author

Correspondence to Miho Shidahara.

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Shidahara, M., Thomas, B.A., Okamura, N. et al. A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [18F]THK5351 and [11C]PIB. Ann Nucl Med 31, 563–569 (2017). https://doi.org/10.1007/s12149-017-1185-0

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  • DOI: https://doi.org/10.1007/s12149-017-1185-0

Keywords

  • Partial volume correction
  • Tau PET
  • Image processing
  • [18F]THK5351