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Regional myocardial damage and active inflammation in patients with cardiac sarcoidosis detected by non-invasive multi-modal imaging

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Abstract

Aims

Cardiac sarcoidosis (CS) can be diagnosed using 18F-FDG-PET/CT (PET), cardiovascular magnetic resonance (CMR), and 123I-BMIPP/201TlCl dual myocardial SPECT. This study aims to clarify the relationships among the three modalities with respect to CS.

Methods and results

We evaluated 16 patients (male n = 11; age 55 ± 13 years) with confirmed CS who underwent PET, CMR, and dual SPECT with gated SPECT before starting steroid therapy. The left ventricular myocardium was divided into 17 segments to obtain SUVmax for PET images, defect scores from 0 to 4 (0 normal; 4 absent), and mismatch scores for dual SPECT (BMDS, TLDS, and MS) images and late gadolinium enhancement (LGE) scores (0 none; 1 partly positive; 2 homogeneous) on CMR images. Summed BMDS, TLDS, and MS were 18.6 ± 12.6, 12.9 ± 10.9, and 5.7 ± 3.1, respectively. The segmental BMDS and TLDS scores became significantly higher as the LGE scores increased. The MS scores were significantly higher in areas of LGE with a score of 1 than 0 (both, p < 0.001), but did not significantly differ between areas with LGE scores of 1 and 2. The SUVmax was significantly higher in LGE areas with a score of 1 than 0 (p < 0.025), but did not significantly differ between those with scores of 1 or 2.

Conclusion

Regions with a higher SUVmax indicating active myocardial inflammation were mainly located in areas with LGE, where BMIPP and TL mismatches were evident in patients with CS.

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Authors and Affiliations

  1. Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan

    Shohei Kataoka, Naoki Serizawa, Atsushi Suzuki & Nobuhisa Hagiwara

  2. Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Mitsuru Momose, Kenji Fukushima, Chisato Kondo, Koichiro Abe & Shuji Sakai

Authors
  1. Shohei Kataoka
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  2. Mitsuru Momose
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  3. Kenji Fukushima
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  4. Naoki Serizawa
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  5. Atsushi Suzuki
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  6. Chisato Kondo
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  9. Nobuhisa Hagiwara
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Correspondence to Mitsuru Momose.

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All procedures performed involving human participants were in accordance with the ethical standards of the institutional research committee.

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Kataoka, S., Momose, M., Fukushima, K. et al. Regional myocardial damage and active inflammation in patients with cardiac sarcoidosis detected by non-invasive multi-modal imaging. Ann Nucl Med 31, 135–143 (2017). https://doi.org/10.1007/s12149-016-1136-1

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  • DOI: https://doi.org/10.1007/s12149-016-1136-1

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