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A novel respiratory gating method for oncologic positron emission tomography based on bioimpedance approach

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Abstract

Objective

Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts.

Methods

The bioimpedance-based respiratory gating method was studied parallel to a clinically used respiratory gating method [Real-time Position Management by Varian Medical Systems] in 4D PET/CT acquisition of 9 oncologic patients. The quantitative analysis consisted of the evaluation of tumour SUVpeak, SUVmax and volume. Additionally, target-to-background ratios as well as motion in cranial–caudal and anterior–posterior directions were measured. The evaluation was performed with amplitude- and time-based gating using averaged attenuation correction maps.

Results

Bioimpedance gating resulted in 17.7–18.9 % increase in mean SUVpeak and 20.0–21.4 % decrease in mean volume compared to non-gated images. The maximum motion measured from the bioimpedance-gated images was 19 mm in cranial–caudal direction and 9 mm in anterior–posterior direction.

Conclusions

Bioimpedance-based respiratory gating compensates the adverse effects of motion in oncologic PET imaging.

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Acknowledgments

The study was conducted within the Finnish Center of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research supported by the Academy of Finland, University of Turku, Turku University Hospital and Åbo Akademi University. The authors thank GE Healthcare for providing offline reconstruction for gating (RGT software) according to a research agreement between GE Healthcare and Turku PET Centre. Jarmo Teuho worked as an employee of GE Healthcare at a time when majority of work was completed as a part of research collaboration. This work was funded by Kuopio University Hospital (EVO, project 5031345), Academy of Finland (International Doctoral Programme in Biomedical Engineering and Medical Physics), Oskar Öflunds Stiftelse, Instrumentarium Science Foundation and Finnish Cultural Foundation North Savo Regional Fund.

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Authors and Affiliations

  1. Diagnostic Imaging Centre, Kuopio University Hospital, Kuopio, Finland

    Tuomas Koivumäki & Mikko A. Hakulinen

  2. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

    Tuomas Koivumäki & Marko Vauhkonen

  3. GE Healthcare, Helsinki, Finland

    Jarmo Teuho

  4. PET Centre, University of Turku and Turku University Hospital, Turku, Finland

    Jarmo Teuho & Mika Teräs

Authors
  1. Tuomas Koivumäki
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  2. Jarmo Teuho
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  3. Mika Teräs
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  4. Marko Vauhkonen
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  5. Mikko A. Hakulinen
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Correspondence to Tuomas Koivumäki.

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Koivumäki, T., Teuho, J., Teräs, M. et al. A novel respiratory gating method for oncologic positron emission tomography based on bioimpedance approach. Ann Nucl Med 29, 351–358 (2015). https://doi.org/10.1007/s12149-015-0953-y

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  • DOI: https://doi.org/10.1007/s12149-015-0953-y

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