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A performance comparison of novel cadmium–zinc–telluride camera and conventional SPECT/CT using anthropomorphic torso phantom and water bags to simulate soft tissue and breast attenuation

Annals of Nuclear Medicine volume 29, pages 342–350 (2015)Cite this article

Abstract

Purposes

This study was aimed to compare the physical performances of cadmium–zinc–telluride (CZT) camera and conventional Anger camera. An anthropomorphic torso phantom and water bags to simulate breasts were used to evaluate artifacts arising from soft tissue attenuation.

Materials and methods

Linear source studies were performed to evaluate extrinsic resolution of CZT camera (Discovery NM 530c, GE) and conventional single-photon emission computed tomography (SPECT) Anger camera (Symbia T2, Siemens). Three sets of phantom experiments: cardiac phantom only (phantom H), anthropomorphic torso phantom added (phantom T), and torso phantom with water bags attached (phantom B), with Tc-99m were performed on both scanners. Imaging performances were evaluated through count sensitivity, contrast-to-noise ratio, quantitative sharpness profile, wall thickness, perfusion uniformity (measured by standard deviation of perfusion percentage of 20 segments using quantitative perfusion SPECT (QPS) software, Cedars-Sinai), and visual imaging quality (using 20-segment sum defect scores (SDS) of QPS) for CZT camera, conventional SPECT without and with computed tomography transmission attenuation correction (AC).

Results

CZT cameras had higher extrinsic resolution than conventional SPECT. Myocardium count sensitivity of CZT camera is about threefold of conventional SPECT. Contrast-to-noise ratios and sharpness profiles are higher on CZT camera but degraded while extracardiac soft tissue presented. Myocardial walls measured on CZT images were thicker. Images of CZT had lower SDS, while AC reduced the differences of SDS between CZT and CC. Perfusion images from CZT had the better uniformity than SPECT without or with AC. Breast attenuation was less prominent on CZT camera than conventional SPECT, while inferior and inferolateral segments still suffer marked soft tissue attenuation on CZT camera.

Conclusions

CZT camera has better physical performance and image quality with less artificial perfusion defects than conventional SPECT. CZT camera also has less breast attenuation than conventional SPECT. However, extracardiac soft tissue may degrade the superior performance of CZT camera, and attenuation correction methods are still needed to solve the attenuation issues in inferior and inferolateral myocardium.

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References

  1. Verger A, Djaballah W, Fourquet N, Rouzet F, Koehl G, Imbert L, et al. Comparison between stress myocardial perfusion SPECT recorded with cadmium–zinc–telluride and Anger cameras in various study protocols. Eur J Nucl Med Mol Imaging. 2013;40:331–40.

    Article  CAS  PubMed  Google Scholar 

  2. Imbert L, Poussier S, Franken PR, Songy B, Verger A, Morel O, et al. Compared performance of high-sensitivity cameras dedicated to myocardial perfusion SPECT: a comprehensive analysis of phantom and human images. J Nucl Med. 2012;53:1897–903.

    Article  PubMed  Google Scholar 

  3. Tanaka H, Chikamori T, Hida S, Uchida K, Igarashi Y, Yokoyama T, et al. Comparison of myocardial perfusion imaging between the new high-speed gamma camera and the standard anger camera. Circ J. 2013;77:1009–17.

    Article  CAS  PubMed  Google Scholar 

  4. Songy B, Lussato D, Guernou M, Queneau M, Geronazzo R. Comparison of myocardial perfusion imaging using thallium-201 between a new cadmium–zinc–telluride cardiac camera and a conventional SPECT camera. Clin Nucl Med. 2011;36:776–80.

    Article  PubMed  Google Scholar 

  5. Buechel RR, Herzog BA, Husmann L, Burger IA, Pazhenkottil AP, Treyer V, et al. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation. Eur J Nucl Med Mol Imaging. 2010;37:773–8.

    Article  PubMed  Google Scholar 

  6. Esteves FP, Raggi P, Folks RD, Keidar Z, Askew JW, Rispler S, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras. J Nucl Cardiol. 2009;16:927–34.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Sharir T, Ben-Haim S, Merzon K, Prochorov V, Dickman D, Berman DS. High-speed myocardial perfusion imaging initial clinical comparison with conventional dual detector anger camera imaging. JACC Cardiovasc Imaging. 2008;1:156–63.

    Article  PubMed  Google Scholar 

  8. Gimelli A, Bottai M, Giorgetti A, Genovesi D, Kusch A, Ripoli A, et al. Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study. Circ Cardiovasc Imaging. 2011;4:51–8.

    Article  PubMed  Google Scholar 

  9. Nakazato R, Berman DS, Hayes SW, Fish M, Padgett R, Xu Y, et al. Myocardial perfusion imaging with a solid-state camera: simulation of a very low dose imaging protocol. J Nucl Med. 2013;54:373–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Oddstig J, Hedeer F, Jogi J, Carlsson M, Hindorf C, Engblom H. Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera. J Nucl Cardiol. 2013;20:38–44.

    Article  PubMed  Google Scholar 

  11. Songy B, Guernou M, Lussato D, Queneau M, Geronazzo R. Low-dose thallium-201 protocol with a cadmium–zinc–telluride cardiac camera. Nucl Med Commun. 2012;33:464–9.

    Article  CAS  PubMed  Google Scholar 

  12. Gimelli A, Bottai M, Genovesi D, Giorgetti A, Di Martino F, Marzullo P. High diagnostic accuracy of low-dose gated-SPECT with solid-state ultrafast detectors: preliminary clinical results. Eur J Nucl Med Mol Imaging. 2012;39:83–90.

    Article  CAS  PubMed  Google Scholar 

  13. Nkoulou R, Pazhenkottil AP, Kuest SM, Ghadri JR, Wolfrum M, Husmann L, et al. Semiconductor detectors allow low-dose-low-dose 1-day SPECT myocardial perfusion imaging. J Nucl Med. 2011;52:1204–9.

    Article  PubMed  Google Scholar 

  14. Duvall WL, Croft LB, Godiwala T, Ginsberg E, George T, Henzlova MJ. Reduced isotope dose with rapid SPECT MPI imaging: initial experience with a CZT SPECT camera. J Nucl Cardiol. 2010;17:1009–14.

    Article  PubMed  Google Scholar 

  15. Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18:847–57.

    Article  PubMed  Google Scholar 

  16. Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ. Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: comparison to coronary angiography. J Nucl Cardiol. 2012;19:19–27.

    Article  PubMed  Google Scholar 

  17. Duvall WL, Sweeny JM, Croft LB, Barghash MH, Kulkarni NK, Guma KA, et al. Comparison of high efficiency CZT SPECT MPI to coronary angiography. J Nucl Cardiol. 2011;18:595–604.

    Article  PubMed  Google Scholar 

  18. Takahashi Y, Miyagawa M, Nishiyama Y, Ishimura H, Mochizuki T. Performance of a semiconductor SPECT system: comparison with a conventional Anger-type SPECT instrument. Ann Nucl Med. 2013;27:11–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. Herzog BA, Buechel RR, Katz R, Brueckner M, Husmann L, Burger IA, et al. Nuclear myocardial perfusion imaging with a cadmium–zinc–telluride detector technique: optimized protocol for scan time reduction. J Nucl Med. 2010;51:46–51.

    Article  PubMed  Google Scholar 

  20. Hindorf C, Oddstig J, Hedeer F, Hansson MJ, Jogi J, Engblom H. Importance of correct patient positioning in myocardial perfusion SPECT when using a CZT camera. J Nucl Cardiol. 2014;21:695–702.

    Article  PubMed  Google Scholar 

  21. Fiechter M, Gebhard C, Fuchs TA, Ghadri JR, Stehli J, Kazakauskaite E, et al. Cadmium–zinc–telluride myocardial perfusion imaging in obese patients. J Nucl Med. 2012;53:1401–6.

    Article  CAS  PubMed  Google Scholar 

  22. Gimelli A, Bottai M, Giorgetti A, Genovesi D, Filidei E, Marzullo P. Evaluation of ischaemia in obese patients: feasibility and accuracy of a low-dose protocol with a cadmium–zinc telluride camera. Eur J Nucl Med Mol Imaging. 2012;39:1254–61.

    Article  CAS  PubMed  Google Scholar 

  23. Herzog BA, Buechel RR, Husmann L, Pazhenkottil AP, Burger IA, Wolfrum M, et al. Validation of CT attenuation correction for high-speed myocardial perfusion imaging using a novel cadmium–zinc–telluride detector technique. J Nucl Med. 2010;51:1539–44.

    Article  PubMed  Google Scholar 

  24. Mouden M, Timmer JR, Ottervanger JP, Reiffers S, Oostdijk AH, Knollema S, et al. Impact of a new ultrafast CZT SPECT camera for myocardial perfusion imaging: fewer equivocal results and lower radiation dose. Eur J Nucl Med Mol Imaging. 2012;39:1048–55.

    Article  PubMed  Google Scholar 

  25. Fiechter M, Ghadri JR, Kuest SM, Pazhenkottil AP, Wolfrum M, Nkoulou RN, et al. Nuclear myocardial perfusion imaging with a novel cadmium–zinc–telluride detector SPECT/CT device: first validation versus invasive coronary angiography. Eur J Nucl Med Mol Imaging. 2011;38:2025–30.

    Article  CAS  PubMed  Google Scholar 

  26. Buechel RR, Pazhenkottil AP, Herzog BA, Husmann L, Nkoulou RN, Burger IA, et al. Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium–zinc–telluride detector gamma camera. Eur J Nucl Med Mol Imaging. 2010;37:1903–8.

    Article  PubMed  Google Scholar 

  27. Gimelli A, Bottai M, Quaranta A, Giorgetti A, Genovesi D, Marzullo P. Gender differences in the evaluation of coronary artery disease with a cadmium–zinc telluride camera. Eur J Nucl Med Mol Imaging. 2013;40:1542–8.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The study was supported in part by grant NTUH.104-N01 from the National Taiwan University Hospital, Taipei, Taiwan.

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Affiliations

  1. Department of Nuclear Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan

    Chia-Ju Liu, Ju-Shin Cheng, Yi-Chieh Chen, Yih-Hwen Huang & Ruoh-Fang Yen

  2. Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

    Ruoh-Fang Yen

Authors
  1. Chia-Ju Liu
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  2. Ju-Shin Cheng
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Correspondence to Ruoh-Fang Yen.

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Liu, CJ., Cheng, JS., Chen, YC. et al. A performance comparison of novel cadmium–zinc–telluride camera and conventional SPECT/CT using anthropomorphic torso phantom and water bags to simulate soft tissue and breast attenuation. Ann Nucl Med 29, 342–350 (2015). https://doi.org/10.1007/s12149-015-0952-z

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  • DOI: https://doi.org/10.1007/s12149-015-0952-z

Keywords

  • Myocardial perfusion imaging
  • CZT camera
  • Conventional SPECT
  • Soft tissue attenuation