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The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusion-gated SPECT

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Abstract

Purpose

Hypertension is one of the most important risk factors for cardiovascular disease. However, hypertension may also result in left ventricular dyssynchrony (LVD) which is characterized by delayed activation of certain ventricular segments leading to uncoordinated contraction. The aim of this study was to evaluate the LVD measured by phase analysis of gated single-photon emission computed tomography (SPECT) imaging in patients with hypertension.

Methods

We retrospectively reviewed the records of the patients who have referred to our institution for myocardial perfusion imaging (MPI) with a diagnosis of cardiovascular disease. In this study, total of 196 patients (127 females and 69 males, with a mean age of 59.62 ± 10.27 years) with and without hypertension (123 and 73, respectively) were included. Phase analysis parameters were compared in patients with and without hypertension which are derived using Emory Cardiac Toolbox. Among these 196 patients, 72 had echocardiography results. The findings of echocardiographic and phase analysis were also compared. Student’s t test, Kruskal–Wallis, Mann–Whitney U test and Spearman correlation test were used to compare the results.

Results

There were statistically significant differences in the phase standard deviation (p = 0.005) and histogram bandwidth (p < 0.001) parameters of the phase analysis between the patients with and without hypertension groups, respectively. Furthermore, echocardiographic findings were significantly correlated with the result of the phase analysis.

Conclusion

This study suggested that routine use of phase analysis-gated SPECT imaging will be beneficial for the diagnosis of LVD.

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Abbreviations

ASH:

Asymmetrical septal hypertrophy

DM:

Diabetes mellitus

HT:

Hypertension

LVD:

Left ventricular dyssynchrony

LVEF:

Left ventricular ejection fraction

LVH:

Left ventricular hypertrophy

LVPW:

Left ventricular posterior wall

IVS:

Interventricular septum

MPI:

Myocardial perfusion imaging

PHB:

Phase histogram bandwidth

PSD:

Phase standard deviation

SDS:

Summed difference score

SMS:

Summed motion score

SRS:

Summed rest score

SSS:

Summed stress score

STS:

Summed thickening score

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Conflict of interest

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Authors and Affiliations

  1. Department of Nuclear Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey

    Semra Ozdemir, Yusuf Ziya Tan & Fatmanur Çelik

  2. Department of Cardiology, Faculty of Medicine, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey

    Bahadır Kırılmaz & Ahmet Barutçu

  3. Department of Biostatistics, Faculty of Medicine, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey

    Semra Akgoz

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  1. Semra Ozdemir
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  2. Bahadır Kırılmaz
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Correspondence to Semra Ozdemir.

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Ozdemir, S., Kırılmaz, B., Barutçu, A. et al. The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusion-gated SPECT. Ann Nucl Med 29, 240–247 (2015). https://doi.org/10.1007/s12149-014-0933-7

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  • DOI: https://doi.org/10.1007/s12149-014-0933-7

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