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Annals of Nuclear Medicine

, Volume 28, Issue 9, pp 880–890 | Cite as

Synthesis, characterization and in vivo evaluation of [62Zn]–benzo-δ-sultam complex as a possible pet imaging agent

  • Mehdi Ghandi
  • Shahzad Feizi
  • Farhood Ziaie
  • Yousef FazaeliEmail author
  • Behrooz Notash
Original Article

Abstract

Objective

The development of a new tracer based on the cyclic sulfonamides (sultams) was investigated.

Methods

3-(Methoxy-phenyl-methyl)-1,6-dimethyl-1H benzo[c][1,2] thiazine 2,2-dioxide (benzo-δ-sultam) was synthesized and characterized by elemental analysis, FT-IR spectroscopy and single crystal X-ray structure determination. The prepared cyclic sulfonamide was labeled with non-commercial 62Zn radioisotope for fast in vivo targeting and Coincidence imaging purposes (radiochemical purity 97 % ITLC, 96 % HPLC, specific activity 20–23 GBq/mmol). In vivo biodistribution of the final complex was investigated in Sprague Dawley® rats bearing fibro sarcoma tumor after 2, 4 and 8 h post injection and compared with free Zn+2 cation.

Results

Using instant paper chromatography method, the physicochemical properties of labeled compounds were found sufficiently stable in organic phases, e.g. a human serum, to be reliably used in bioapplications.

Conclusions

The complex exhibited a rapid as well as high tumor uptake (tumor to blood ratio 4.38 and tumor to muscle ratio 9.63) resulting in an efficient tumor targeting agent.

Keywords

62Zn production Benzo-δ-sultam Coincidence imaging Bio distribution 

Notes

Conflict of interest

The authors report no conflicts of interest in this work.

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Copyright information

© The Japanese Society of Nuclear Medicine 2014

Authors and Affiliations

  • Mehdi Ghandi
    • 1
  • Shahzad Feizi
    • 1
    • 2
  • Farhood Ziaie
    • 2
  • Yousef Fazaeli
    • 2
    Email author
  • Behrooz Notash
    • 3
  1. 1.School of Chemistry, College of ScienceUniversity of TehranTehranIran
  2. 2.Nuclear Science and Technology Research Institute (NSTRI)KarajIran
  3. 3.Department of ChemistryShahid Beheshti University, G. C. EvinTehranIran

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