Abstract
Objective
The objective of this study was to investigate the predictive role of volumetric parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by F-18 FDG PET/CT for regional lymph node (rLN) metastasis in rectal cancer patients.
Methods
Retrospectively, 74 rectal cancer patients were enrolled. All patients received surgical treatment and F-18 FDG PET/CT at diagnosis. The F-18 FDG PET/CT findings of primary cancer and rLN involvement were compared with the pathologic diagnosis within 5 weeks after operation. Univariate and multivariate analyses were used to analyze the associations among the pathologic LN status and age, sex, T stage, AJCC stage, SUVmax, lymphatic invasion, venous invasion, neural invasion, and volumetric parameters.
Results
The LN (+) group showed statistically significant higher values of MTV2.5 (p < 0.0001), MTV3 (p < 0.0001), MTV3.5 (p = 0.0001), TLG2.5 (p = 0.0007), TLG3 (p = 0.0011), and TLG3.5 (p = 0.0024). In univariate analysis, T stage, AJCC stage, neural invasion, and volumetric parameters were factors significantly associated with pathologic LN involvement. However, in multivariate analysis, advanced T stage, high AJCC stage, MTV2.5, and TLG2.5 were associated with pathologic LN involvement in rectal cancer.
Conclusion
This study showed that, not only T stage and AJCC stage, but also volumetric parameters such as MTV2.5 and TLG2.5 are useful factors for the prediction of pathologic LN status in rectal cancer patients.
Similar content being viewed by others
References
Naishadam D, Siegel R, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11–30.
O`Dwyer ST, Haboubi NY, Johnson JS, Gardy R. Detection of lymph node metastases in colorectal carcinoma. Colorectal Dis. 2001;3:288–94.
Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J. Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging- a meta-analysis. Radiology. 2004;232:773–83.
Shin SS, Jeong YY, Min JJ, Kim HR, Chung TW, Kang HK. Preoperative staging of colorectal cancer: CT versus integrated FDG PET/CT. Abdom Imaging. 2008;33:270–7.
Choi BW, Zeon SK, Kim SH, Jo I, Kim HW, Won KS. Significance of SUV on follow-up F-18 FDG PET at the anastomotic site of gastroduodenostomy after distal gastrectomy in patients with gastric cancer. Nucl Med Mol Imaging. 2011;45:285–90.
Song BI, Hong CM, Lee HJ, Kang S, Jeong SY, Kim HW, et al. Prognostic value of primary tumor uptake on F-18 FDG PET/CT in patients with invasive ductal breast cancer. Nucl Med Mol Imaging. 2011;45:117–24.
Lee M, Lee Y, Hwang KH, Choe W, Park CY. Usefulness of F-18 FDG PET/CT in assessment of recurrence of cervical cancer after treatment. Nucl Med Mol Imaging. 2011;45:111–6.
Kim SH, Won KS, Choi BW, Choi BW, Zeon SK, Chung WJ, et al. Usefulness of F-18 FDG PET/CT in the evaluation of early treatment response after interventional therapy for hepatocellular carcinoma. Nucl Med Mol Imaging. 2012;46:102–10.
Hyun SH, Choi JY, Shim YM, Kim K, Lee SJ, Cho YS, et al. Prognostic value of metabolic tumor volume measured by 18F-fluorodeoxyglucose positron emission tomography in patients with esophageal carcinoma. Ann Surg Oncol. 2010;17:115–22.
Yoo J, Choi JY, Lee KT, Heo JS, Park SB, Moon SH, et al. Prognostic significance of volume-based metabolic parameters by 18F-FDG PET/CT in gallbladder cancer. Nucl Med Mol Imaging. 2012;46:201–6.
Yoo SW, Kim J, Chong A, et al. Metabolic tumor volume measured by F-18 FDG PET/CT can further stratify the prognosis of patients with stage IV non-small cell lung cancer. Nucl Med Mol Imaging. 2012;46:286–93.
Kim J, Yoo SW, Kang SR, et al. Prognostic significance of metabolic tumor volume measured by 18F-FDG PET/CT in operable primary breast cancer. Nucl Med Mol Imaging. 2012;46:278–85.
HS I, Kim SJ, Kim IJ, Kim K. Predictive value of metabolic tumor volume measured by 18F-FDG PET for regional lymph node status in patients with esophageal cancer. Clin Nucl Med. 2012;37:442–6.
Kato H, Miyazaki T, Nakajima M, Takita J, Kimura H, Faried A, et al. The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma. Cancer. 2005;103:148–56.
Mochiki E, Kuwano H, Katoh H, Asao T, Oriuchi N, Endo K. Evaluation of 18F-2-deoxy-2-fluoro-d-glucose positron emission tomography for gastric cancer. World J Surg. 2004;28:247–53.
Zhang C, Chen Y, Xue H, Zheng P, Tong J, Liu J, et al. Diagnostic value of FDG-PET in recurrent colorectal carcinoma: a meta-analysis. Int J Cancer. 2009;124:167–73.
Deleau C, Buecher B, Rousseau C, Kraeber-Bodéré F, Flamant M, des Varannes SB, et al. Clinical impact of fluorodeoxyglucose-positron emission tomography scan/computed tomography in comparison with computed tomography on the detection of colorectal cancer recurrence. Eur J Gastroenterol Hepatol. 2011;23:275–81.
Frankel TL, Gian RK, Jarnagin WR. Preoperative imaging for hepatic resection of colorectal cancer metastasis. J Gastrointest Oncol. 2012;3:11–8.
Bamba Y, Itabashi M, Kameoka S. Value of PET/CT imaging for diagnosing pulmonary metastasis of colorectal cancer. Hepatogastroenterology. 2011;58:1972–4.
Tsunoda Y, Ito M, Fujii H, Kuwano H, Saito N. Preoperative diagnosis of lymph node metastases of colorectal cancer by FDG-PET/CT. Jpn J Clin Oncol. 2008;38:347–53.
Lu YY, Chen JH, Ding HJ, Chien CR, Lin WY, Kao CH. A systematic review and meta-analysis of pretherapeutic lymph node staging of colorectal cancer by 18F-FDG PET or PET/CT. Nucl Med Commun. 2012;33:1127–33.
Skibber JM, Minsky BD, Hoff PM. Principles and practice of oncology. In: DeVita VT, Hellman S, Rosenberg SA, editors. Cancer of the colon., CancerPhiladelphia: Williams & Wilkins; 2001. p. 1216–71.
Carrington BM. Lymph node metastases. In: Husband JES, Reznek RH, editors. Imaging in oncology. London: Taylor & Francis; 2004. p. 999–1022.
Brush J, Boyd K, Chappell F, Crawford F, Dozier M, Fenwick E, et al. The value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation. Health Technol Assess. 2011;15:1–192.
Seol YM, Kwon BR, Song MK, Choi YJ, Shin HJ, Chung JS, et al. Measurement of tumor volume by PET to evaluate prognosis in patients with head and neck cancer treated by chemo-radiation therapy. Acta Oncol. 2010;49:201–8.
Lee HY, Hyun SH, Lee KS, Kim BT, Kim J, Shim YM, et al. Volume-based parameter of 18F-FDG PET/CT in malignant pleural mesothelioma: prediction of therapeutic response and prognostic implications. Ann Surg Oncol. 2010;17:2787–94.
Xie P, Yue JB, Zhao HX, Sun XD, Kong L, Fu Z, et al. Prognostic value of 18F-FDG PET-CT metabolic index for nasopharyngeal carcinoma. J Cancer Res Clin Oncol. 2010;136:883–9.
Chung MK, Jeong HS, Park SG, Jang JY, Son YI, Choi JY, et al. Metabolic tumor volume of [18F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts short-term outcome to radiotherapy with or without chemotherapy in pharyngeal cancer. Clin Cancer Res. 2009;15:5861–8.
Chung HH, Kim JW, Han KH, Eo JS, Kang KW, Park NH, et al. Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer. Gynecol Oncol. 2011;120:270–4.
Acknowledgments
This study is supported by 2 Year Research Grant of Pusan National University.
Conflict of interest
The authors declare no conflict of interest regarding this study.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jo, H.J., Kim, SJ., Kim, I.J. et al. Predictive value of volumetric parameters measured by F-18 FDG PET/CT for lymph node status in patients with surgically resected rectal cancer. Ann Nucl Med 28, 196–202 (2014). https://doi.org/10.1007/s12149-014-0809-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12149-014-0809-x