Skip to main content

Advertisement

SpringerLink
Log in

Recurrence of a functional adrenocortical oncocytoma of borderline malignant potential showing high FDG uptake on 18F-FDG PET/CT

Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Adrenocortical oncocytoma is a very rare tumor, which is not malignant and nonfunctioning in most cases. We report a case of a 53-year-old male with a 9.8 cm sized hyperfunctioning, well-encapsulated adrenal mass, which exhibited by high FDG uptake on a PET/CT scan. The patient had complained of symptoms of Cushing’s syndrome for 4 months. Laparoscopic adrenalectomy was performed and the mass was pathologically confirmed as adrenocortical oncocytoma of uncertain malignant potential. Four years after surgery, the tumor recurred with distant metastases, which was proven by subsequent biopsy. 18F-FDG PET/CT also showed hypermetabolism in the recurred tumor and multiple metastatic lesions. Adrenocortical oncocytoma of borderline malignant potential with high FDG uptake may require long-term follow-up with clinical, hormonal, and imaging evaluations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Erlandson RA, Reuter VE. Oncocytic adrenal cortical adenoma. Ultrastruct Pathol. 1991;15(4–5):539–47.

    Article  CAS  PubMed  Google Scholar 

  2. Chang A, Harawi SJ. Oncocytes, oncocytosis, and oncocytic tumors. Pathol Annu. 1992;27(Pt 1):263–304.

    PubMed  Google Scholar 

  3. Wong DD, Spagnolo DV, Bisceglia M, Havlat M, McCallum D, Platten MA. Oncocytic adrenocortical neoplasms—a clinicopathologic study of 13 new cases emphasizing the importance of their recognition. Hum Pathol. 2011;42(4):489–99.

    Article  CAS  PubMed  Google Scholar 

  4. Kakimoto S, Yushita Y, Sanefuji T, Kondo A, Fujishima N, Kishikawa M, et al. Non-hormonal adrenocortical adenoma with oncocytoma-like appearances. Hinyokika Kiyo. 1986;32(5):757–63.

    CAS  PubMed  Google Scholar 

  5. Ohtake H, Kawamura H, Matsuzaki M, Yokoyama E, Kitajima M, Onizuka S, et al. Oncocytic adrenocortical carcinoma. Ann Diagn Pathol. 2010;14(3):204–8.

    Article  PubMed  Google Scholar 

  6. Bisceglia M, Ludovico O, Di Mattia A, Ben-Dor D, Sandbank J, Pasquinelli G, et al. Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol. 2004;12(3):231–43.

    Article  PubMed  Google Scholar 

  7. Roy AA, Jameson C, Christmas TJ. Aslam Sohaib S. Retroperitoneal oncocytoma: case report and review of the imaging features. Br J Radiol. 2011;84(1004):e161–3.

    Article  CAS  PubMed  Google Scholar 

  8. Shah RK, Oto A, Ozkan OS, Ernst RD, Hernandez JA, Chaudhary HB, et al. Adrenal oncocytoma: US and CT findings. JBR-BTR. 2004;87(4):180–2.

    CAS  PubMed  Google Scholar 

  9. Tirkes T, Gokaslan T, McCrea J, Sandrasegaran K, Hollar MA, Akisik F, et al. Oncocytic neoplasms of the adrenal gland. AJR Am J Roentgenol. 2011;196(3):592–6.

    Article  PubMed  Google Scholar 

  10. Botsios D, Blouhos K, Vasiliadis K, Asimaki A, Tsalis K, Betsis D. Adrenocortical oncocytoma—a rare tumor of undefined malignant potential: report of a case. Surg Today. 2007;37(7):612–7.

    Article  PubMed  Google Scholar 

  11. Tahar GT, Nejib KN, Sadok SS, Rachid LMM. Adrenocortical oncocytoma: a case report and review of literature. J Pediatr Surg. 2008;43(5):E1–3.

    Article  PubMed  Google Scholar 

  12. Okada M, Shimono T, Komeya Y, Ando R, Kagawa Y, Katsube T, et al. Adrenal masses: the value of additional fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in differentiating between benign and malignant lesions. Ann Nucl Med. 2009;23(4):349–54.

    Article  PubMed  Google Scholar 

  13. Kumar R, Xiu Y, Yu JQ, Takalkar A, El-Haddad G, Potenta S, et al. 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med. 2004;45(12):2058–62.

    PubMed  Google Scholar 

  14. Yun M, Kim W, Alnafisi N, Lacorte L, Jang S, Alavi A. 18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. J Nucl Med. 2001;42(12):1795–9.

    CAS  PubMed  Google Scholar 

  15. Maurea S, Mainolfi C, Bazzicalupo L, Panico MR, Imparato C, Alfano B, et al. Imaging of adrenal tumors using FDG PET: comparison of benign and malignant lesions. AJR Am J Roentgenol. 1999;173(1):25–9.

    Article  CAS  PubMed  Google Scholar 

  16. Acar C, Akkas BE, Sen I, Sozen S, Kitapci MT. False positive 18F-FDG PET scan in adrenal oncocytoma. Urol Int. 2008;80(4):444–7.

    Article  CAS  PubMed  Google Scholar 

  17. Minamimoto R, Yamanaka S, Kawamoto M, Endoh M, Nishito R, Yoshida K, et al. High FDG uptake on oncocytoma located in the retroperitoneum mimicking malignancy. Clin Nucl Med. 2007;32(7):582–3.

    Article  PubMed  Google Scholar 

  18. Kim DJ, Chung JJ, Ryu YH, Hong SW, Yu JS, Kim JH. Adrenocortical oncocytoma displaying intense activity on (18)F-FDG-PET: a case report and a literature review. Ann Nucl Med. 2008;22(9):821–4.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by a grant of the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant Number: A111345).

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, 807 Hogukno, Buk-gu, Daegu, 702-210, Republic of Korea

    Seung Hyun Son, Sang-Woo Lee, Bong-Il Song, Shin Young Jeong, Byeong-Cheol Ahn & Jaetae Lee

  2. Department of Radiology, Kyungpook National University School of Medicine and Hospital, Daegu, South Korea

    Yun-Jin Jang

  3. Department of Pathology, Kyungpook National University School of Medicine and Hospital, Daegu, South Korea

    Ji-Young Park

Authors
  1. Seung Hyun Son
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sang-Woo Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bong-Il Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yun-Jin Jang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ji-Young Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shin Young Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Byeong-Cheol Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jaetae Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sang-Woo Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Son, S.H., Lee, SW., Song, BI. et al. Recurrence of a functional adrenocortical oncocytoma of borderline malignant potential showing high FDG uptake on 18F-FDG PET/CT. Ann Nucl Med 28, 69–73 (2014). https://doi.org/10.1007/s12149-013-0764-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12149-013-0764-y

Keywords

Search

Navigation