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Impact of subject head motion on quantitative brain 15O PET and its correction by image-based registration algorithm

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Abstract

Objective

Subject head motion during sequential 15O positron emission tomography (PET) scans can result in artifacts in cerebral blood flow (CBF) and oxygen metabolism maps. However, to our knowledge, there are no systematic studies examining this issue. Herein, we investigated the effect of head motion on quantification of CBF and oxygen metabolism, and proposed an image-based motion correction method dedicated to 15O PET study, correcting for transmission–emission mismatch and inter-scan mismatch of emission scans.

Methods

We analyzed 15O PET data for patients with major arterial steno-occlusive disease (n = 130) to determine the occurrence frequency of head motion during 15O PET examination. Image-based motion correction without and with realignment between transmission and emission scans, termed simple and 2-step method, respectively, was applied to the cases that showed severe inter-scan motion.

Results

Severe inter-scan motion (>3 mm translation or >5° rotation) was observed in 27 of 520 adjacent scan pairs (5.2 %). In these cases, unrealistic values of oxygen extraction fraction (OEF) or cerebrovascular reactivity (CVR) were observed without motion correction. Motion correction eliminated these artifacts. The volume-of-interest (VOI) analysis demonstrated that the motion correction changed the OEF on the middle cerebral artery territory by 17.3 % at maximum. The inter-scan motion also affected CBV, CMRO2 and CBF, which were improved by the motion correction. A difference of VOI values between the simple and 2-step method was also observed.

Conclusions

These data suggest that image-based motion correction is useful for accurate measurement of CBF and oxygen metabolism by 15O PET.

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Acknowledgments

This study was supported by a research grant from the Research Institute for Brain and Blood Vessels Akita. We thank Dr. Kazuhiro Koshino at the National Cerebral and Cardiovascular Center and Dr. Hiroshi Watabe at Osaka University for the technical and scientific advice for this study. We also thank the staff of the Research Institute for Brain and Blood Vessels Akita, particularly Kaoru Sato and Tomomi Omura, for PET acquisition and clinical advice.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Research Institute of Brain and Blood Vessels Akita, 6-10 Senshu-Kubota-machi, Akita, 010-0874, Japan

    Keisuke Matsubara, Masanobu Ibaraki, Kazuhiro Nakamura, Hiroshi Yamaguchi, Atsushi Umetsu, Fumiko Kinoshita & Toshibumi Kinoshita

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  1. Keisuke Matsubara
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  2. Masanobu Ibaraki
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  3. Kazuhiro Nakamura
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  4. Hiroshi Yamaguchi
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  6. Fumiko Kinoshita
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  7. Toshibumi Kinoshita
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Correspondence to Keisuke Matsubara.

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Matsubara, K., Ibaraki, M., Nakamura, K. et al. Impact of subject head motion on quantitative brain 15O PET and its correction by image-based registration algorithm. Ann Nucl Med 27, 335–345 (2013). https://doi.org/10.1007/s12149-013-0690-z

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  • DOI: https://doi.org/10.1007/s12149-013-0690-z

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