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Estimation of 123I-IMP arterial blood activity from dynamic planar imaging of the chest using a graph plot method for the quantification of regional cerebral blood flow

Annals of Nuclear Medicine volume 24, pages 387–393 (2010)Cite this article

Abstract

Purpose

I-123-labeled N-isopropyl-p-iodoamphetamine (123I-IMP) is used for the measurement of regional cerebral blood flow (rCBF). A continuous or single arterial blood sampling (ABS) is necessary to estimate an integral of arterial input function (AIF) for the measurement of rCBF by using a microsphere model analysis. Therefore, a method of measuring rCBF without any blood sampling is desired. The aim of this study was to establish a method to estimate the AIF from the time–activity curve of the lungs after an injection of 123I-IMP, using a regression analysis for the measurement of rCBF without any blood sampling.

Materials and methods

Thirty-seven prospective studies in 10 consecutive patients were enrolled. A chest planar dynamic imaging for 3 min and continuous ABS for 5 min after a bolus injection of 167MBq 123I-IMP were performed in all studies. Data from the chest imaging were analyzed in comparison with ABS data (AIF(5)) in the first 10 studies, and an equation for estimation yielding accurate AIF(5) from the total counts cleared from the lungs, during 5 min after injection of 123I-IMP (TCL(5)), was derived. The validity of the proposed method was evaluated in the subsequent 27 studies.

Results

A good correlation was obtained between the AIF and TCL by regression analysis in the first 10 studies (r = 0.94, P < 0.001). An equation for the estimation of AIF by the regression analysis in the first 10 studies was defined as follows: estimated AIF = 2147 + 4.174 × TCL(5). In the subsequent 27 studies, a good linear correlation was obtained between the measured and the estimated AIF(5) by using the equation (r = 0.79, P < 0.001).

Conclusion

AIF(5) can be accurately estimated from TCL(5). Therefore, estimated AIF(5) can be used for the measurement of rCBF instead of ABS data.

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Affiliations

  1. Department of Diagnostic Radiology, School of Health Sciences, Kumamoto University, 4-24-1 Honjo, Kumamoto, 862-0976, Japan

    Seiji Tomiguchi

  2. Department of Diagnostic Imaging, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

    Kuniyuki Tashiro, Shinya Shiraishi, Morikatsu Yoshida, Koichi Kawanaka & Yasuyuki Yamashita

  3. Clinical Application Technology Department, FUJIFILM RI Pharma Co., Ltd., Tokyo, Japan

    Yoshitake Takahashi & Tsutomu Soma

Authors
  1. Seiji Tomiguchi
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  2. Kuniyuki Tashiro
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  3. Shinya Shiraishi
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  4. Morikatsu Yoshida
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  5. Koichi Kawanaka
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  6. Yoshitake Takahashi
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  7. Tsutomu Soma
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  8. Yasuyuki Yamashita
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Correspondence to Seiji Tomiguchi.

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Tomiguchi, S., Tashiro, K., Shiraishi, S. et al. Estimation of 123I-IMP arterial blood activity from dynamic planar imaging of the chest using a graph plot method for the quantification of regional cerebral blood flow. Ann Nucl Med 24, 387–393 (2010). https://doi.org/10.1007/s12149-010-0370-1

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  • DOI: https://doi.org/10.1007/s12149-010-0370-1

Keywords

  • CBF measurement
  • Arterial input function
  • 123I-IMP
  • Pulmonary dynamic imaging