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Technetium-99m hexamethyl propylene amine oxime-labeled leukocyte scintigraphy at three different times in active ulcerative colitis: comparison with colonoscopy and clinico-biochemical parameters in the assessment of disease extension and severity

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Abstract

Objective

In this study, our objective was to define the usefulness of technetium-99m hexamethyl propylene amine oxime (Tc-99m HMPAO)-labeled leukocyte scintigraphy at three different time points in the assessment of disease extension and severity in patients with active ulcerative colitis (UC).

Methods

Twenty-one consecutive patients (10 women, 11 men; mean age 42.4 ± 12 years) with active UC were prospectively studied. All patients were diagnosed by colonoscopy and histopathology prior to inclusion. Scintigraphy was performed at 1 h, 2 h, and 4 h after Tc-99m HMPAO-labeled leukocyte injection. Clinic-biochemical activity score, total colonoscopic activity score, and total scintigraphic activity score at 1 h, 2 h, and 4 h were calculated for each patient.

Results

Sensitivity, specificity, and accuracy values of Tc-99m HMPAO-labeled leukocyte scintigraphy were calculated as follows, respectively: 1 h imaging 86%, 73%, and 83%; 2 h imaging 89%, 74%, and 86%; 4 h imaging 90%, 58%, and 83% in the detection of active inflammatory segments. Even though no statistically significant difference was found between 1 h, 2 h, and 4 h imaging with respect to the sensitivity, specificity of labeled leukocyte scintigraphy, the largest area under the curve value was found for 2 h imaging.

Conclusions

Tc-99m HMPAO-labeled leukocyte scintigraphy has been found to be correlated well with colonoscopy in the assessment of both the extension and severity of UC. We recommend 2 h scintigraphic imaging because it provides the largest area under the curve value and decreases the number of false-positive results.

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Authors and Affiliations

  1. Department of Nuclear Medicine, School of Medicine, Akdeniz University, Antalya, 07058, Turkey

    Funda Aydın, Fırat Güngör, Adil Boz, Akın Yıldız & Binnur Karayalçın

  2. Internal Medicine Division of Gastroenterology, School of Medicine, Akdeniz University, Antalya, Turkey

    Dinç Dinçer & Serdar Akça

  3. Department of Biostatistics and Medical Informatics, School of Medicine, Akdeniz University, Antalya, Turkey

    Özgür Tosun

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  1. Funda Aydın
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  2. Dinç Dinçer
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Correspondence to Fırat Güngör.

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Aydın, F., Dinçer, D., Güngör, F. et al. Technetium-99m hexamethyl propylene amine oxime-labeled leukocyte scintigraphy at three different times in active ulcerative colitis: comparison with colonoscopy and clinico-biochemical parameters in the assessment of disease extension and severity. Ann Nucl Med 22, 371–377 (2008). https://doi.org/10.1007/s12149-008-0131-6

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  • DOI: https://doi.org/10.1007/s12149-008-0131-6

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