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Development of a tweezers-type coincidence imaging detector

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Abstract

Objective

When employing F-18-fluorodeoxyglucose (FDG)-guided surgery to detect positron accumulation in isolated small organs, sampling these organs from opposite directions is a useful way of determining a tumor’s position, similar to sampling a small organ with tweezers. The coincidence method is suitable for this purpose because only the positrons between two detectors can be detected. For this purpose, we developed a tweezers-type coincidence imaging detector.

Methods

The detector employs two depth-of-interaction (DOI) detectors positioned at the tip of the tweezers and images the positron distribution between them using the coincidence method. The DOI detector consists of a 4 × 3 Gd2SiO5:Ce (GSO) array optically coupled to a one-dimensionally arranged quad-photomultiplier tube. These GSOs were arranged to form a DOI detector using the Anger principle. The useful field of view is 20 mm × 15 mm. With these configurations, we could resolve 4 × 3 GSO arrays on a position histogram.

Results

Because the imaging detectors were positioned at the tip of the tweezers, one could easily sample the target part manually from opposed sides. A real-time image in coincidence between these two DOI detectors could be obtained. The point spread functions were approximately 3-mm full width at half-maximum (FWHM) parallel to the tweezers and 4-mm FWHM perpendicular to them. The sensitivity was ∼1% when the two imaging detectors were 10 mm apart.

Conclusions

With these results, we conclude that the developed tweezers-type imaging detector has a potential to be a new instrument in nuclear medicine

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Authors and Affiliations

  1. Kobe City College of Technology, 8-3 Gakuen-Higashi-machi, Nishi-ku, Kobe, 651-2194, Japan

    Seiichi Yamamoto & Yusuke Sakamoto

  2. Institute of Biomedical Research and Innovation, Kobe, Japan

    Keiichi Matsumoto & Michio Senda

Authors
  1. Seiichi Yamamoto
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  2. Yusuke Sakamoto
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  3. Keiichi Matsumoto
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  4. Michio Senda
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Correspondence to Seiichi Yamamoto.

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Yamamoto, S., Sakamoto, Y., Matsumoto, K. et al. Development of a tweezers-type coincidence imaging detector. Ann Nucl Med 22, 387–393 (2008). https://doi.org/10.1007/s12149-008-0114-7

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  • DOI: https://doi.org/10.1007/s12149-008-0114-7

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