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Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET: a comparison with CT and endoscopic findings

Annals of Nuclear Medicine volume 22, Article number: 261 (2008) Cite this article

Abstract

Objective

We investigated the accumulation of 2-deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) in patients with mucosa-associated lymphoid tissue (MALT) lymphoma patients as compared with computerized tomography (CT) and endoscopic imaging.

Methods

FDG-PET was performed on 13 untreated patients with MALT lymphoma. CT scanning of the affected areas was performed in all the patients to compare with the FDG-PET images. In five patients with gastric MALT lymphoma, comparison was also made with the endoscopic findings.

Results

Of the 13 untreated MALT lymphoma patients, all 8 non-gastric MALT lymphoma patients exhibited abnormal accumulation of FDG. However, in the five gastric MALT lymphoma patients, no abnormal FDG accumulation was observed. Although lesions could be confirmed on CT images from the patients other than those with gastric MALT lymphoma, the mucosal lesions of gastric MALT lymphoma could be observed only by endoscopy.

Conclusions

FDG-PET can be used to detect MALT lymphoma when it forms mass lesions, whereas it is difficult to detect non-massive MALT lymphoma of gastrointestinal origin.

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References

  1. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue: a distinctive type of B-cell lymphoma. Cancer 1983;52:1410–1416.

    PubMed  Article  CAS  Google Scholar 

  2. Cavalli F, Isaacson PG, Gascoyne RD, Zucca E. MALT lymphomas. Hematology (Am Soc Hematol Educ Program) 2001;1:241–258.

    Google Scholar 

  3. Thieblemont C, Berger F, Dumontet C, Moullet I, Bouafia F, Felman P, et al. Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed. Blood 2000;95:802–806.

    PubMed  CAS  Google Scholar 

  4. Stokkel MP, ten Broek FW, van Rijk PP. The role of FDG PET in the clinical management of head and neck cancer. Oral Oncol 1998;34:466–471.

    PubMed  Article  CAS  Google Scholar 

  5. Flanagan FL, Dehdashti F, Siegel BA. PET in breast cancer. Semin Nucl Med 1998;28:290–302.

    PubMed  Article  CAS  Google Scholar 

  6. Bar-Shalom R, Valdivia AY, Blaufox MD. PET imaging in oncology. Semin Nucl Med 2000;30:150–185.

    PubMed  Article  CAS  Google Scholar 

  7. Hustinx R, Benard F, Alavi A. Whole-body FDG-PET imaging in the management of patients with cancer. Semin Nucl Med 2002;32:35–46.

    PubMed  Article  Google Scholar 

  8. Elstrom R, Guan L, Baker G, Nakhoda K, Vergilio JA, Zhuang H, et al. Utility of FDG-PET scanning in lymphoma by WHO classification. Blood 2003;101:3875–3876.

    PubMed  Article  CAS  Google Scholar 

  9. Hoh CK, Glaspy J, Rosen P, Dahlbom M, Lee SJ, Kunkel L, et al. Whole-body FDG-PET imaging for staging of Hodgkin’s disease and lymphoma. J Nucl Med 1997;38:343–348.

    PubMed  CAS  Google Scholar 

  10. Zinzani PL, Magagnoli M, Chierichetti F, Zompatori M, Garraffa G, Bendandi M, et al. The role of positron emission tomography (PET) in the management of lymphoma patients. Ann Oncol 1999;10:1181–1184.

    PubMed  Article  CAS  Google Scholar 

  11. Spaepen K, Stroobants S, Dupont P, Van Steenweghen S, Thomas J, Vandenberghe P, et al. Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxy-glucose ([18F]FDG) after first-line chemotherapy in non-Hodgkin’s lymphoma: is [18F]FDG-PET a valid alternative to conventional diagnostic methods? J Clin Oncol 2001;19: 414–419.

    PubMed  CAS  Google Scholar 

  12. Burton C, Ell P, Linch D. The role of PET imaging in lymphoma. Br J Haematol 2004;126:772–784.

    PubMed  Article  Google Scholar 

  13. Hoffmann M, Kletter K, Becherer A, Jager U, Chott A, Raderer M. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) for staging and follow-up of marginal zone B-cell lymphoma. Oncology 2003;64:336–340.

    PubMed  Article  CAS  Google Scholar 

  14. Beal KP, Yeung HW, Yahalom J. FDG-PET scanning for detection and staging of extranodal marginal zone lymphomas of the MALT type: a report of 42 cases. Ann Oncol 2005; 16:473–480.

    PubMed  Article  CAS  Google Scholar 

  15. Alinari L, Castellucci P, Elstrom R, Ambrosini V, Stefoni V, Nanni C, et al. 18F-FDG PET in mucosa-associated lymphoid tissue (MALT) lymphoma. Leuk Lymphoma 2006;47:2096–2101.

    PubMed  Article  CAS  Google Scholar 

  16. Taal BG, Burgers JM, van Heerde P, Hart AA, Somers R. The clinical spectrum and treatment of primary non-Hodgkin’s lymphoma of the stomach. Ann Oncol 1993;4:839–846.

    PubMed  CAS  Google Scholar 

  17. Schechter NR, Portlock CS, Yahalom J. Treatment of mucosa-associated lymphoid tissue lymphoma of the stomach with radiation alone. J Clin Oncol 1998;16:1916–1921.

    PubMed  CAS  Google Scholar 

  18. Hickeson M, Yun M, Matthies A, Zhuang H, Adam LE, Lacorte L, et al. Use of a corrected standardized uptake value based on the lesion size on CT permits accurate characterization of lung nodules on FDG-PET. Eur J Nucl Med Mol Imaging 2002;29:1639–1647.

    PubMed  Article  Google Scholar 

  19. Boellaard R, Krak NC, Hoekstra OS, Lammertsma AA. Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study. J Nucl Med 2004;45:1519–1527.

    PubMed  Google Scholar 

  20. Spaepen K, Stroobants S, Dupont P, Thomas J, Vandenberghe P, Balzarini J, et al. Can positron emission tomography with [(18)F]-fluorodeoxyglucose after first-line treatment distinguish Hodgkin’s disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity? Br J Haematol 2001;115:272–278.

    PubMed  Article  CAS  Google Scholar 

  21. Hoffmann M, Wohrer S, Becherer A, Chott A, Streubel B, Kletter K, et al. 18F-fluoro-deoxy-glucose positron emission tomography in lymphoma of mucosa-associated lymphoid tissue: histology makes the difference. Ann Oncol 2006;17:1761–1765.

    PubMed  Article  CAS  Google Scholar 

  22. Koga H, Sasaki M, Kuwabara Y, Hiraka K, Nakagawa M, Abe K, et al. An analysis of the physiological FDG uptake pattern in the stomach. Ann Nucl Med 2003;17:733–738.

    PubMed  CAS  Article  Google Scholar 

  23. Neumeister P, Hoefler G, Beham Schmid C, Schmit H, Apfelbeck U, Schaider H, et al. Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa associated lymphoid tissue lymphomas. Gastroenterology 1997;112:1871–1875.

    PubMed  Article  CAS  Google Scholar 

  24. Du M, Peng H, Singh N, Isaacson PG, Pan L. The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma. Blood 1995;86:4587–4593.

    PubMed  CAS  Google Scholar 

  25. Du MQ, Isaccson PG. Gastric MALT lymphoma: from aetiology to treatment. Lancet Oncol 2002;3:97–104.

    PubMed  Article  CAS  Google Scholar 

  26. Waki A, Kato H, Yano R, Sadato N, Yokoyama A, Ishii Y, et al. The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro. Nucl Med Biol 1998;25:593–597.

    PubMed  Article  CAS  Google Scholar 

  27. Torizuka T, Tamaki N, Inokuma T, Magata Y, Sasayama S, Yonekura Y, et al. In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET. J Nucl Med 1995;36:1811–1817.

    PubMed  CAS  Google Scholar 

  28. Koga H, Matsuo Y, Sasaki M, Nakagawa M, Kaneko K, Hayashi K, et al. Differential FDG accumulation associated with GLUT-1 expression in a patient with lymphoma. Ann Nucl Med 2003;17:327–331.

    PubMed  Google Scholar 

  29. Spaepen K, Stroobants S, Dupont P, Vandenberghe P, Thomas J, de Groot T, et al. Early restaging positron emission tomography with (18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma. Ann Oncol 2002;13:1356–1363.

    PubMed  Article  CAS  Google Scholar 

  30. Mikhaeel NG, Timothy AR, O’Doherty MJ, Hain S, Maisey MN. 18-FDG-PET as a prognostic indicator in the treatment of aggressive non-Hodgkin’s lymphoma-comparison with CT. Leuk Lymphoma 2000;39:543–553.

    PubMed  CAS  Google Scholar 

  31. Mikhaeel NG, Hutchings M, Fields PA, O’Doherty MJ, Timothy AR. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. Ann Oncol 2005;16:1514–1523.

    PubMed  Article  CAS  Google Scholar 

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Affiliations

  1. Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Keisuke Enomoto, Kenichiro Hamada & Jun Hatazawa

  2. Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Keisuke Enomoto, Hidenori Inohara & Takeshi Kubo

  3. Department of Clinical Oncology and Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Ichiro Higuchi

  4. Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Yasuhiko Tomita

Authors
  1. Keisuke Enomoto
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  2. Kenichiro Hamada
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  3. Hidenori Inohara
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  4. Ichiro Higuchi
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  5. Yasuhiko Tomita
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  6. Takeshi Kubo
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  7. Jun Hatazawa
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Correspondence to Keisuke Enomoto.

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Enomoto, K., Hamada, K., Inohara, H. et al. Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET: a comparison with CT and endoscopic findings. Ann Nucl Med 22, 261 (2008). https://doi.org/10.1007/s12149-007-0125-9

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  • DOI: https://doi.org/10.1007/s12149-007-0125-9

Keywords

  • MALT
  • Lymphoma
  • FDG
  • PET
  • Findings