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Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease

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Abstract

Objective

The aim of this study is to investigate the relationship between regional cerebral blood flow (rCBF) and symptom clusters of depressive mood in pre-dialytic chronic kidney disease (CKD).

Methods

Twenty-seven patients with stage 4–5 CKD were subjected to statistical parametric mapping analysis of brain single-photon emission computed tomography. Correlation analyses between separate symptom clusters of depressive mood and rCBF were done.

Results

The first factor (depressive mood) was negatively correlated with rCBF in the right insula, posterior cingulate gyrus, and left superior temporal gyrus, and positively correlated with rCBF in the left fusiform gyrus. The second factor (insomnia) was negatively correlated with rCBF in the right middle frontal gyrus, bilateral cingulate gyri, right insula, right putamen, and right inferior parietal lobule, and positively correlated with rCBF in left fusiform gyrus and bilateral cerebellar tonsils. The third factor (anxiety and psychomotor aspects) was negatively correlated with rCBF in the left inferior frontal gyrus, right superior frontal gyrus, right middle temporal gyrus, right superior temporal gyrus, and left superior frontal gyrus, and positively correlated with rCBF in the right ligual gyrus and right parahippocampal gyrus.

Conclusions

In this study, the separate symptom clusters were correlated with specific rCBF patterns similar to those in major depressive disorder patients without CKD. However, some areas with discordant rCBF patterns were also noted when compared with major depressive disorder patients. Further larger scale investigations are needed.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Pusan National University Hospital, 1-10 Ami-dong, Seo-gu, Busan, 602-739, South Korea

    Seong-Jang Kim

  2. Medical Research Institute, Pusan National University Hospital, Busan, South Korea

    Seong-Jang Kim, Sang Heon Song, Ji Hoon Kim & Ihm Soo Kwak

  3. Department of Internal Medicine, Pusan National University Hospital, Busan, South Korea

    Sang Heon Song & Ihm Soo Kwak

  4. Department of Psychiatry, Pusan National University Hospital, Busan, South Korea

    Ji Hoon Kim

Authors
  1. Seong-Jang Kim
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  2. Sang Heon Song
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  3. Ji Hoon Kim
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  4. Ihm Soo Kwak
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Correspondence to Seong-Jang Kim.

Additional information

The first two authors equally contributed to the current study.

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Kim, SJ., Song, S.H., Kim, J.H. et al. Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease. Ann Nucl Med 22, 201–206 (2008). https://doi.org/10.1007/s12149-007-0108-x

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  • DOI: https://doi.org/10.1007/s12149-007-0108-x

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