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Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma

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Abstract

Chondromyxoid fibroma (CMF) is a benign bone tumor. However, it is sometimes difficult to distinguish this tumor from chondrosarcoma. We report a rare case arising from the proximal fibula, presenting multimodality imaging features. An 18-year-old man presented with a 2-year history of gradually increasing pain and swelling in his left knee. Radiograph showed an area of osteolysis with lobulation. Magnetic resonance (MR) imaging demonstrated that almost the whole lesion was enhanced with Gd-DTPA. Scintigraphy examination with 99mTc-biphosphonate showed strong accumulation in the periphery. On Ga-67-citrate scintigraphy, there was a little uptake. Thallium-201 scintigraphy showed strong accumulation of the whole lesion in early and late scans. The tumor was diagnosed as CMF by open biopsy. It is important that CMF is correctly distinguished from other tumors because this may be histologically overdiagnosed as chondrosarcoma. Contrast-enhanced MR imaging and thallium-201 scintigraphy may be useful to distinguish CMF from benign bone tumors or chondrosarcoma.

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References

  1. Unni KK. Chondromyxoid fibroma. In: Unni KK, editor. Dahlin’s bone tumors: general aspects and data on 11 087 cases. 5th ed. Philadelphia: Lippincott-Raven; 1966. p. 59–69.

    Google Scholar 

  2. Campanacci M. Chondromyxoid fibroma. In: Campanacci M, editor. Bone and soft tissue tumors. 2nd ed. Wien: Springer; 1999. p. 265–271.

    Google Scholar 

  3. Ostrowski ML, Spjut HJ, Bridge JA. Chondromyxoid fibroma. In: Fletcher CDM, Unni KK, Mertens F, editors. WHO classification tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 243–245.

    Google Scholar 

  4. Murphy NB, Price CHG. The radiological aspects of chondromyxoid fibroma of bone. Clin Radiol 1971;22:261–269.

    Article  PubMed  CAS  Google Scholar 

  5. Schajowicz F, Gallardo H. Chondromyxoid fibroma (fibromyxoid chondroma) of bone: a clinico-pathological study of thirty-two cases. J Bone Joint Surg Br 1971;53:198–216.

    PubMed  CAS  Google Scholar 

  6. Merine D, Fishman EK, Rosengard A, Tolo V. Chondromyxoid fibroma of the fibula. J Pediatr Orthop 1989;9:468–471.

    PubMed  CAS  Google Scholar 

  7. Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone: a distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Pathol 1948;45:541–551.

    CAS  Google Scholar 

  8. WU CT, Inward CY, O’Laughlin S, Rock MG, Beabout JW, Unni KK. Chondromyxoid fibroma of bone: a clinicopathologic review of 278 cases. Hum Pathol 1998;29:438–446.

    Article  PubMed  CAS  Google Scholar 

  9. Koh JS, Chung JK, Lee SH, Lee JH. Chondrosarcoma of the proximal femur with myxoid degeneration mistaken for chondromyxoid fibroma in a young adult: a case report. Acta Cytol 2001;45:254–258.

    PubMed  CAS  Google Scholar 

  10. Soler R, Rodriguez E, Suarez I, Gayol A. Magnetic resonance imaging of chondromyxoid fibroma of the fibula. Eur J Radiol 1994;18:210–211.

    Article  PubMed  CAS  Google Scholar 

  11. Park SH, Kong KY, Chung HW, Kim CJ, Lee SH, Kang HS. Juxtacortical chondromyxoid fibroma arising in an apophysis. Skeletal Radiol 2000;29:466–469.

    Article  PubMed  CAS  Google Scholar 

  12. Macdonald D, Fornasier V, Holtby R. Chondromyxoid fibroma of the acromium with soft tissue extension. Skeletal Radiol 2000;29:168–170.

    Article  PubMed  CAS  Google Scholar 

  13. Nakazora S, Kusuzaki K, Matsumine A, Seto M, Fukutome K, Uchida A. Case report: chondromyxoid fibroma arising at the clavicular diaphysis. Anticancer Res 2003;23:3517–3522.

    PubMed  Google Scholar 

  14. Aoki J, Sone S, Fujioka F, Terayama K, Ishii K, Karakida O, et al. MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr 1991;15:1011–1016.

    Article  PubMed  CAS  Google Scholar 

  15. De Beuckeleer LH, De Schepper AMA, Ramon F. Magnetic resonance imaging in cartilaginous tumors: is it useful or necessary? Skeletal Radiol 1996;25:137–141.

    Article  PubMed  Google Scholar 

  16. Caluser CI, Abdel-Dayem HM, Macapinlac HA, Scott A, Healey JH, Huvos A, et al. The value of thallium and three-phase bone scans in the evaluation of bone and soft tissue sarcomas. Eur J Nucl Med 1994;21:1198–1205.

    Article  PubMed  CAS  Google Scholar 

  17. Nishiyama Y, Yamamoto Y, Toyama Y, Satoh K, Ohkawa M, Tanabe M. Diagnostic value of Tl-201 and three-phase bone scintigraphy for bone and soft-tissue tumors. Clin Nucl Med 2000;25:200–205.

    Article  PubMed  CAS  Google Scholar 

  18. Arsos G, Venizelos I, Karatzas N, Koukoulidis A, Karakatsanis C. Low-grade chondrosarcoma: a difficult target for radionuclide imaging. Case report and review of the literature. Eur J Radiol 2002;43:66–72.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Hiroaki Murata, Naoyuki Horie, Takaaki Matsui, Takanori Akai, Hideki Ueda, Yasushi Oshima & Toshikazu Kubo

  2. Department of Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Eiichi Konishi

Authors
  1. Hiroaki Murata
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  2. Naoyuki Horie
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  3. Takaaki Matsui
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  4. Takanori Akai
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  5. Hideki Ueda
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  6. Yasushi Oshima
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  7. Eiichi Konishi
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  8. Toshikazu Kubo
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Correspondence to Hiroaki Murata.

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Murata, H., Horie, N., Matsui, T. et al. Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med 22, 221–224 (2008). https://doi.org/10.1007/s12149-007-0102-3

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  • DOI: https://doi.org/10.1007/s12149-007-0102-3

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