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Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

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Abstract

The aim of the study was to compare the diagnostic performances of visual and quantitative analyses of double-phase Tc-99m methoxyisobutylisonitrile (MIBI) scintimammography (SMM) in patients with ultrasonographically indeterminate findings. SMM (early: 10 min; delayed: 3 h) was performed on 78 patients (malignant 66, benign 12). For visual analysis, the five-scoring method was used. For quantitative analysis, ratios of early and delayed lesions to non-lesion (L/Ns) were calculated. When a visual grade of over 3 was used as the cut-off value for the detection of primary breast cancer, the sensitivity and specificity were 86.4% and 100%, respectively. The area under the curve (AUC) was 0.972. The optimal L/N ratios were 1.22 for early and 1.1 for delayed images. When early L/N 1.22 was used as the cut-off point, the sensitivity and specificity of SMM were 92.4% and 91.7%, respectively. The AUC was 0.952. When delayed L/N 1.1 was used as the cut-off value, the sensitivity and specificity were 78.8% and 91.7%, respectively. The AUC was 0.863. Visual interpretation and early L/N were superior to delayed L/N for the detection of breast cancer. This study suggests the possible diagnostic role of visual and quantitative analyses of double-phase SMM for differentiating malignant breast lesions in patients with ultrasonographically indeterminate findings.

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Authors and Affiliations

  1. Department of Nuclear Medicine, College of Medicine, Pusan National University, 1-10, Ami-dong, Seo-gu, Busan, 602-739, South Korea

    Seong-Jang Kim, Young-Tae Bae & Yong-Ki Kim

  2. Department of Surgery, College of Medicine, Pusan National University, Busan, South Korea

    Young-Tae Bae

  3. Medical Research Institute, College of Medicine, Pusan National University, Busan, South Korea

    Seong-Jang Kim, Young-Tae Bae, Jung S. Lee, In-Ju Kim & Yong-Ki Kim

  4. Department of Orthopaedic Surgery, College of Medicine, Pusan National University, Busan, South Korea

    Jung S. Lee

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  1. Seong-Jang Kim
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  2. Young-Tae Bae
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Correspondence to Seong-Jang Kim.

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This work was supported by Pusan National University Research Grant

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Kim, SJ., Bae, YT., Lee, J. et al. Diagnostic performances of double-phase Tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses. Ann Nucl Med 21, 145–150 (2007). https://doi.org/10.1007/s12149-006-0002-y

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  • DOI: https://doi.org/10.1007/s12149-006-0002-y

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