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Oncocytoid Variant of High-Grade Salivary Duct Carcinoma: A Potential Diagnostic Pitfall. A Report on Two Patients

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Salivary duct carcinoma (SDC) is an uncommon and aggressive salivary malignancy. The oncocytoid variant of salivary duct carcinoma (OSDC) has only been reported in the English literature once before. Here we detail two new patients. A 71-year-old female presented with a painless enlarging left parotid mass. Imaging and fine-needle aspiration were nondiagnostic. The second patient, a 79-year-old male, presented with painless swelling in the right cheek. Imaging was nondiagnostic. Both patients underwent surgical resection. Histopathology revealed bland yet infiltrative OSDC in both cases. These tumors were AR+ (androgen receptor) by immunohistochemistry. Potential difficulty exists in distinguishing the oncocytoid variant of SDC, a rare and relatively bland tumor, from oncocytoma, a more commonly encountered entity. AR expression can aid in the correct diagnosis.

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  1. Sekhri R, Ortanca I, Boals C, Agarwal S. Salivary duct carcinoma: a case report of oncocytic variant with possible treatment implications and review of literature. Pathol Res Pract. 2019;215(10):152549.

    Article  CAS  Google Scholar 

  2. Simpson RH. Salivary duct carcinoma: new developments–morphological variants including pure in situ high grade lesions; proposed molecular classification. Head Neck Pathol. 2013;7(Suppl 1):S48-58.

    Article  Google Scholar 

  3. El-Naggar AK, Chan JK, Grandis JR, Takata T, Slootweg PJ. WHO classification of head and neck tumours. 4th ed. Lyon: International Agency for Research on Cancer; 2017.

  4. D’Heygere E, Meulemans J, Vander PV. Salivary duct carcinoma. Curr Opin Otolaryngol Head Neck Surg. 2018;26(2):142–51.

    Article  Google Scholar 

  5. Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T. Salivary duct carcinoma: updates in histology, cytology, molecular biology, and treatment. Cancer Cytopathol. 2020;128(10):693–703.

    Article  CAS  Google Scholar 

  6. Lubin D, Song S, Zafar HM, Baloch Z. The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland. Diagn Cytopathol. 2019;47(6):617–36.

    Article  Google Scholar 

  7. Brandwein MS, Huvos AG. Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 1991;15(6):514–28.

    Article  CAS  Google Scholar 

  8. Bauer WH, Bauer JD. Classification of glandular tumors of salivary glands; study of one-hundred forty-three cases. AMA Arch Pathol. 1953;55(4):328–46.

    CAS  PubMed  Google Scholar 

  9. Sepulveda I, Platin E, Spencer ML, Mucientes P, Frelinghuysen M, Ortega P, et al. Oncocytoma of the parotid gland: a case report and review of the literature. Case Rep Oncol. 2014;7(1):109–16.

    Article  Google Scholar 

  10. Palakshappa SG, Bansal V, Reddy V, Kamarthi N. Oncocytoma of minor salivary gland involving the retromolar region: A rare entity. J Oral Maxillofac Pathol. 2014;18(1):127–30.

    Article  Google Scholar 

  11. Wan Ahmad Kammal WS, Azman M, Salleh AA, Md Pauzi SH, Abd Shukor N. Parotid gland oncocytic carcinoma: a rare entity in head and neck region. Malays J Pathol. 2020;42(2):283–6.

    CAS  PubMed  Google Scholar 

  12. Rammeh S, Romdhane E, Ksentini M, Belhajkacem L, Znaidi N, Riahi I, et al. Accuracy of fine-needle aspiration cytology in the diagnosis of salivary gland masses according to the Milan reporting system and to an in-house system. Diagn Cytopathol. 2021;49(4):528–32.

    Article  Google Scholar 

  13. Jain D, Nayak NC. Oncocytic mucoepidermoid carcinoma of the parotid gland: a case report and review of the literature. Ear Nose Throat J. 2015;94(7):E11–8.

    Article  Google Scholar 

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Conceptualization: AM, SG, RLC, MBW; Research: AM, JEB, SG, MR; writing—original draft preparation: AM, JEB, SG; writing—review and editing: AM, JEB, SG, MR, MLU, RLC, MBW; supervision: MLU, RLC, MBW.

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Correspondence to John E. Beute.

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Matloob, A., Beute, J.E., Gidumal, S. et al. Oncocytoid Variant of High-Grade Salivary Duct Carcinoma: A Potential Diagnostic Pitfall. A Report on Two Patients. Head and Neck Pathol 16, 947–955 (2022).

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