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Histologic and Immunopathologic Variability in Primary Intraoral Angiosarcoma: A Case Report and Review of the Literature

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Abstract

Primary intraoral angiosarcoma is an exceptionally rare malignancy of vascular origin which can be challenging to diagnose due to microscopic and immunohistochemical variability. A histopathologically challenging case of primary intraoral angiosarcoma, occurring in a pediatric patient is presented. A comprehensive review of the literature reveals that primary intraoral angiosarcomas occur with nearly equal frequency in males and females, affect the gingiva and the tongue most commonly and are treated primarily with surgery. As with angiosarcoma in other sites, primary intraoral angiosarcoma behaves aggressively with the majority of patients succumbing to their disease.

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Acknowledgements

The authors would like to thank Dr. Brendan Dickson, Dr. Ilan Weinreb and Dr. Cristina Antonescu for their consultation and the molecular testing of this case.

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Authors and Affiliations

  1. Department of Dentistry, London Health Sciences Centre, London, ON, Canada

    Massimo Di Battista & Christina McCord

  2. Department of Dentistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Mark R. Darling & Christina McCord

  3. Division of Oral Pathology, Department of Pathology and Laboratory Medicine, Western University, 1151 Richmond Street, London, ON, N6A 4C1, Canada

    Mark R. Darling & Christina McCord

  4. Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada

    Mark R. Darling, Bret Wehrli & Christina McCord

  5. Guelph Oral Surgery, Guelph, ON, Canada

    Edgar Scrivener

  6. Great Lakes Oral and Maxillofacial Surgery Centre, Windsor, ON, Canada

    Richard Stapleford

  7. Department of Oral and Maxillofacial Surgery and Dentistry, Windsor Regional Hospital, Windsor, ON, Canada

    Richard Stapleford

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  1. Massimo Di Battista
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  2. Mark R. Darling
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  3. Edgar Scrivener
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Correspondence to Christina McCord.

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Di Battista, M., Darling, M.R., Scrivener, E. et al. Histologic and Immunopathologic Variability in Primary Intraoral Angiosarcoma: A Case Report and Review of the Literature. Head and Neck Pathol 14, 1139–1148 (2020). https://doi.org/10.1007/s12105-020-01134-2

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