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Laryngeal Epstein–Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child


Smooth muscle tumors associated with Epstein–Barr virus infections (EBV–SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for α-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author’s knowledge, this is the first literature-reported case of laryngeal EBV–SMT occurring in an undernourished child.

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This work was supported by São Paulo Research Foundation (FAPESP), Grant Number #2015/25905-1.

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Correspondence to Ciro Dantas Soares.

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The authors declare no potential conflicts of interest related to this case report, to this study’s authorship, and/or to its publication.

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Soares, C.D., Carlos, R., Molina, J.P.D. et al. Laryngeal Epstein–Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child. Head and Neck Pathol 13, 722–726 (2019).

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  • Epstein–Barr virus infections/pathology
  • Smooth muscle tumor/pathology
  • Pediatric tumors