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Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy Radiology–Pathology Correlation

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Abstract

Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a rare, benign type of non-Langerhans cell histiocytosis. The radiological findings are often nonspecific, potentially mimicking malignancies. The diagnosis is ultimately made based on pathology, in which the lymph nodes are characterized by a dilated subcapsular sinus filled with histiocytes that can exhibit emperipolesis. Immunohistochemically, the histiocytes are variably CD68 positive and reliably negative for CD1a. The features of head and neck sinus histiocytosis with massive lymphadenopathy are exemplified in this radiology-pathology correlation sine qua non article.

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References

  1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer. 1972;30:1174–88.

    Article  CAS  Google Scholar 

  2. Shanmugam V, Margolskee E, Kluk M, Giorgadze T, Orazi A. Rosai-Dorfman disease harboring an activating KRAS K117N missense mutation. Head Neck Pathol. 2016;10:394–9.

    Article  Google Scholar 

  3. Cai Y, Shi Z, Bai Y. Review of Rosai-Dorfman disease: new insights into the pathogenesis of this rare disorder. Acta Haematol. 2017;138:14–23.

    Article  CAS  Google Scholar 

  4. Dalia S, Sagatys E, Sokol L, Kubal T. Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control. 2014;21:322–7.

    Article  Google Scholar 

  5. Xu Q, Fu L, Liu C. Multimodality imaging-based evaluation of Rosai-Dorfman disease in the head and neck: a retrospective observational study. Medicine. 2017;96:e9372.

    Article  Google Scholar 

  6. Averitt AW, Heym K, Akers L, Castro-Silva F, Ray A. Sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman disease): diagnostic and treatment modalities for this rare entity revisited. J Pediatr Hematol Oncol. 2018;40:e198–202.

    Article  Google Scholar 

  7. Raslan OA, Schellingerhout D, Fuller GN, Ketonen LM. Rosai-Dorfman disease in neuroradiology: imaging findings in a series of 10 patients. AJR Am J Roentgenol. 2011;196:W187–93.

    Article  Google Scholar 

  8. La Barge DV 3rd, Salzman KL, Harnsberger HR, Ginsberg LE, Hamilton BE, Wiggins RH 3rd, Hudgins PA. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): imaging manifestations in the head and neck. AJR Am J Roentgenol. 2008;191:W299–306.

    Article  Google Scholar 

  9. Kroft SH. Rosai-Dorfman disease: familiar yet enigmatic. Semin Diagn Pathol. 2016;33:244–53.

    Article  Google Scholar 

  10. Paulli M, Bergamaschi G, Tonon L, Viglio A, Rosso R, Facchetti F, Geerts ML, Magrini U, Cazzola M. Evidence for a polyclonal nature of the cell infiltrate in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Br J Haematol. 1995;91:415–8.

    Article  CAS  Google Scholar 

  11. Colmenero I, Molho-Pessach V, Torrelo A, Zlotogorski A, Requena L. Emperipolesis: an additional common histopathologic finding in H syndrome and Rosai-Dorfman disease. Am J Dermatopathol. 2012;34:315 – 20.

    Article  Google Scholar 

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Correspondence to Daniel T. Ginat.

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Cracolici, V., Gurbuxani, S. & Ginat, D.T. Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy Radiology–Pathology Correlation. Head and Neck Pathol 13, 656–660 (2019). https://doi.org/10.1007/s12105-018-0941-3

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  • DOI: https://doi.org/10.1007/s12105-018-0941-3

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