Oral Manifestation of Lymphomatoid Granulomatosis

  • Alessandro Antônio Costa Pereira
  • Christian Barros Ferreira
  • João Adolfo Costa Hanemann
  • Livia Maris Ribeiro Paranaiba
  • Patricia Peres Iucif Pereira
  • Carla Isabelly Rodrigues-Fernandes
  • Celeste Sánchez-Romero
  • Oslei Paes de Almeida
  • Felipe Paiva Fonseca
Case Report


Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein–Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. The aim of this report is to present a rare case of LYG affecting an 86-year-old female patient that was diagnosed due to an extensive, ulcerated and painful oral lesion affecting the hard palate. Detailed microscopic evaluation together with a large immunohistochemical study were necessary to achieve the correct diagnosis of LYG.


Lymphoma Oral cavity Lymphomatoid granulomatosis Palate 



This study was supported by grants of the São Paulo State Research Foundation (FAPESP) Process Number 2017/14880-3.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Alessandro Antônio Costa Pereira
    • 1
  • Christian Barros Ferreira
    • 2
  • João Adolfo Costa Hanemann
    • 3
  • Livia Maris Ribeiro Paranaiba
    • 1
  • Patricia Peres Iucif Pereira
    • 4
  • Carla Isabelly Rodrigues-Fernandes
    • 5
  • Celeste Sánchez-Romero
    • 5
  • Oslei Paes de Almeida
    • 5
  • Felipe Paiva Fonseca
    • 5
    • 6
  1. 1.Department of Pathology and Parasitology, Institute of Biomedical SciencesFederal University of AlfenasAlfenasBrazil
  2. 2.Cônego Monte Raso HospitalBaependiBrazil
  3. 3.Department of Clinics and Surgery, School of DentistryFederal University of AlfenasAlfenasBrazil
  4. 4.School of DentistryUniversidade José do Rosário VellanoVarginhaBrazil
  5. 5.Department of Oral Diagnosis, Piracicaba Dental SchoolUniversity of CampinasPiracicabaBrazil
  6. 6.Department of Oral Surgery and Pathology, School of DentistryFederal University of Minas GeraisBelo HorizonteBrazil

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