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Spongiotic Gingival Hyperplasia Synchronously Involving Multiple Sites: Case Report and Review of the Literature

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Abstract

Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion with unique clinicopathologic features that may involve synchronously multiple sites. We present a case with lesions clinically consistent with LJSGH in four jaw quadrants, confirmed by biopsy and review the English literature on multifocal LJSGH cases. A 19 year-old woman presented with circumscribed, erythematous overgrowths on the right and left maxillary and mandibular gingiva. With the provisional diagnosis of multifocal LJSGH, total excision of four maxillary lesions was performed. Clinical, microscopic and immunohistochemical examination with cytokeratin 19 confirmed the diagnosis of LJSGH in multiple sites. The excised lesions showed partial to complete recurrence after 4 months, while spontaneous regression of all but one lesion was observed after 15 months. Twenty cases with synchronous involvement of the gingiva of at least two teeth were previously reported. Their clinical features were comparable to that of solitary LJSGH. Only one case involved all four jaw quadrants. Spontaneous remission has not been documented before. The recognition of multiple lesions with clinicopathologic features diagnostic of LJSGH in the same adult patient argue against the designations “localized” and “juvenile”. Recurrences are common, while remission might occur.

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Authors and Affiliations

  1. Private Practice, Athens, Greece

    Ioannis Siamantas

  2. Department of Oral Medicine and Pathology, Dental School, National and Kapodistrian University of Athens, 2 Thivon Street, 11527, Athens, Greece

    Eleni-Marina Kalogirou, Konstantinos I. Tosios & Alexandra Sklavounou

  3. Department of Periodontology, Dental School, National and Kapodistrian University of Athens, 2 Thivon Street, Athens, Greece

    Ioannis Fourmousis

Authors
  1. Ioannis Siamantas
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  2. Eleni-Marina Kalogirou
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  3. Konstantinos I. Tosios
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  4. Ioannis Fourmousis
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  5. Alexandra Sklavounou
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Correspondence to Konstantinos I. Tosios.

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All Authors declares that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Siamantas, I., Kalogirou, EM., Tosios, K.I. et al. Spongiotic Gingival Hyperplasia Synchronously Involving Multiple Sites: Case Report and Review of the Literature. Head and Neck Pathol 12, 517–521 (2018). https://doi.org/10.1007/s12105-018-0903-9

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  • DOI: https://doi.org/10.1007/s12105-018-0903-9

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