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Adenosquamous Carcinoma of the Tongue

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Abstract

A 51-year-old white female presented with a painful ulcer of the left ventrolateral tongue. An incisional biopsy confirmed a diagnosis of adenosquamous carcinoma. The adenosquamous carcinoma is an uncommon malignant tumor with histopathological features of a squamous carcinoma and an adenocarcinoma. A definitive diagnosis requires histopathological examination of a deep biopsy involving the submucosal tissue. This malignant tumor shows aggressive behavior with early invasive growth and a poor prognosis. The histopathological findings and differential diagnosis of a case of adenosquamous carcinoma of the tongue are discussed.

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References

  1. Gerughty RM, Hennigar GR, Brown FM. Adenosquamous carcinoma of the nasal, oral and laryngeal cavities. A clinicopathologic survey of ten cases. Cancer. 1968;22(6):1140–55.

    Article  CAS  PubMed Central  Google Scholar 

  2. Ellis GL, Auclair PL, Gnepp DR, Goode RK. Other malignant epithelial neoplasms. In: Ellis GL, Auclair PL, Gnepp DR, editors Surgical pathology of the salivary glands. Philadelphia: WB Saunders; 1991. pp. 455–59.

    Google Scholar 

  3. Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumors. Pathology and genetics of head and neck tumors. Lyon: IARC Press; 2005.

    Google Scholar 

  4. Keelawat S, Liu CZ, Roehm PC, Barnes L. Adenosquamous carcinoma of the upper aerodigestive tract: a clinicopathologic study of 12 cases and review of the literature. Am J Otolaryngol. 2002;23(3):160–8.

    Article  PubMed Central  Google Scholar 

  5. Schick U, Pusztaszeri M, Betz M, Ghadjar P, Demiroz C, Kaanders JH, Ozsahin M. Adenosquamous carcinoma of the head and neck: report of 20 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(3):313–20.

    Article  Google Scholar 

  6. Lee RJ, Lin T, Lee SA, Lee KK, Christensen RE. Importance of tumor extent in adenosquamous carcinoma of the head and neck: a retrospective cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:114–20.

    Article  Google Scholar 

  7. Siar CH, Ng KH. Adenosquamous carcinoma of the floor of the mouth and lower alveolus: a radiation-induced lesion? Oral Surg Oral Med Oral Pathol. 1987;63(2):216 – 20.

    Article  CAS  Google Scholar 

  8. Abdelsayed RA, Sangueza OP, Newhouse RF, Singh BS. Abdelsayed RA, Sangueza OP, Newhouse RF, Singh BS. Adenosquamous carcinoma: a case report with immunohistochemical evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(2):173–7.

    Article  CAS  Google Scholar 

  9. Izumi K, Nakajima T, Maeda T, Cheng J, Saku T. Adenosquamous carcinoma of the tongue: report of a case with histochemical, immunohistochemical, and ultrastructural study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(2):178 – 84.

    Article  CAS  Google Scholar 

  10. Scully C, Porter SR, Speight PM, Eveson JW, Gale D. Adenosquamous carcinoma of the mouth: a rare variant of squamous cell carcinoma. Int J Oral Maxillofac Surg. 1999;28(2):125–8.

    Article  CAS  Google Scholar 

  11. Sheahan P, Fitzgibbon J, Lee G, O’Leary G. Adenosquamous carcinoma of the tongue in a 22-year-old female: report of a case with immunohistochemistry. Eur Arch Otorhinolaryngol. 2003;260(9):509 – 12.

    Article  Google Scholar 

  12. Kass JI, Lee SC, Abberbock S, Seethala RR, Duvvuri U. Adenosquamous carcinoma of the head and neck: Molecular analysis using CRTC-MAML FISH and survival comparison with paired conventional squamous cell carcinoma. Laryngoscope 2015;125(11):E371–6.

    Article  CAS  Google Scholar 

  13. Sheahan P, Toner M, Timon CV. Clinicopathological features of head and neck adenosquamous carcinoma. ORL J Otorhinolaryngol Relat Spec. 2005;67(1):10–5.

    Article  Google Scholar 

  14. Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A. Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases. Histopathology. 2004;44(6):570–9.

    Article  CAS  Google Scholar 

  15. Carlson DL. Necrotizing sialometaplasia: a practical approach to the diagnosis. Arch Pathol Lab Med. 2009;133(5):692–8.

    Google Scholar 

  16. Fujino K, Ito J, Kanaji M, Shiomi Y, Saiga T. Adenosquamous carcinoma of the larynx. Am J Otolaryngol 1995;16(2):115–8.

    Article  CAS  Google Scholar 

  17. Masand RP, El-Mofty SK, Ma XJ, Luo Y, Flanagan JJ, Lewis JS Jr. Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature. Head Neck Pathol. 2011;5:108–16.

    Article  PubMed Central  Google Scholar 

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Correspondence to Yeshwant B. Rawal.

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This case was presented at the Continued Competency Examination of the 2014 Annual Meeting of the American Academy of Oral and Maxillofacial Pathology.

Research Involving Human and Animal Participants

This article does not contain any studies with human participants or animals performed by any of the authors.

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Rawal, Y.B., Anderson, K.M. Adenosquamous Carcinoma of the Tongue. Head and Neck Pathol 12, 576–579 (2018). https://doi.org/10.1007/s12105-017-0877-z

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  • DOI: https://doi.org/10.1007/s12105-017-0877-z

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