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A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands

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Abstract

Involvement of the parathyroid glands by non-parathyroid neoplasia is an infrequent event. Rare cases of metastases to the parathyroid gland have been reported in parathyroidectomies and autopsies of patients with known solid or hematopoietic malignancies. Here, we present a case of atypical clonal plasma cells incidentally identified within a parathyroid adenoma resected for hyperparathyroidism and hypercalcemia, which served as the sentinel event for a subsequent diagnosis of plasma cell myeloma. To our knowledge, this is the only reported case of a hematopoietic malignancy involving a parathyroid adenoma and the only reported case of malignant hematopoietic cells initially detected in parathyroidectomy.

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Authors and Affiliations

  1. Department of Pathology, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

    Vincent Cracolici, Jason X. Cheng, Sandeep Gurbuxani & Nicole A. Cipriani

  2. Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

    Raymon H. Grogan

  3. Department of Medicine, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA

    Madina Sukhanova

Authors
  1. Vincent Cracolici
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  2. Raymon H. Grogan
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  3. Madina Sukhanova
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  4. Jason X. Cheng
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  5. Sandeep Gurbuxani
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  6. Nicole A. Cipriani
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Correspondence to Vincent Cracolici.

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Dr. Cracolici, Dr. Grogan, Dr. Sukhanova, Dr. Cheng, Dr. Gurbuxani, and Dr. Cipriani declares that they have no conflict of interest.

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This article does not contain any studies with human participants performed by any of the authors.

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Cracolici, V., Grogan, R.H., Sukhanova, M. et al. A Herald of Plasma Cell Myeloma: A Report of Malignant Plasma Cells Identified in Parathyroid Adenoma and a Review of Non-parathyroid Malignancies in Parathyroid Glands. Head and Neck Pathol 12, 286–290 (2018). https://doi.org/10.1007/s12105-017-0861-7

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  • DOI: https://doi.org/10.1007/s12105-017-0861-7

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