Head and Neck Pathology

, Volume 12, Issue 1, pp 145–149 | Cite as

Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis

  • Rose Mara Ortega
  • Andréia Bufalino
  • Luciana Yamamoto Almeida
  • Claudia Maria Navarro
  • Daphine Caxias Travassos
  • Túlio Morandin Ferrisse
  • Roman Carlos
  • Jorge Esquiche León
Case Report


Multiple salivary gland tumors (MSGTs) are most common in the major than minor salivary glands. The most MSGTs are synchronous, either benign or malignant. A 61-year-old woman was referred presenting nine submucosal nodules, firm to fluctuant, being five nodules on the right side and four nodules on the left side of the upper lip. An incisional biopsy was performed. Hematoxylin and eosin staining was performed in 5-µm sections for histopathologic analysis. Immunohistochemical reactions were carried out in 3-µm sections in accordance with manufacturer’s instructions. The histopathological analysis showed focal area containing low-grade polymorphous adenocarcinoma (PAC) and multiple canalicular adenomas (CAs). Immunohistochemical analysis for each lesion was carefully investigated. Here, we present an unusual case of synchronous PAC and multiple CAs of the minor salivary glands, affecting the upper lip, which appears to be the first case showing PAC and CA.


Minor salivary glands Upper lip Canalicular adenoma Polymorphous adenocarcinoma Multiple salivary glands tumors 



The authors thank the Laboratory of Applied Immunology of the Federal University of São Carlos—UFSCAR, Brazil, for technical support with digital whole slides (FAPESP 14/50256-4 and 11/52090-8). Financial support came from State of São Paulo Research Foundation Grants 2016/11419-0 (Jorge Esquiche León).

Compliance with Ethical Standards

Conflict of interest

There are no conflict of interest or disclosures related to this work.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Rose Mara Ortega
    • 1
    • 4
  • Andréia Bufalino
    • 1
  • Luciana Yamamoto Almeida
    • 1
  • Claudia Maria Navarro
    • 1
  • Daphine Caxias Travassos
    • 1
  • Túlio Morandin Ferrisse
    • 1
  • Roman Carlos
    • 2
  • Jorge Esquiche León
    • 3
  1. 1.Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental SchoolUniversidade Estadual Paulista (UNESP)AraraquaraBrazil
  2. 2.Director of Centro Clínico de Cabeza y CuelloGuatemala CityGuatemala
  3. 3.Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, School of Dentistry of Ribeirao PretoUniversity of Sao Paulo (USP)Ribeirao PretoBrazil
  4. 4.Oral MedicineFederal University of Juiz de Fora - UFJF/GVGovernador ValadaresBrazil

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