Head and Neck Pathology

, Volume 12, Issue 1, pp 127–130 | Cite as

Laryngotracheal Involvement in Systemic Light Chain Amyloidosis

  • Daniel T. GinatEmail author
  • Jefree Schulte
  • Louis Portugal
  • Nicole A. Cipriani
Sine qua non Radiology-Pathology


Laryngotracheal amyloid deposition is an uncommon manifestation of systemic light chain amyloidosis. Diagnostic imaging, such as CT, is useful for suggesting the possibility of amyloidosis and delineating the extent of the lesions for surgical management; however, the diagnosis is confirmed with the histologic finding of amorphous eosinophilic material which stains positively for Congo red and may show apple green birefringence on polarization. These features are exemplified in this sine qua non radiology-pathology correlation article.


Amyloidosis Amyloidoma Larynx Trachea Radiology Pathology 



We are grateful for support received from the University of Chicago Office of Faculty Affairs through the Faculty Initiatives Fund for our Head and Neck Radiology-Pathology Trainee Conference, during which this case was presented.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Daniel T. Ginat
    • 1
    Email author
  • Jefree Schulte
    • 2
  • Louis Portugal
    • 3
  • Nicole A. Cipriani
    • 2
  1. 1.Department of RadiologyUniversity of ChicagoChicagoUSA
  2. 2.Department of PathologyUniversity of ChicagoChicagoUSA
  3. 3.Department of Surgery, Section of OtolaryngologyUniversity of ChicagoChicagoUSA

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