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Head and Neck Pathology

, Volume 12, Issue 1, pp 75–81 | Cite as

Multiple Desmoplastic Cellular Neurothekeomas in Child: Report of the First Oral Case and Review of the Literature

  • Tatiana Fernandes Araújo Almeida
  • Flaviana Dornela Verli
  • Cássio Roberto Rocha dos Santos
  • Saulo Gabriel Moreira Falci
  • Luciana Yamamoto Almeida
  • Lana Kei Yamamoto Almeida
  • Ana Terezinha Marques Mesquita
  • Jorge Esquiche León
Original Paper

Abstract

Cellular neurothekeomas (CNs) are distinctive benign tumors of uncertain histogenesis, with predilection for the skin of the head and neck region. We describe the first case of multiple desmoplastic CNs (DCNs) affecting the oral cavity in a 9-year-old girl. Histopathologic evaluation showed a proliferation of spindle and epithelioid cells, forming nests and bundles, supported by exuberant fibrous stroma, as well as scattered multinucleated floret-like giant cells. The tumor cells were immunopositive for vimentin, CD63, CD56, whereas AE1/AE3, S100, CD34, α-SMA, GFAP, EMA, CD57 and NSE were negative. Ki-67 was <2%. Multiple DCNs should be considered in the differential diagnosis of oral nodular lesions.

Keywords

Oral cavity Cellular neurothekeoma Desmoplastic cellular neurothekeoma Immunohistochemistry Child 

Notes

Acknowledgements

The authors would like to thank the parents and child who agreed to participate in this study.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Tatiana Fernandes Araújo Almeida
    • 1
  • Flaviana Dornela Verli
    • 2
  • Cássio Roberto Rocha dos Santos
    • 1
  • Saulo Gabriel Moreira Falci
    • 1
  • Luciana Yamamoto Almeida
    • 3
  • Lana Kei Yamamoto Almeida
    • 4
  • Ana Terezinha Marques Mesquita
    • 1
  • Jorge Esquiche León
    • 5
  1. 1.Department of Dentistry, Stomatology ClinicalFederal University of Vales do Jequitinhonha e Mucuri (UFVJM) DiamantinaBrazil
  2. 2.Laboratory of Pathology, Department of Basic SciencesFederal University of Vales do Jequitinhonha e Mucuri (UFVJM)DiamantinaBrazil
  3. 3.Hematology Division, Department of Clinical Medicine, Medical School of Ribeirão PretoUniversity of São Paulo (FMRP/USP)Ribeirão PretoBrazil
  4. 4.Department of Pediatric Dentistry, Araraquara Dental SchoolUniversidade Estadual Paulista-UNESPAraraquaraBrazil
  5. 5.Oral Pathology, Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirão PretoUniversity of São Paulo (FORP/USP)Ribeirão PretoBrazil

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