Head and Neck Pathology

, Volume 12, Issue 1, pp 52–61 | Cite as

Nasopharyngeal Angiofibroma: A Clinical, Histopathological and Immunohistochemical Study of 42 Cases with Emphasis on Stromal Features

  • Celeste Sánchez-Romero
  • Roman Carlos
  • Juan Pablo Díaz Molina
  • Lester D. R. Thompson
  • Oslei Paes de Almeida
  • Alicia Rumayor Piña
Original Paper


Nasopharyngeal angiofibroma is a benign but aggressive tumor of unknown etiology, typically occurring in adolescent males. It is described as a rare neoplasm; however, the prevalence seems to have geographic differences. All cases referred to our head and neck clinical and pathology service were reviewed. Most of the patients presented at an advanced stage. The clinical and radiographic features are presented and discussed. Histologically, the tumor shows a highly vascular fibrous proliferation with characteristic plump, angulated and stellate cells, categorized as fibroblasts. Immunohistochemistry was performed on 42 cases to further elucidate the nature of these cells. The stromal cells expressed vimentin and factor XIIIa, the latter expressed most commonly in the giant stellate cells. Inflammation was almost exclusively present in peripheral subepithelial areas. Mast cells were abundant, even in the absence of other inflammatory cells. Lymphatics were observed principally in peripheral regions. Proliferating cells (Ki-67 reactive) were restricted to endothelial cells.


Nasopharyngeal angiofibroma Sinonasal tumor Vascular tumor Immunohistochemistry Imagenology Adolescent Males 



This study was not funded.

Compliance with Ethical Standards

Conflict of interest

All authors declare they have no conflicts of interest.

Ethical Approval

All reviews performed in this study with human participants were done in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. As a retrospective review, informed consent was not required.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental SchoolUniversity of Campinas/UNICAMPPiracicabaBrazil
  2. 2.Centro Clínico de Cabeza y Cuello/Hospital Herrera LlerandiGuatemalaGuatemala
  3. 3.Unidad Nacional de Oncología Pediátrica (UNOP)/Centro Clínico de Cabeza y CuelloGuatemalaGuatemala
  4. 4.Southern California Permanente Medical Group, Department of PathologyWoodland Hills Medical CenterWoodland HillsUSA

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