References
Paksoy M, Eken M, Ayduran E, Altin G. Two cases of granular cell tumors of the head and neck at different sites. Ear Nose Throat J. 2014;93:E15–7.
Thompson LD. Laryngeal granular cell tumor. Ear Nose Throat J. 2009;88:824–5.
Rosai J. Rosai and Ackerman’s surgical pathology. 10th ed. Philadelphia: Elsevier; 2011.
Schittenhelm J, Thiericke J, Nagel C, Meyermann R, Beschorner R. WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy. Cancer Biomark. 2010;7:73–7.
Guo J, Friedman JL, Ma Y. Granular cell tumor of the testicular tunica albuginea: a case report. Appl Immunohistochem Mol Morphol. 2014;22:395–9.
Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, Chun B. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol. 1980;13:301–16.
Niksic M, Slight J, Sanford JR, Caceres JF, Hastie ND. The Wilms’ tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet. 2004;13:463–71.
Hartkamp J, Roberts SG. The role of the Wilms’ tumour-suppressor protein WT1 in apoptosis. Biochem Soc Trans. 2008;36:629–31.
Scharnhorst V, van der Eb AJ, Jochemsen AG. WT1 proteins: functions in growth and differentiation. Gene. 2001;273:141–61.
Mayo MW, Wang CY, Drouin SS, Madrid LV, Marshall AF, Reed JC, Weissman BE, Baldwin AS. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J. 1999;18:3990–4003.
Chrysomali E, Nikitakis NG, Tosios K, Sauk JJ, Papanicolaou SI. Immunohistochemical evaluation of cell proliferation antigen Ki-67 and apoptosis-related proteins Bcl-2 and caspase-3 in oral granular cell tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:566–72.
Lassaletta L, Alonso S, Ballestín C, Martínez-Tello FJ, Alvarez-Vicent JJ. Immunoreactivity in granular cell tumours of the larynx. Auris Nasus Larynx. 1999;26:305–10.
Acknowledgments
The author thanks Dr. E. Chrysomali, Dr. E. Dragoescu, Dr. Y. Ma, Dr. R. Beschorner and Pr J. Schittenhelm. We acknowledge Dr. E. Mazoyer, Dr. F. Lize, Dr. S. Benzakin and Pr. J.M. Ouayoun involved in the management of the patient. We also thank I. Alexandre, M.C. Portenier, F. Bouchard, I. Pluchart, L. Jovanov, V. Guzal, N. Delva, N. Akdim, V. Ipotesi, C. Alfonso, J. Raleche, S. El-Sayeh, L. Delagarde and the NCA/Avicenne, BIUM and CMDP/APHP teams.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Handra-Luca, A. WT1 Expression in Adult Granular Cell Tumor of the Vocal Cord and Tongue. Head and Neck Pathol 10, 275–277 (2016). https://doi.org/10.1007/s12105-015-0642-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12105-015-0642-0