Abstract
Nodular fasciitis is a lesion found in the subcutaneous fascia that micoscopically presents as a benign proliferation of fibroblasts and myofibroblasts, which may be mistaken for a sarcoma due to clinically rapid growth. Diagnosis is by histopathology and of the immunohistochemical profile. We describe a case of nodular fasciitis in the oral cavity that demonstrated partial spontaneous regression. The patient was a 32-year-old man with a buccal mucosal mass, which had grown rapidly for 45 days. On microscopic examination, the lesion displayed a well-delineated but not encapsulated proliferation of spindle cells, with a nodular growth pattern. Immunohistochemical analysis showed positivity of the spindle cells for the antibodies against smooth muscle actin and muscle-specific actin (HHF-35). Treatment of such lesions typically involves complete conservative excision, but the lesion may regress eventually in the absence of definitive treatment.
Similar content being viewed by others
References
Jang EJ, Park TI, Nam SC, Park JY. Nodular fasciitis in the submandibular gland. Diagn Cytopathol. 2008;36:805–8.
Lenyoun EH, Wu JK, Ebert B, Lieberman B. Rapidly growing nodular fasciitis in the cheek of an infant: case report of a rare presentation. Eplasty. 2008;8:e30.
Konwaler BE, Keasbey L, Kaplan L. Subcutaneous pseudosarcomatous fibromatosis (fasciitis). Am J Clin Pathol. 1955;25:241–52.
Leventis M, Vardas E, Gkouzioti A, Chrysomali E, Chatzistamou I. Oral nodular fasciitis: Report of a case of the buccal mucosa. J Craniomaxillofac Surg 2010 (epub ahead of print).
Martinez-Blanco M, Bagan JV, Alba JR, Basterra J. Maxillofacial nodular fasciitis: a report of 3 cases. J Oral Maxillofac Surg. 2002;60:1211–4.
Dayan D, Nasrallah V, Vered M. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity: 1. Nodular fasciitis. J Oral Pathol Med. 2005;34:426–35.
Nair P, Barrett AW, Theodossy T. Oral nodular fasciitis: case report. Br J Oral Maxillofac Surg. 2004;42:360–2.
Yanagisawa A, Okada H. Nodular fasciitis with degeneration and regression. J Craniofac Surg. 2008;19:1167–70.
Han W, Hu Q, Yang X, Wang Z, Huang X. Nodular fasciitis in the orofacial region. Int J Oral Maxillofac Surg. 2006;35:924–7.
Sharma AK, Scott G, Westesson PL. MRI sign of nodular fasciitis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:e53–6.
Haddad AJ, Avon SL, Clokie CM, Sandor GK. Nodular fasciitis in the oral cavity. J Can Dent Assoc. 2001;67:664–7.
Werning JT. Nodular fasciitis of the orofacial region. Oral Surg Oral Med Oral Pathol. 1979;48:441–6.
Davies HT, Bradley N, Bowerman JE. Oral nodular fasciitis. Br J Oral Maxillofac Surg. 1989;27:147–51.
Kim SM, Myoung H, Choung PH, Kim MJ, Lee SK, Lee JH. Metastatic leiomyosarcoma in the oral cavity: case report with protein expression profiles. J Craniomaxillofac Surg. 2009;37:454–60.
Montgomery EA, Meis JM. Nodular fasciitis. Its morphologic spectrum and immunohistochemical profile. Am J Surg Pathol. 1991;15(10):942–8.
Eversole LR, Christensen R, Ficarra G, Pierleoni L, Sapp JP. Nodular fasciitis and solitary fibrous tumor of the oral region: tumors of fibroblast heterogeneity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:471–6.
Huter EN, Lee CC, Sherry RM, Udey MC. Spontaneous regression and recurrence in a case of nodular fasciitis. Acta Derm Venereol. 2009;89:438–9.
Bacac M, Migliavacca E, Stehle JC, McKee T, Delorenzi M, Coindre JM, et al. A gene expression signature that distinguishes desmoid tumours from nodular fasciitis. J Pathol. 2006;208:543–53.
Conflict of interest
The authors declare no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
de Carli, M.L., Sá Fernandes, K., dos Santos Pinto, D. et al. Nodular Fasciitis of the Oral Cavity with Partial Spontaneous Regression (Nodular Fasciitis). Head and Neck Pathol 7, 69–72 (2013). https://doi.org/10.1007/s12105-012-0390-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12105-012-0390-3