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Oral Atypical Cellular Blue Nevus: An Infiltrative Melanocytic Proliferation

Abstract

The atypical cellular blue nevus is an extremely rare nevomelanocytic lesion which lacks precise histologic characterization in the current literature. Given the potential for significant architectural and cytologic overlap with melanoma, further study, including molecular analysis, is needed. This is the first description of an atypical cellular blue nevus of the oral cavity.

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References

  1. Allen AC, Spitz S. Malignant melanoma: a clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer. 1953;6(1):1–45.

    Article  PubMed  CAS  Google Scholar 

  2. Rodriguez HA, Ackerman LV. Cellular blue nevus: clinicopathologic study of forty-five cases. Cancer. 1968;21(3):393–405.

    Article  PubMed  CAS  Google Scholar 

  3. Zembowicz A, Mihm MC. Dermal dendritic melanocytic proliferations: an update. Histopathology. 2004;45(5):433–51.

    Article  PubMed  CAS  Google Scholar 

  4. Temple-Camp CR, Saxe N, King H. Benign and malignant cellular blue nevus. A clinicopathological study of 30 cases. Am J Dermatopathol. 1988;10(4):289–96.

    Article  PubMed  CAS  Google Scholar 

  5. Buchner A, Merrell PW, Carpenter WM. Relative frequency of solitary melanocytic lesions of the oral mucosa. J Oral Pathol Med. 2004;33(9):550–7.

    Article  PubMed  CAS  Google Scholar 

  6. Ojha J, Akers JL, Akers JO, et al. Intraoral cellular blue nevus: report of a unique histopathologic entity and review of the literature. Cutis. 2007;80(3):189–92.

    PubMed  Google Scholar 

  7. Miller CS, Craig RM, Mantich NM. Blue-black macule on the maxillary palate. J Am Dent Assoc. 1987;114(4):503–4.

    PubMed  CAS  Google Scholar 

  8. Martin RC, Murali R, Scolyer RA, et al. So-called “malignant blue nevus”: a clinicopathologic study of 23 patients. Cancer. 2009;115(13):2949–55.

    Article  PubMed  Google Scholar 

  9. Mehregan DA, Gibson LE, Mehregan AH. Malignant blue nevus: a report of eight cases. J Dermatol Sci. 1992;4(3):185–92.

    Article  PubMed  CAS  Google Scholar 

  10. Granter SR, McKee PH, Calonje E, et al. Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called ‘malignant blue nevus’. Am J Surg Pathol. 2001;25(3):316–23.

    Article  PubMed  CAS  Google Scholar 

  11. Connelly J, Smith JL Jr. Malignant blue nevus. Cancer. 1991;67(10):2653–7.

    Article  PubMed  CAS  Google Scholar 

  12. Duteille F, Duport G, Larregue M, et al. Malignant blue nevus: three new cases and a review of the literature. Ann Plast Surg. 1998;41(6):674–8.

    Article  PubMed  CAS  Google Scholar 

  13. Ozgur F, Akyurek M, Kayikcioglu A, et al. Metastatic malignant blue nevus: a case report. Ann Plast Surg. 1997;39(4):411–5.

    Article  PubMed  CAS  Google Scholar 

  14. Aloi F, Pich A, Pippione M. Malignant cellular blue nevus: a clinicopathological study of 6 cases. Dermatology. 1996;192(1):36–40.

    Article  PubMed  CAS  Google Scholar 

  15. Mones JM, Ackerman AB. “Atypical” blue nevus, “malignant” blue nevus, and “metastasizing” blue nevus: a critique in historical perspective of three concepts flawed fatally. Am J Dermatopathol. 2004;26(5):407–30.

    Article  PubMed  Google Scholar 

  16. Avidor I, Kessler E. ‘Atypical’ blue nevus–a benign variant of cellular blue nevus. Presentation of three cases. Dermatologica. 1977;154(1):39–44.

    Article  PubMed  CAS  Google Scholar 

  17. Tran TA, Carlson JA, Basaca PC, et al. Cellular blue nevus with atypia (atypical cellular blue nevus): a clinicopathologic study of nine cases. J Cutan Pathol. 1998;25(5):252–8.

    Article  PubMed  CAS  Google Scholar 

  18. Barnhill RL, Argenyi Z, Berwick M, et al. Atypical cellular blue nevi (cellular blue nevi with atypical features): lack of consensus for diagnosis and distinction from cellular blue nevi and malignant melanoma (“malignant blue nevus”). Am J Surg Pathol. 2008;32(1):36–44.

    Article  PubMed  Google Scholar 

  19. Murali R, McCarthy SW, Scolyer RA. Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls. Adv Anat Pathol. 2009;16(6):365–82.

    Article  PubMed  Google Scholar 

  20. Barnhill RL, Cerroni L, Cook M, et al. State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop. Adv Anat Pathol. 2010;17(2):73–90.

    Article  PubMed  Google Scholar 

  21. Cerroni L, Barnhill R, Elder D, et al. Melanocytic tumors of uncertain malignant potential: results of a tutorial held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008. Am J Surg Pathol. 2010;34(3):314–26.

    Article  PubMed  Google Scholar 

  22. Barnhill RL, Gupta K. Unusual variants of malignant melanoma. Clin Dermatol. 2009;27(6):564–87.

    Article  PubMed  Google Scholar 

  23. Elder DE, Murphy GF. Melanocytic tumors of the skin. Atlas of tumor pathology, Third Series, Fascicle 2. Washington DC: AFIP; 1991.

    Google Scholar 

  24. Magro CM, Crowson AN, Desman G, et al. Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions. Arch Dermatol. 2012;148(3):335–44.

    Article  PubMed  Google Scholar 

  25. Gerami P, Jewell SS, Morrison LE, et al. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009;33(8):1146–56.

    Article  PubMed  Google Scholar 

  26. Scolyer RA, Murali R, McCarthy SW, et al. Histologically ambiguous (“borderline”) primary cutaneous melanocytic tumors: approaches to patient management including the roles of molecular testing and sentinel lymph node biopsy. Arch Pathol Lab Med. 2010;134(12):1770–7.

    PubMed  Google Scholar 

  27. Goette KD, Robinson JW. Atypical cellular blue nevus. J Assoc Mil Dermatol. 1980;6(1):6–8.

    Google Scholar 

  28. Ruiter DJ, van Dijk MC, Ferrier CM. Current diagnostic problems in melanoma pathology. Semin Cutan Med Surg. 2003;22(1):33–41.

    Article  PubMed  Google Scholar 

  29. Crowson NA, Magro CM, Mihm MC. The melanocytic proliferations. A comprehensive textbook of pigmented lesions. New York: Wiley-Liss; 2001.

    Google Scholar 

  30. Isaac AK, Lertsburapa T, Pathria Mundi J, et al. Polyploidy in spitz nevi: a not uncommon karyotypic abnormality identifiable by fluorescence in situ hybridization. Am J Dermatopathol. 2010;32(2):144–8.

    Article  PubMed  Google Scholar 

  31. Vergier B, Prochazkova-Carlotti M, de la Fouchardiere A, et al. Fluorescence in situ hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases. Mod Pathol. 2011;24(5):613–23.

    Article  PubMed  CAS  Google Scholar 

  32. Gammon B, Beilfuss B, Guitart J, et al. Fluorescence in situ hybridization for distinguishing cellular blue nevi from blue nevus-like melanoma. J Cutan Pathol. 2011;38(4):335–41.

    PubMed  Google Scholar 

  33. Gerami P, Zembowicz A. Update on fluorescence in situ hybridization in melanoma: state of the art. Arch Pathol Lab Med. 2011;135(7):830–7.

    PubMed  Google Scholar 

  34. Kwittken J, Negri L. Malignant blue nevus. Case report of a Negro woman. Arch Dermatol. 1966;94(1):64–9.

    Article  PubMed  CAS  Google Scholar 

  35. Shallman RW, Hoehn JL, Lawton BR, et al. Malignant cellular blue nevus: unusual case of a rare tumor. Wis Med J. 1988;87(1):16–8.

    PubMed  CAS  Google Scholar 

  36. Spatz A, Zimmermann U, Bachollet B, et al. Malignant blue nevus of the vulva with late ovarian metastasis. Am J Dermatopathol. 1998;20(4):408–12.

    Article  PubMed  CAS  Google Scholar 

  37. Harvell JD, White WL. Persistent and recurrent blue nevi. Am J Dermatopathol. 1999;21(6):506–17.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Brian S. Shumway.

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Shumway, B.S., Rawal, Y.B., Allen, C.M. et al. Oral Atypical Cellular Blue Nevus: An Infiltrative Melanocytic Proliferation. Head and Neck Pathol 7, 171–177 (2013). https://doi.org/10.1007/s12105-012-0386-z

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  • DOI: https://doi.org/10.1007/s12105-012-0386-z

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