Head and Neck Pathology

, Volume 6, Issue 3, pp 364–368 | Cite as

Nasopharyngeal Carcinoma

  • Laura N. Carle
  • Charles C. Ko
  • James T. CastleEmail author
Sine qua non Radiology-Pathology


A 27-year-old Filipino female, who was previously treated for otitis media, presented following a 2-year history of bilateral cervical lymphadenopathy and ear pain. At her most recent visit, she presented with chief complaints of headache, occasional dizziness, diplopia, epistaxis, and numbness of the left side of her face. Abduction of the left eye was impaired, and a visibly large left cervical neck mass was present.

Radiographic Features

A sagittal T1-weighted magnetic resonance (MR) image of the current case demonstrated abnormal marrow signal within the clivus (Fig.  1), which in this case, indicated direct extension of tumor. An axial T1-weighted pre-contrast MR image demonstrated a mass that favored the left pharyngeal space and extended into the adjacent parapharyngeal space (Fig.  2). An axial T1-weighted post-contrast MR image demonstrated contrast enhancement within this mass, and at the level of the pterygopalatine fossa, perineural spread of tumor along the left...


Eustachian Tube Mucosal Malignant Melanoma Conventional Squamous Cell Carcinoma Basaloid Squamous Cell Carcinoma Indistinct Cell Border 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The opinions and assertions expressed herein are those of the authors and are not to be construed as official or representing the views of the Department of the Navy or the Department of Defense. I certify that all individuals who qualify as authors have been listed; each has participated in the conception and design of this work, the writing of the document, and the approval of the submission of this version; that the document represents valid work; that if we used information derived from another source, we obtained all necessary approvals to use it and made appropriate acknowledgements in the document; and that each takes public responsibility for it. We are military service members. This work was prepared as part of our official duties. Title 17 U.S.C. 105 provides that ‘Copyright protection under this title is not available for any work of the United States Government.’ Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person’s official duties.


  1. 1.
    Barnes L, Everson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. p. 85–97.Google Scholar
  2. 2.
    Jeyakumar A, Brickman TM, Jeyakumar A, Doerr T. Review of nasopharyngeal carcinoma. Ear Nose Throat J. 2006; 85(3):168–70, 172–3, 184.Google Scholar
  3. 3.
    Thompson L. Update on nasopharyngeal carcinoma. Head Neck Pathol. 2007;1(1):81–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Goh J, Lim K. Imaging of nasopharyngeal carcinoma. Ann Acad Med Singapore. 2009;38(9):809–16.PubMedGoogle Scholar
  5. 5.
    Caponigro F, Longo F, Ionna F, Perri F. Treatment approaches to nasopharyngeal carcinoma: a review. Anticancer Drugs. 2010;21(5):471–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Wei KR, Yu YL, Yang YY, et al. Epidemiological trends of nasopharyngeal carcinoma in China. Asian Pac J Cancer Prev. 2010;11(1):29–32.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2012

Authors and Affiliations

  • Laura N. Carle
    • 1
  • Charles C. Ko
    • 2
  • James T. Castle
    • 3
    Email author
  1. 1.Department of Oral & Maxillofacial PathologyNaval Postgraduate Dental School, NMMPT&EBethesdaUSA
  2. 2.Department of RadiologyWalter Reed National Military Medical CenterBethesdaUSA
  3. 3.Department of Anatomic PathologyNaval Medical Center PortsmouthPortsmouthUSA

Personalised recommendations