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Localized Tongue Amyloidosis in a Patient with Neurofibromatosis Type II

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Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Background

Localized Amyloidosis (AL) may rarely involve oral mucosa. This is the first known reported case describing the development of tongue AL in a 30-year-old patient with Neurofibromatosis (NF) type-2.

Case

A female patient presented with a painless, well-circumscribed nodule of the tongue. Her medical history included NF type-2 with chromosome-22 abnormal karyotype (mosaicism), multiple intracranial and spinal meningiomas/schwannomas and unilateral blindness/deafness. The biopsy of the excised lesion of the tongue revealed subepithelial accumulation of an amorphous, nodular, fibrillar material positive for Congo red. Blood examination showed increased Thyroxine-T4 due to thyroid multinodular colloid goiter, but excluded any other hematological/immunological disorder or organ dysfunction. No recurrence was observed after a six-month follow-up.

Conclusion

This case highlights the possibility of oral manifestations as the only sign of AL and reveals the unexpected co-existence of AL and NF 2, for the first time.

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Authors and Affiliations

  1. Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

    Dimitrios Andreadis, Athanasios Poulopoulos, Petros Papadopoulos & Apostolos Epivatianos

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  1. Dimitrios Andreadis
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  2. Athanasios Poulopoulos
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  3. Petros Papadopoulos
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  4. Apostolos Epivatianos
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Correspondence to Dimitrios Andreadis.

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Andreadis, D., Poulopoulos, A., Papadopoulos, P. et al. Localized Tongue Amyloidosis in a Patient with Neurofibromatosis Type II. Head and Neck Pathol 5, 302–305 (2011). https://doi.org/10.1007/s12105-011-0251-5

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  • DOI: https://doi.org/10.1007/s12105-011-0251-5

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