What’s New in the AFIP Fascicle on Salivary Gland Tumors: A Few Highlights from the 4th Series Atlas


After a 12 year interval from the previous fascicle, a new fascicle on Tumors of the Salivary Glands in the new fourth series of the AFIP Atlas of Tumor Pathology was published in 2008. The data, presentation, illustrations, tables, and physical characteristics of the newest fascicle have been updated and improved. There have only been a few alterations and additions to the classification of tumors and tumor-like non-neoplastic conditions of salivary gland. Three of the most significant are discussed in this paper. Sialoblastoma has been reclassified as malignant; inflammatory pseudotumor has been reclassified as neoplastic and re-identified as inflammatory myofibroblastic tumor; and sclerosing polycystic adenosis is a new entity among tumor-like conditions.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4


  1. 1.

    Ellis GL, Auclair PL. Tumors of the salivary glands. atlas of tumor pathology, 3rd series, fascicle 17. Washington DC: Armed Forces Institute of Pathology; 1996.

    Google Scholar 

  2. 2.

    Ellis GL, Auclair PL. Tumors of the salivary glands. AFIP atlas of tumor pathology, 4th series, fascicle 9. Silver Spring MD: ARP Press; 2008.

    Google Scholar 

  3. 3.

    Seifert G, Sobin LH. Histological typing of salivary gland tumours. World Health Organization international histological classification of tumours. New York: Springer; 1991.

    Google Scholar 

  4. 4.

    Williams SB, Ellis GL, Warnock GR. Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol. 2006;10:320–6.

    PubMed  Article  Google Scholar 

  5. 5.

    Barnes L, Eveson J, Reichart P, et al. World health organization classification of tumours. pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.

    Google Scholar 

  6. 6.

    Stones DK, Jansen JC, Griessel D. Sialoblastoma and hepatoblastoma in a newborn infant. Pediatr Blood Cancer. 2009;52:883–5.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Marucci DD, Lawson K, Harper J et al. Sialoblastoma arising in ectopic salivary gland tissue. J Plast Reconstr Aesthet Surg. 2008.

  8. 8.

    Scott JX, Krishnan S, Bourne AJ et al. Treatment of metastatic sialoblastoma with chemotherapy and surgery. Pediatr Blood Cancer. 2006.

  9. 9.

    Huang R, Jaffer S. Imprint cytology of metastatic sialoblastoma. a case report. Acta Cytol. 2003;47:1123–6.

    PubMed  Google Scholar 

  10. 10.

    Simpson PR, Rutledge JC, Schaefer SD, et al. Congenital hybrid basal cell adenoma–adenoid cystic carcinoma of the salivary gland. Pediatr Pathol. 1986;6:199–208.

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    Tatlidede S, Karsidag S, Ugurlu K, et al. Sialoblastoma: a congenital epithelial tumor of the salivary gland. J Pediatr Surg. 2006;41:1322–5.

    PubMed  Article  Google Scholar 

  12. 12.

    Som PM, Brandwein M, Silvers AR, et al. Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tumor. AJNR Am J Neuroradiol. 1997;18:847–50.

    PubMed  CAS  Google Scholar 

  13. 13.

    Luna MA. Sialoblastoma and epithelial tumors in children: their morphologic spectrum and distribution by age. Adv Anat Pathol. 1999;6:287–92.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Brandwein M, Al-Naeif NS, Manwani D, et al. Sialoblastoma: clinicopathological/immunohistochemical study. Am J Surg Pathol. 1999;23:342–8.

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Williams SB, Foss RD, Ellis GL. Inflammatory pseudotumors of the major salivary glands. clinicopathologic and immunohistochemical analysis of six cases. Am J Surg Pathol. 1992;16:896–902.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Coffin CM, Fletcher JA. Inflammatory myofibroblastic tumour. In: Fletcher CDM, Unni KK, Mertens F, editors. World Health Organization classification of tumours, pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 91–3.

    Google Scholar 

  17. 17.

    Rahimi S, Mafera B, Vigili MG. Inflammatory pseudotumor of the parotid gland: report of a case with fine needle aspiration cytology. Acta Cytol. 2004;48:574–6.

    PubMed  Google Scholar 

  18. 18.

    Van Weert S, Manni JJ, Driessen A. Inflammatory myofibroblastic tumor of the parotid gland: case report and review of the literature. Acta Otolaryngol. 2005;125:433–7.

    PubMed  Article  Google Scholar 

  19. 19.

    Coffin CM, Humphrey PA, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Semin Diagn Pathol. 1998;15:85–101.

    PubMed  CAS  Google Scholar 

  20. 20.

    Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. Am J Surg Pathol. 2007;31:509–20.

    PubMed  Article  Google Scholar 

  21. 21.

    Hussong JW, Brown M, Perkins SL, et al. Comparison of DNA ploidy, histologic, and immunohistochemical findings with clinical outcome in inflammatory myofibroblastic tumors. Mod Pathol. 1999;12:279–86.

    PubMed  CAS  Google Scholar 

  22. 22.

    Smith BC, Ellis GL, Slater LJ, et al. Sclerosing polycystic adenosis of major salivary glands. a clinicopathologic analysis of nine cases. Am J Surg Pathol. 1996;20:161–70.

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Gnepp DR, Wang LJ, Brandwein-Gensler M, et al. Sclerosing polycystic adenosis of the salivary gland: a report of 16 cases. Am J Surg Pathol. 2006;30:154–64.

    PubMed  Article  Google Scholar 

  24. 24.

    Skalova A, Gnepp DR, Simpson RH, et al. Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol. 2006;30:939–44.

    PubMed  Article  Google Scholar 

  25. 25.

    Gnepp DR. Sclerosing polycystic adenosis of the salivary gland: a lesion that may be associated with dysplasia and carcinoma in situ. Adv Anat Pathol. 2003;10:218–22.

    PubMed  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Gary L. Ellis.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ellis, G.L. What’s New in the AFIP Fascicle on Salivary Gland Tumors: A Few Highlights from the 4th Series Atlas. Head and Neck Pathol 3, 225–230 (2009). https://doi.org/10.1007/s12105-009-0128-z

Download citation


  • Salivary gland
  • Neoplasia
  • Tumors
  • Neoplasms
  • Malignant
  • Benign
  • Statistics
  • Prevalence
  • Incidence
  • Clinical
  • Radiographic
  • Molecular
  • Immunohistochemistry
  • Prognosis
  • Management
  • Differential diagnoses