Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)
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Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expresses at high level in many cancers and has been suggested as a potential therapeutic target. It was reported that the Kringle (KNG) domain of ROR1 extracellular region is involved in ROR1/ROR2 heterooligomerization. Monoantibodies that target KNG domain of ROR1 could induce apoptosis of chronic lymphocytic leukemia cells. Here we present the backbone and side chain assignments of KNG domain of ROR1, which lays a foundation for its further structural and function research.
KeywordsROR1 Kringle NMR
This work was supported by the National Key Research and Development Program of China (No. 2017YFC0906903), the National Natural Science Foundation of China (No. 81401904, 31400642) and Yunnan Provincial Science and Technology Department (No. 2015FB170).
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Conflict of interest
The authors declare no conflict of interest.
- Ida L, Yamaguchi T, Yanagisawa K, Kajino T, Shimada Y, Suzuki M, Takahashi T (2016) Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2–1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma. Cancer Sci 107:155–161. https://doi.org/10.1111/cas.12858 CrossRefGoogle Scholar
- Masiakowski P, Carroll RD (1992) A novel family of cell surface receptors with tyrosine kinase-like domain. J Biol Chem 267:26181–26190Google Scholar
- Uhrmacher S, Schmidt C, Erdfelder F, Poll-Wolbeck SJ, Gehrke I, Hallek M, Kreuzer KA (2011) Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL). Leuk Res 35:1360–1366. https://doi.org/10.1016/j.leukres.2011.04.006 CrossRefGoogle Scholar