1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase
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The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [13C,15N]-labeled protein. These assignments facilitate further studies of HePTP in the presence of inhibitors to target leukemia and provide further insights into the function of protein tyrosine phosphatases.
KeywordsHePTP Protein tyrosine phosphatase Vanadate Inhibition Protein dynamics Leukemia
This work was supported by the American Diabetes Association Pathway to Stop Diabetes Grant 1-14-ACN-31 and a Brazil Initiative Brown University grant to WP and NIH R01GM098482 to RP.
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