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Backbone 1H, 13C, and 15N resonance assignments of guanylyl cyclase activating protein-1, GCAP1

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Abstract

Guanylyl cyclase activating protein 1 (GCAP1), a member of the neuronal calcium sensor subclass of the calmodulin superfamily, confers Ca2+-dependent activation of retinal guanylyl cyclase that regulates the visual light response. GCAP1 is genetically linked to retinal degenerative diseases. We report backbone NMR chemical shift assignments of Ca2+-saturated GCAP1 (BMRB no. 18026).

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Acknowledgments

We thank Jerry Dallas for technical support and help with NMR experiments. Work supported by NIH grants (EY012347) to J.B.A., (EY11522) to A.M.D., and (RR11973) to the UC Davis NMR facility.

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Authors and Affiliations

  1. Department of Chemistry, University of California, Davis, CA, 95616, USA

    Sunghyuk Lim & James B. Ames

  2. Basic Sciences, Pennsylvania College of Optometry, Salus University, Elkins Park, PA, 19027, USA

    Igor V. Peshenko & Alexander M. Dizhoor

Authors
  1. Sunghyuk Lim
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  2. Igor V. Peshenko
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  3. Alexander M. Dizhoor
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  4. James B. Ames
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Correspondence to James B. Ames.

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Lim, S., Peshenko, I.V., Dizhoor, A.M. et al. Backbone 1H, 13C, and 15N resonance assignments of guanylyl cyclase activating protein-1, GCAP1. Biomol NMR Assign 7, 39–42 (2013). https://doi.org/10.1007/s12104-012-9373-2

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  • DOI: https://doi.org/10.1007/s12104-012-9373-2

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